Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

IMPA methyl-propan-2-yloxy- phosphinic acid

Synonyms: AG-E-75185, NSC-289137, NSC-289175, NSC-289180, NSC-289393, ...

Vermillion, W.D. et al., Melanson, J.E. et al., D'Agostino, P.A. et al., Hui, D.M. et al., Weiss, D.J. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of isopropoxy-methyl-phosphinic acid

Acute toxicity of isopropyl methylphosphonic acid, a breakdown product of sarin, to eggs and fry of golden shiner and channel catfish [1].

High impact information on isopropoxy-methyl-phosphinic acid

Three soils, a red clay, a tan sandy clay and a brown sandy clay loam, were spiked with sarin and soman and their initial hydrolysis products, isopropyl methylphosphonic acid and pinacolyl methylphosphonic acid, at the 10 microg/g level to assess recovery efficiency [2].
Capillary electrophoresis coupled with indirect UV absorbance detection was employed for the determination of the chemical warfare agent degradation products: methylphosphonic acid, ethyl methylphosphonate, isopropyl methylphosphonate, and pinacolyl methylphosphonate [3].
The residual acetyicholine esterase activity of erythrocytes on admission (4.7-57.2% of the individual reference value) of the patients showed statistically significant relationships only with the initial values of F(-) and the isopropyl methylphosphonate [4].

Biological context of isopropoxy-methyl-phosphinic acid

Four mixed cultures were acclimated to the Sarin hydrolysis product, isopropyl methylphosphonic acid (IMPA) [5].

Associations of isopropoxy-methyl-phosphinic acid with other chemical compounds

The natural background of anions encountered when analyzing soil samples by ion chromatography (IC) present significant problems in the separation, detection and quantification of isopropyl methylphosphonic acid (IMPA) and methylphosphonic acid (MPA), the degradation products of sarin, a chemical warfare nerve agent [6].

Analytical, diagnostic and therapeutic context of isopropoxy-methyl-phosphinic acid

In both male and female mink and rats, DIMP was rapidly absorbed after oral administration; it was metabolized by a saturable pathway to a single metabolite, isopropyl methylphosphonate (IMPA), which was rapidly excreted, primarily in the urine (90%) [7].

References

Acute toxicity of isopropyl methylphosphonic acid, a breakdown product of sarin, to eggs and fry of golden shiner and channel catfish. Green, C.C., Lochmann, S.E., Straus, D.L. J. Toxicol. Environ. Health Part A (2005) [Pubmed]
Determination of sarin, soman and their hydrolysis products in soil by packed capillary liquid chromatography-electrospray mass spectrometry. D'Agostino, P.A., Hancock, J.R., Provost, L.R. Journal of chromatography. A. (2001) [Pubmed]
High-sensitivity determination of the degradation products of chemical warfare agents by capillary electrophoresis-indirect UV absorbance detection. Melanson, J.E., Wong, B.L., Boulet, C.A., Lucy, C.A. Journal of chromatography. A. (2001) [Pubmed]
Monitoring of fluorine in urine samples of patients involved in the tokyo sarin disaster, in connection with the detection of other decomposition products of sarin and the by-products generated during sarin synthesis. Hui, D.M., Minami, M. Clin. Chim. Acta (2000) [Pubmed]
Biodegradation of neutralized sarin. Zhang, Y., Autenrieth, R.L., Bonner, J.S., Harvey, S.P., Wild, J.R. Biotechnol. Bioeng. (1999) [Pubmed]
In-line respeciation: an ion-exchange ion chromatographic method applied to the separation of degradation products of chemical warfare nerve agents in soil. Vermillion, W.D., Crenshaw, M.D. Journal of chromatography. A. (1997) [Pubmed]
The comparative metabolism of diisopropyl methylphosphonate in mink and rats. Weiss, D.J., Geary, R.S., Wustenberg, W., Bucci, T.J., Perman, V., Baumel, I.P., Dacre, J.C. Arch. Environ. Contam. Toxicol. (1994) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.