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Chemical Compound Review

PubChem21303     phenylphosphonic acid

Synonyms: NSC-145, SureCN34998, NSC145, CHEMBL179801, ACMC-1C27E, ...
 
 
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High impact information on phenylphosphonic acid

  • The present study was designed to assess the utility of phenylphosphonic acid (PPA) as a 31P-NMR extracellular marker in perfused smooth muscle [1].
  • Synthesis of novel mesoporous hybrid tin oxophosphate is reported from phenylphosphonic acid as the only precursor of phosphorus in the presence of anionic surfactant (SDS), which possesses a wormhole mesoporous structure and is stable even after calcination at 550 degrees C [2].
  • Resolved stereoisomers of ethyl phenylphosphonic acid esters produce two forms of inhibited NTE; in vitro one form ages rapidly and the other only negligibly [3].
  • Phenylphosphonic acid (PhPA, 2.5 mM) inhibited Pi transport by 37% at myoplasmic pCa 6.5 and also had a small, direct inhibitory effect on the sarcoplasmic reticulum Ca2+ pump (16%) [4].
  • The parent benzenephosphonic acid [Weakley (1976). Acta Cryst. B32, 2889-2890] does not adopt an analogous structure, but its arsenic analogue [Shimada (1960). Bull. Chem. Soc. Jpn, 33, 301-304] does and can be regarded as isostructural [5].
 

Biological context of phenylphosphonic acid

 

Anatomical context of phenylphosphonic acid

 

Associations of phenylphosphonic acid with other chemical compounds

  • The influence of chirality on the delayed neuropathic potential of some organophosphorus esters: neuropathic and prophylactic effects of stereoisomeric esters of ethyl phenylphosphonic acid (EPN oxon and EPN) correlate with quantities of aged and unaged neuropathy target esterase in vivo [3].

References

  1. Phenylphosphonate: a 31P-NMR indicator of extracellular pH and volume in the isolated perfused rabbit bladder. Fisher, M.J., Dillon, P.F. Circ. Res. (1987) [Pubmed]
  2. Synthesis of organic-inorganic hybrid mesoporous tin oxophosphate in the presence of anionic surfactant. Mal, N.K., Fujiwara, M., Matsukata, M. Chem. Commun. (Camb.) (2005) [Pubmed]
  3. The influence of chirality on the delayed neuropathic potential of some organophosphorus esters: neuropathic and prophylactic effects of stereoisomeric esters of ethyl phenylphosphonic acid (EPN oxon and EPN) correlate with quantities of aged and unaged neuropathy target esterase in vivo. Johnson, M.K., Read, D.J. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  4. Phosphate transport into the sarcoplasmic reticulum of skinned fibres from rat skeletal muscle. Fryer, M.W., West, J.M., Stephenson, D.G. J. Muscle Res. Cell. Motil. (1997) [Pubmed]
  5. 4-Methoxyphenylphosphonic acid: reactivity of Lawesson's reagent. Aragoni, M.C., Arca, M., Blake, A.J., Lippolis, V., Schröder, M., Wilson, C. Acta crystallographica. Section C, Crystal structure communications. (2002) [Pubmed]
  6. Chemical transformation of S-benzyl O-ethyl phenylphosphonothiolate (Inezin) by ultraviolet light. Murai, T., Tomizawa, C. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1976) [Pubmed]
  7. Covalent and non-covalent inhibitors of the phosphate transporter of sarcoplasmic reticulum. Stefanova, H.I., East, J.M., Lee, A.G. Biochim. Biophys. Acta (1991) [Pubmed]
 
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