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Chemical Compound Review:

SureCN9681925 5-oxo-4H-pyrazine-2- carboxamide

Synonyms: HMDB01978, AKOS006237904, AC1L4742, 13924-96-4, 5-Hydroxypyrazinamide, ...

Kraemer, H.J. et al., Moriwaki, Y. et al., Yamamoto, T. et al.

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High impact information on Pyrazinecarboxamide, 4,5-dihydro-5-oxo-

These results suggest that aldehyde oxidase may play a role in the oxidation of allopurinol to oxypurinol and that of pyrazinamide to 5-hydroxypyrazinamide with xanthine dehydrogenase which can oxidize both allopurinol and pyrazinamide in vivo [1].
In vitro conversion of pyrazinamide into 5-hydroxypyrazinamide and that of pyrazinoic acid into 5-hydroxypyrazinoic acid by xanthine oxidase from human liver [2].
The main metabolites, pyrazinoic acid, 5-hydroxypyrazinoic acid and 5-hydroxypyrazinamide, were included as well as uric acid and other purine derivatives to allow detailed study of the pharmacokinetics of the drug, especially in patients with impaired kidney function [3].

References

In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Moriwaki, Y., Yamamoto, T., Nasako, Y., Takahashi, S., Suda, M., Hiroishi, K., Hada, T., Higashino, K. Biochem. Pharmacol. (1993) [Pubmed]
In vitro conversion of pyrazinamide into 5-hydroxypyrazinamide and that of pyrazinoic acid into 5-hydroxypyrazinoic acid by xanthine oxidase from human liver. Yamamoto, T., Moriwaki, Y., Takahashi, S., Hada, T., Higashino, K. Biochem. Pharmacol. (1987) [Pubmed]
Quantification of pyrazinamide and its metabolites in plasma by ionic-pair high-performance liquid chromatography. Implications for the separation mechanism. Kraemer, H.J., Feltkamp, U., Breithaupt, H. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]

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