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Chemical Compound Review:

Ammediol 2-amino-2-methyl-propane-1,3- diol

Synonyms: Gentimon, Aminoglycol, AMPD, CHEBI:991, NSC-6364, ...

Geisthardt, D. et al., Nebot, C. et al., Stinson, R.A., Hirokawa, T. et al.

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High impact information on Gentimon

Hydrophilic liver ALP retained > 90% of its activity after 24 h at 30 degrees C in both 1.0 and 0.3 mol/L Tris and 2-amino-2-methyl-1,3-propanediol and in 0.3 mol/L MEG [1].
The optimized assay of SOD activity is performed at pH 8.8, 37 degrees C, in 50 mM air-saturated 2-amino-2-methyl-1,3- propanediol buffer containing 3 mM boric acid and 0.1 mM diethylenetriaminepentaacetic acid [2].
The leading electrolyte used was 10 mM HCl and the pH buffers were imidazole, tris(hydroxymethylamino)methane, 2-amino-2-methyl-1,3-propanediol and ethanolamine [3].
However, a few primary amines (tris(hydroxymethyl)aminomethane, 2-amino-2-methyl-1,3-propanediol) and secondary amines 3-([2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino)-1-propanesulfonic acid, 3-(dimethyl(hydroxymethyl)methylamino)-2-hydroxypropanesulfonic acid) showed negligible shifts of pH [4].

References

Kinetic parameters for the cleaved substrate, and enzyme and substrate stability, vary with the phosphoacceptor in alkaline phosphatase catalysis. Stinson, R.A. Clin. Chem. (1993) [Pubmed]
Spectrophotometric assay of superoxide dismutase activity based on the activated autoxidation of a tetracyclic catechol. Nebot, C., Moutet, M., Huet, P., Xu, J.Z., Yadan, J.C., Chaudiere, J. Anal. Biochem. (1993) [Pubmed]
Simulated quantitative and qualitative isotachophoretic indices of 73 amino acids and peptides in the pH range 6.4-10. Hirokawa, T., Kiso, Y., Gas, B., Zusková, I., Vacík, J. J. Chromatogr. (1993) [Pubmed]
Polyacrylamide gel electrophoresis: reaction of acrylamide at alkaline pH with buffer components and proteins. Geisthardt, D., Kruppa, J. Anal. Biochem. (1987) [Pubmed]

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