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Chemical Compound Review

Alloprin     3,5,7,8- tetrazabicyclo[4.3.0]nona- 3,5,9...

Synonyms: Apulonga, Atisuril, Bleminol, Caplenal, Capurate, ...
 
 
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Disease relevance of Allural

 

Psychiatry related information on Allural

 

High impact information on Allural

 

Chemical compound and disease context of Allural

 

Biological context of Allural

 

Anatomical context of Allural

 

Associations of Allural with other chemical compounds

 

Gene context of Allural

  • Inhibition of intracellular ROS production by N-acetylcysteine, TEMPO, Me(2)SO, 1,10-phenanthroline, or allopurinol resulted in a decreased 15dPGJ(2)-dependent HO-1 expression in the cells [34].
  • In fact, allopurinol treatment reduced the colonic levels of MIP-2 and KC by 62% and 64%, respectively [35].
  • Whereas the time course of parasitemia in NOS2-/- x p47phox-/- mice was nearly identical to that seen in normal control mice, allopurinol treatment of these double-KO mice also enhanced the magnitude of peak parasitemia [36].
  • Similarly, mRNA transcripts for IL-1 beta and TNF-alpha among pulmonary mononuclear cells from hemorrhaged mice treated with allopurinol, an inhibitor of XO, were also significantly reduced (P < 0.05 and 0.001, respectively), compared with hemorrhaged control mice not treated with allopurinol [37].
  • Inhibition of xanthine oxidase by prior feeding with either an allopurinol-supplemented or a tungsten-enriched diet prevented hemorrhage-induced activation of CREB, but not NF-kappaB [38].
 

Analytical, diagnostic and therapeutic context of Allural

References

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  32. Prolonged cardiac preservation. Evaluation of the University of Wisconsin preservation solution by comparison with the St. Thomas' Hospital cardioplegic solutions in the rat. Ledingham, S.J., Katayama, O., Lachno, D.R., Yacoub, M. Circulation (1990) [Pubmed]
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  34. 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. Alvarez-Maqueda, M., El Bekay, R., Alba, G., Monteseirín, J., Chacón, P., Vega, A., Martín-Nieto, J., Bedoya, F.J., Pintado, E., Sobrino, F. J. Biol. Chem. (2004) [Pubmed]
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  36. Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide. Gillman, B.M., Batchelder, J., Flaherty, P., Weidanz, W.P. Infect. Immun. (2004) [Pubmed]
  37. Xanthine oxidase-derived oxygen radicals increase lung cytokine expression in mice subjected to hemorrhagic shock. Schwartz, M.D., Repine, J.E., Abraham, E. Am. J. Respir. Cell Mol. Biol. (1995) [Pubmed]
  38. Hemorrhage induces rapid in vivo activation of CREB and NF-kappaB in murine intraparenchymal lung mononuclear cells. Shenkar, R., Abraham, E. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  39. Oxygen-derived free radicals promote hepatic injury in the rat. Arthur, M.J., Bentley, I.S., Tanner, A.R., Saunders, P.K., Millward-Sadler, G.H., Wright, R. Gastroenterology (1985) [Pubmed]
  40. Allopurinol hypersensitivity syndrome as a cause of hepatic fibrin-ring granulomas. Vanderstigel, M., Zafrani, E.S., Lejonc, J.L., Schaeffer, A., Portos, J.L. Gastroenterology (1986) [Pubmed]
  41. Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs. Reimer, K.A., Jennings, R.B. Circulation (1985) [Pubmed]
  42. A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Goldman, S.C., Holcenberg, J.S., Finklestein, J.Z., Hutchinson, R., Kreissman, S., Johnson, F.L., Tou, C., Harvey, E., Morris, E., Cairo, M.S. Blood (2001) [Pubmed]
 
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