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Chemical Compound Review:

CHEMBL397560 sodium N-diethylamino-N-oxido-nitrous amide

Synonyms: CCRIS 7920, CHEMBL1627017, LS-65050, Diethylamine/nitric oxide complex

This record was replaced with 107754.

Gergel, D. et al., Messmer, U.K. et al., Quinson, N. et al., Quinson, N. et al., Baskin, S.I. et al.

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Disease relevance of N-diethylamino-N-oxido-nitrous amide

Cyanide toxicity in mice pretreated with diethylamine nitric oxide complex [1].

High impact information on N-diethylamino-N-oxido-nitrous amide

Moreover, diethylamine/nitric oxide complex superfused at the coeliac plexus level inhibited duodenal motility in the absence of gastric distension [2].
To evaluate the mechanism of inhibition, purified ADH from equine liver was incubated with gaseous NO or NO released from NO donors such as the diethylamine/nitric oxide complex (DEA/NO) and SNAP [3].
A nitric oxide donor (diethylamine/nitric oxide complex) induced an inhibition of the nicotinic synaptic transmission [4].
A 30-min exposure to the rapidly decomposing NO-donor diethylamine-nitric oxide complex (DEA-NO) causes irreversible damage and apoptotic cell death after 6 to 8 h [5].

References

Cyanide toxicity in mice pretreated with diethylamine nitric oxide complex. Baskin, S.I., Nealley, E.W., Lempka, J.C. Human & experimental toxicology. (1996) [Pubmed]
Release of nitric oxide within the coeliac plexus is involved in the organization of a gastroduodenal inhibitory reflex in the rabbit. Quinson, N., Catalin, D., Niel, J.P., Miolan, J.P. J. Physiol. (Lond.) (1999) [Pubmed]
Inhibition of the catalytic activity of alcohol dehydrogenase by nitric oxide is associated with S nitrosylation and the release of zinc. Gergel, D., Cederbaum, A.I. Biochemistry (1996) [Pubmed]
Muscarinic receptor activation is a prerequisite for the endogenous release of nitric oxide modulating nicotinic transmission within the coeliac ganglion in the rabbit. Quinson, N., Miolan, J.P., Niel, J.P. Neuroscience (2000) [Pubmed]
Nitric oxide (NO) in apoptotic versus necrotic RAW 264.7 macrophage cell death: the role of NO-donor exposure, NAD+ content, and p53 accumulation. Messmer, U.K., Brüne, B. Arch. Biochem. Biophys. (1996) [Pubmed]

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