High impact information on phenylphosphonic acid

• The present study was designed to assess the utility of phenylphosphonic acid (PPA) as a 31P-NMR extracellular marker in perfused smooth muscle [1].
• Synthesis of novel mesoporous hybrid tin oxophosphate is reported from phenylphosphonic acid as the only precursor of phosphorus in the presence of anionic surfactant (SDS), which possesses a wormhole mesoporous structure and is stable even after calcination at 550 degrees C [2].
• Resolved stereoisomers of ethyl phenylphosphonic acid esters produce two forms of inhibited NTE; in vitro one form ages rapidly and the other only negligibly [3].
• Phenylphosphonic acid (PhPA, 2.5 mM) inhibited Pi transport by 37% at myoplasmic pCa 6.5 and also had a small, direct inhibitory effect on the sarcoplasmic reticulum Ca2+ pump (16%) [4].
• The parent benzenephosphonic acid [Weakley (1976). Acta Cryst. B32, 2889-2890] does not adopt an analogous structure, but its arsenic analogue [Shimada (1960). Bull. Chem. Soc. Jpn, 33, 301-304] does and can be regarded as isostructural [5].

Biological context of phenylphosphonic acid

• As hydrolysis products of the parent compound, phenylphosphonic acid, O-ethyl hydrogen phenylphosphonate, O-ethyl hydrogen phenylphosphonothioate and benzyl alcohol were detected [6].

Anatomical context of phenylphosphonic acid

• Phenylphosphonic acid also inhibits Pi transport, distinguishing the Pi transporter of SR from the Na+/Pi transporter of brush-border membranes [7].

Associations of phenylphosphonic acid with other chemical compounds

• The influence of chirality on the delayed neuropathic potential of some organophosphorus esters: neuropathic and prophylactic effects of stereoisomeric esters of ethyl phenylphosphonic acid (EPN oxon and EPN) correlate with quantities of aged and unaged neuropathy target esterase in vivo [3].

References