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Chemical Compound Review

Alloprin     3,5,7,8- tetrazabicyclo[4.3.0]nona- 3,5,9...

Synonyms: Apulonga, Atisuril, Bleminol, Caplenal, Capurate, ...
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Disease relevance of Allural


Psychiatry related information on Allural


High impact information on Allural


Chemical compound and disease context of Allural


Biological context of Allural


Anatomical context of Allural


Associations of Allural with other chemical compounds


Gene context of Allural

  • Inhibition of intracellular ROS production by N-acetylcysteine, TEMPO, Me(2)SO, 1,10-phenanthroline, or allopurinol resulted in a decreased 15dPGJ(2)-dependent HO-1 expression in the cells [34].
  • In fact, allopurinol treatment reduced the colonic levels of MIP-2 and KC by 62% and 64%, respectively [35].
  • Whereas the time course of parasitemia in NOS2-/- x p47phox-/- mice was nearly identical to that seen in normal control mice, allopurinol treatment of these double-KO mice also enhanced the magnitude of peak parasitemia [36].
  • Similarly, mRNA transcripts for IL-1 beta and TNF-alpha among pulmonary mononuclear cells from hemorrhaged mice treated with allopurinol, an inhibitor of XO, were also significantly reduced (P < 0.05 and 0.001, respectively), compared with hemorrhaged control mice not treated with allopurinol [37].
  • Inhibition of xanthine oxidase by prior feeding with either an allopurinol-supplemented or a tungsten-enriched diet prevented hemorrhage-induced activation of CREB, but not NF-kappaB [38].

Analytical, diagnostic and therapeutic context of Allural


  1. Allopurinol in the treatment of American cutaneous leishmaniasis. Herwaldt, B.L., Neva, F.A., Berman, J.D. N. Engl. J. Med. (1992) [Pubmed]
  2. Occurrence of exanthema in relation to aminopenicillin preparations and allopurinol. Hoigné, R., Sonntag, M.R., Zoppi, M., Hess, T., Maibach, R., Fritschy, D. N. Engl. J. Med. (1987) [Pubmed]
  3. Allopurinol in Duchenne's muscular dystrophy. Thomson, W.H., Smith, I. N. Engl. J. Med. (1978) [Pubmed]
  4. The purine path to chemotherapy. Elion, G.B. Science (1989) [Pubmed]
  5. Allopurinol toxicity masquerading as malignancy. Calin, A. JAMA (1978) [Pubmed]
  6. A clinical trial of adjuvant allopurinol therapy for moderately refractory schizophrenia. Brunstein, M.G., Ghisolfi, E.S., Ramos, F.L., Lara, D.R. The Journal of clinical psychiatry. (2005) [Pubmed]
  7. Absence of effect of allopurinol on oxalate excretion by stone patients on random and controlled diets. Urivetzky, M., Braverman, S., Motola, J.A., Smith, A.D. J. Urol. (1990) [Pubmed]
  8. Allopurinol for the treatment of aggressive behaviour in patients with dementia. Lara, D.R., Cruz, M.R., Xavier, F., Souza, D.O., Moriguchi, E.H. International clinical psychopharmacology. (2003) [Pubmed]
  9. Cochlear protection from carbon monoxide exposure by free radical blockers in the guinea pig. Fechter, L.D., Liu, Y., Pearce, T.A. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  10. the allopurinol test in patients with Rett syndrome. Pineda, M., Vilaseca, M.A., Vernet, A., Campistol, J., Mas, A., Fabrega, C. J. Inherit. Metab. Dis. (1993) [Pubmed]
  11. Allopurinol-induced orotidinuria. A test for mutations at the ornithine carbamoyltransferase locus in women. Hauser, E.R., Finkelstein, J.E., Valle, D., Brusilow, S.W. N. Engl. J. Med. (1990) [Pubmed]
  12. The effect of dietary protein on the clearance of allopurinol and oxypurinol. Berlinger, W.G., Park, G.D., Spector, R. N. Engl. J. Med. (1985) [Pubmed]
  13. Allopurinol not effective in muscular dystrophy. Bakouche, P., Chaouat, D., Nick, J. N. Engl. J. Med. (1979) [Pubmed]
  14. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pacher, P., Nivorozhkin, A., Szabó, C. Pharmacol. Rev. (2006) [Pubmed]
  15. Evaluation of bone marrow toxic reaction in patients treated with allopurinol. Stolbach, L., Begg, C., Bennett, J.M., Silverstein, M., Falkson, G., Harris, D.T., Glick, J. JAMA (1982) [Pubmed]
  16. Allopurinol and gouty hyperuricemia. Efficacy of a single daily dose. Rodnan, G.P., Robin, J.A., Tolchin, S.F., Elion, G.B. JAMA (1975) [Pubmed]
  17. Ischemic injury in the cat small intestine: role of superoxide radicals. Parks, D.A., Bulkley, G.B., Granger, D.N., Hamilton, S.R., McCord, J.M. Gastroenterology (1982) [Pubmed]
  18. Role of oxygen-derived free radicals in diet-induced hemorrhagic pancreatitis in mice. Rutledge, P.L., Saluja, A.K., Powers, R.E., Steer, M.L. Gastroenterology (1987) [Pubmed]
  19. Oxypurinol nephrolithiasis in regional enteritis secondary to allopurinol therapy. Stote, R.M., Smith, L.H., Dubb, J.W., Moyer, T.P., Alexander, F., Roth, J.L. Ann. Intern. Med. (1980) [Pubmed]
  20. Limitation of infarct size for 24 hours by combined treatment with allopurinol plus verapamil during acute myocardial infarction in the dog. Kingma, J.G., Denniss, A.R., Hearse, D.J., Downey, J.M., Yellon, D.M. Circulation (1987) [Pubmed]
  21. Rapid conversion to high xanthine oxidase activity in viable Kupffer cells during hypoxia. Wiezorek, J.S., Brown, D.H., Kupperman, D.E., Brass, C.A. J. Clin. Invest. (1994) [Pubmed]
  22. Inhibition of endotoxin-induced bacterial translocation in mice. Deitch, E.A., Ma, L., Ma, W.J., Grisham, M.B., Granger, D.N., Specian, R.D., Berg, R.D. J. Clin. Invest. (1989) [Pubmed]
  23. Allopurinol enhanced adenine nucleotide repletion after myocardial ischemia in the isolated rat heart. Lasley, R.D., Ely, S.W., Berne, R.M., Mentzer, R.M. J. Clin. Invest. (1988) [Pubmed]
  24. Early midzonal oxidative stress preceding cell death in hypoperfused rat liver. Suematsu, M., Suzuki, H., Ishii, H., Kato, S., Yanagisawa, T., Asako, H., Suzuki, M., Tsuchiya, M. Gastroenterology (1992) [Pubmed]
  25. Role of xanthine oxidase in ethanol-induced lipid peroxidation in rats. Kato, S., Kawase, T., Alderman, J., Inatomi, N., Lieber, C.S. Gastroenterology (1990) [Pubmed]
  26. Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains. Patt, A., Harken, A.H., Burton, L.K., Rodell, T.C., Piermattei, D., Schorr, W.J., Parker, N.B., Berger, E.M., Horesh, I.R., Terada, L.S. J. Clin. Invest. (1988) [Pubmed]
  27. Free radicals and pathogenesis during ischemia and reperfusion of the cat small intestine. Nilsson, U.A., Schoenberg, M.H., Aneman, A., Poch, B., Magadum, S., Beger, H.G., Lundgren, O. Gastroenterology (1994) [Pubmed]
  28. Neutrophils generate oxygen free radicals in rat mesenteric microcirculation after abdominal irradiation. Panés, J., Granger, D.N. Gastroenterology (1996) [Pubmed]
  29. Inefficacy of allopurinol as monotherapy for Colombian cutaneous leishmaniasis. A randomized, controlled trial. Velez, I., Agudelo, S., Hendrickx, E., Puerta, J., Grogl, M., Modabber, F., Berman, J. Ann. Intern. Med. (1997) [Pubmed]
  30. Role of reactive oxygen intermediates in interleukin 10 release after cold liver ischemia and reperfusion in mice. Le Moine, O., Louis, H., Stordeur, P., Collet, J.M., Goldman, M., Devière, J. Gastroenterology (1997) [Pubmed]
  31. Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen. Chocair, P., Duley, J., Simmonds, H.A., Cameron, J.S., Ianhez, L., Arap, S., Sabbaga, E. Lancet (1993) [Pubmed]
  32. Prolonged cardiac preservation. Evaluation of the University of Wisconsin preservation solution by comparison with the St. Thomas' Hospital cardioplegic solutions in the rat. Ledingham, S.J., Katayama, O., Lachno, D.R., Yacoub, M. Circulation (1990) [Pubmed]
  33. Influence of antioxidants (mannitol and allopurinol) on oxygen free radical generation during and after cardiopulmonary bypass. England, M.D., Cavarocchi, N.C., O'Brien, J.F., Solis, E., Pluth, J.R., Orszulak, T.A., Kaye, M.P., Schaff, H.V. Circulation (1986) [Pubmed]
  34. 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. Alvarez-Maqueda, M., El Bekay, R., Alba, G., Monteseirín, J., Chacón, P., Vega, A., Martín-Nieto, J., Bedoya, F.J., Pintado, E., Sobrino, F. J. Biol. Chem. (2004) [Pubmed]
  35. Oxygen radical-dependent expression of CXC chemokines regulate ischemia/reperfusion-induced leukocyte adhesion in the mouse colon. Riaz, A.A., Schramm, R., Sato, T., Menger, M.D., Jeppsson, B., Thorlacius, H. Free Radic. Biol. Med. (2003) [Pubmed]
  36. Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide. Gillman, B.M., Batchelder, J., Flaherty, P., Weidanz, W.P. Infect. Immun. (2004) [Pubmed]
  37. Xanthine oxidase-derived oxygen radicals increase lung cytokine expression in mice subjected to hemorrhagic shock. Schwartz, M.D., Repine, J.E., Abraham, E. Am. J. Respir. Cell Mol. Biol. (1995) [Pubmed]
  38. Hemorrhage induces rapid in vivo activation of CREB and NF-kappaB in murine intraparenchymal lung mononuclear cells. Shenkar, R., Abraham, E. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  39. Oxygen-derived free radicals promote hepatic injury in the rat. Arthur, M.J., Bentley, I.S., Tanner, A.R., Saunders, P.K., Millward-Sadler, G.H., Wright, R. Gastroenterology (1985) [Pubmed]
  40. Allopurinol hypersensitivity syndrome as a cause of hepatic fibrin-ring granulomas. Vanderstigel, M., Zafrani, E.S., Lejonc, J.L., Schaeffer, A., Portos, J.L. Gastroenterology (1986) [Pubmed]
  41. Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs. Reimer, K.A., Jennings, R.B. Circulation (1985) [Pubmed]
  42. A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Goldman, S.C., Holcenberg, J.S., Finklestein, J.Z., Hutchinson, R., Kreissman, S., Johnson, F.L., Tou, C., Harvey, E., Morris, E., Cairo, M.S. Blood (2001) [Pubmed]
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