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Chemical Compound Review

D-NONOate     N-diethylamino-N-oxido-nitrous amide

Synonyms: Dea-No, CCRIS 8432, KST-1B9312, LS-76731, AR-1B4615, ...
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High impact information on N-diethylamino-N-oxido-nitrous amide


Biological context of N-diethylamino-N-oxido-nitrous amide


Anatomical context of N-diethylamino-N-oxido-nitrous amide


Associations of N-diethylamino-N-oxido-nitrous amide with other chemical compounds


Gene context of N-diethylamino-N-oxido-nitrous amide

  • DEANO resulted in a 50% reduction in CAT, GPX, and a dose-dependent inhibition of Cu, Zn-SOD [14].
  • In the present study, preincubation of purified rat liver microsomal GST with S-nitrosoglutathione (GSNO) or the nitric oxide (NO) donor, 1,1-diethyl-2-hydroxy-2-nitrosohydrazine (DEA/NO), resulted in a 2-fold increase in enzyme activity [15].
  • In contrast, BCS had no effect on either the rate of NO release, or the anti-platelet action of the non-nitrosothiol compound DEANO [7].
  • Hemisected skulls with adhering dura mater were filled with synthetic interstitial fluid and stimulated with the NO donor diethylamine-NONOate (10(-5)-10(-3) M) or with NO gas (1,000 ppm), which caused concentration-dependent increases in CGRP release up to 166.8% [16].


  1. Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Ahluwalia, A., Foster, P., Scotland, R.S., McLean, P.G., Mathur, A., Perretti, M., Moncada, S., Hobbs, A.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. A major role for prostacyclin in nitric oxide-induced ocular vasorelaxation in the piglet. Hardy, P., Abran, D., Hou, X., Lahaie, I., Peri, K.G., Asselin, P., Varma, D.R., Chemtob, S. Circ. Res. (1998) [Pubmed]
  3. autoregulatory role of endothelium-derived nitric oxide (NO) on Lipopolysaccharide-induced vascular inducible NO synthase expression and function. Vo, P.A., Lad, B., Tomlinson, J.A., Francis, S., Ahluwalia, A. J. Biol. Chem. (2005) [Pubmed]
  4. Differing effects of copper,zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins. Ying, W., Anderson, C.M., Chen, Y., Stein, B.A., Fahlman, C.S., Copin, J.C., Chan, P.H., Swanson, R.A. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  5. Structural and kinetic modifications of aldose reductase by S-nitrosothiols. Srivastava, S., Dixit, B.L., Ramana, K.V., Chandra, A., Chandra, D., Zacarias, A., Petrash, J.M., Bhatnagar, A., Srivastava, S.K. Biochem. J. (2001) [Pubmed]
  6. The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo. Wink, D.A., Laval, J. Carcinogenesis (1994) [Pubmed]
  7. Evidence for a cyclic GMP-independent mechanism in the anti-platelet action of S-nitrosoglutathione. Gordge, M.P., Hothersall, J.S., Noronha-Dutra, A.A. Br. J. Pharmacol. (1998) [Pubmed]
  8. Increase in meningeal blood flow by nitric oxide--interaction with calcitonin gene-related peptide receptor and prostaglandin synthesis inhibition. Strecker, T., Dux, M., Messlinger, K. Cephalalgia : an international journal of headache. (2002) [Pubmed]
  9. Nerve conduction block by nitric oxide that is mediated by the axonal environment. Shrager, P., Custer, A.W., Kazarinova, K., Rasband, M.N., Mattson, D. J. Neurophysiol. (1998) [Pubmed]
  10. The neurovascular mechanism of clitoral erection: nitric oxide and cGMP-stimulated activation of BKCa channels. Gragasin, F.S., Michelakis, E.D., Hogan, A., Moudgil, R., Hashimoto, K., Wu, X., Bonnet, S., Haromy, A., Archer, S.L. FASEB J. (2004) [Pubmed]
  11. Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse macrophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound diethylamine dinitric oxide. Sheffler, L.A., Wink, D.A., Melillo, G., Cox, G.W. J. Leukoc. Biol. (1995) [Pubmed]
  12. Nitric oxide modulates the activity of the hemoproteins prostaglandin I2 synthase and thromboxane A2 synthase. Wade, M.L., Fitzpatrick, F.A. Arch. Biochem. Biophys. (1997) [Pubmed]
  13. Hyperhomocysteinemia increases arterial permeability and stiffness in mice. Mullick, A.E., Zaid, U.B., Athanassious, C.N., Lentz, S.R., Rutledge, J.C., Symons, J.D. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  14. Specificity of antioxidant enzyme inhibition in skeletal muscle to reactive nitrogen species donors. Lawler, J.M., Song, W. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  15. Regulation of microsomal and cytosolic glutathione S-transferase activities by S-nitrosylation. Ji, Y., Toader, V., Bennett, B.M. Biochem. Pharmacol. (2002) [Pubmed]
  16. Nitric oxide releases calcitonin-gene-related peptide from rat dura mater encephali promoting increases in meningeal blood flow. Strecker, T., Dux, M., Messlinger, K. J. Vasc. Res. (2002) [Pubmed]
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