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Chemical Compound Review

AC1MWNTB     [1,3-dihydroxy-2- (hydroxymethyl)propan-2...

Synonyms: CHEBI:46097, ZINC00896695, DB03754, 3nm6, TRS, ...
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Disease relevance of Trizma


High impact information on Trizma


Chemical compound and disease context of Trizma


Biological context of Trizma

  • From the measurements at different concentrations of TRIS buffer acting as proton exchange catalyst, base pair lifetimes were evaluated [15].
  • From this we conclude that poly (rG-m5dC).poly (rG-m5dC) is in a regular A conformation in Tris buffer at low Na+ levels, shifting to an alternating A conformation with a dinucleotide repeat at intermediate salt concentrations [16].
  • These observations were made when intact cells were incubated either in a buffer which supported glycolysis or in a simple isotonic Tris buffer without glucose [17].
  • Quenching of bithiazole fluorescence by DNA was used to determine apparent equilibrium constants for the complex which, in 2.5 mM tris(hydroxymethyl)aminomethane buffer, pH 8.4, are 1.2 X 10(5) M-1 for bleomycin and 1.4 X 10(5) M-1 for tripeptide S, a partial acid hydrolysis product of the antibiotic [18].
  • The IC50 was 1-2 mM under a variety of conditions (i.e., whole tissue or synaptic membranes, frozen/thawed or fresh, D-[3H]aspartate (10-1000 nM) or L-[3H]glutamate (100 nM), phosphate or Tris buffer, NaCl or Na acetate, presence or absence of Ca2+ and Mg2+) [19].

Anatomical context of Trizma


Associations of Trizma with other chemical compounds


Gene context of Trizma

  • Sulfonated (Asn55-Ala107) SLPI was refolded in Tris buffer containing reduced and oxidized glutathione [30].
  • In the presence of 30 mM Na2SO4/50 mM Tris buffer, SP interacted with two types of binding sites with Kd values of 0.3 and 40 nM [31].
  • When native TPP II was dissociated into smaller units through dialysis against a dilute Tris buffer, it could be digested by chymotrypsin into three stable fragments of 70 kDa, 42 kDa and 20 kDa [32].
  • The lower ionic strength of the Tris buffer may underlie this effect. hBD-1 kills the M1 strain of GAS only in 10 mm Tris, but is able to kill an M6 (SIC negative) strain in 10 mm phosphate [33].
  • After dilution of plasma with low ionic Tris buffer and activation of the protease with barium chloride, a VWF concentrate is digested in the presence of urea [34].

Analytical, diagnostic and therapeutic context of Trizma


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