Chemical Compound Review:
AGN-PC-0084PA methylphosphonic acid
Synonyms:
CHEMBL122938, AG-I-01423, ACMC-20ake9, CHEBI:45129, HSDB 6762, ...
- Inhibition of acquired immunodeficiency syndrome virus by oligodeoxynucleoside methylphosphonates. Sarin, P.S., Agrawal, S., Civeira, M.P., Goodchild, J., Ikeuchi, T., Zamecnik, P.C. Proc. Natl. Acad. Sci. U.S.A. (1988)
- pH homeostasis in Escherichia coli: measurement by 31P nuclear magnetic resonance of methylphosphonate and phosphate. Slonczewski, J.L., Rosen, B.P., Alger, J.R., Macnab, R.M. Proc. Natl. Acad. Sci. U.S.A. (1981)
- Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5. Smith, C.C., Aurelian, L., Reddy, M.P., Miller, P.S., Ts'o, P.O. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Guarding the genome: electrostatic repulsion of water by DNA suppresses a potent nuclease activity of topoisomerase IB. Tian, L., Claeboe, C.D., Hecht, S.M., Shuman, S. Mol. Cell (2003)
- Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4. Kulka, M., Smith, C.C., Aurelian, L., Fishelevich, R., Meade, K., Miller, P., Ts'o, P.O. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells. Moulding, D.A., Giles, R.V., Spiller, D.G., White, M.R., Tidd, D.M., Edwards, S.W. Blood (2000)
- Liposomal delivery of methylphosphonate antisense oligodeoxynucleotides in chronic myelogenous leukemia. Tari, A.M., Tucker, S.D., Deisseroth, A., Lopez-Berestein, G. Blood (1994)
- Down-regulation of c-MYC antigen expression in lymphocytes of Emu-c-myc transgenic mice treated with anti-c-myc DNA methylphosphonates. Wickstrom, E., Bacon, T.A., Wickstrom, E.L. Cancer Res. (1992)
- Induction of chronic human immunodeficiency virus infection is blocked in vitro by a methylphosphonate oligodeoxynucleoside targeted to a U3 enhancer element. Laurence, J., Sikder, S.K., Kulkosky, J., Miller, P., Ts'o, P.O. J. Virol. (1991)
- Mechanism of inhibition of the class C beta-lactamase of Enterobacter cloacae P99 by phosphonate monoesters. Rahil, J., Pratt, R.F. Biochemistry (1992)
- Triplex formation by psoralen-conjugated chimeric oligonucleoside methylphosphonates. Cassidy, R.A., Kondo, N.S., Miller, P.S. Biochemistry (2000)
- Mapping and molecular cloning of the phn (psiD) locus for phosphonate utilization in Escherichia coli. Wanner, B.L., Boline, J.A. J. Bacteriol. (1990)
- Two-generation reproductive study in mink fed diisopropyl methylphosphonate (DIMP). Bucci, T.J., Kovatch, R.M., Mercieca, M.D., Perman, V., Klingensmith, J.S. Reprod. Toxicol. (2003)
- Methylphosphonate mapping of phosphate contacts critical for RNA recognition by the human immunodeficiency virus tat and rev proteins. Pritchard, C.E., Grasby, J.A., Hamy, F., Zacharek, A.M., Singh, M., Karn, J., Gait, M.J. Nucleic Acids Res. (1994)
- Synthesis of specific diastereomers of a DNA methylphosphonate heptamer, d(CpCpApApApCpA), and stability of base pairing with the normal DNA octamer d(TPGPTPTPTPGPGPC). Vyazovkina, E.V., Savchenko, E.V., Lokhov, S.G., Engels, J.W., Wickstrom, E., Lebedev, A.V. Nucleic Acids Res. (1994)
- Duplex stabilities of phosphorothioate, methylphosphonate, and RNA analogs of two DNA 14-mers. Kibler-Herzog, L., Zon, G., Uznanski, B., Whittier, G., Wilson, W.D. Nucleic Acids Res. (1991)
- Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages. Shoji, Y., Akhtar, S., Periasamy, A., Herman, B., Juliano, R.L. Nucleic Acids Res. (1991)
- Molecular and crystal structure of Sp-thymidin-3'-yl 4-thiothymidin-5'-yl methylphosphonate. Szabó, T., Noréus, D., Norrestam, R., Stawinski, J. Nucleic Acids Res. (1993)
- Biotinylated antisense methylphosphonate oligodeoxynucleotides. Inhibition of spliceosome assembly and affinity selection of U1 and U2 small nuclear RNPs. Temsamani, J., Agrawal, S., Pederson, T. J. Biol. Chem. (1991)
- Comparative hybrid arrest by tandem antisense oligodeoxyribonucleotides or oligodeoxyribonucleoside methylphosphonates in a cell-free system. Maher, L.J., Dolnick, B.J. Nucleic Acids Res. (1988)
- Interactions of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes). Akhtar, S., Basu, S., Wickstrom, E., Juliano, R.L. Nucleic Acids Res. (1991)
- Effects of methylphosphonate, a phosphate analogue, on the expression and degradation of the high-affinity phosphate transporter Pho84, in Saccharomyces cerevisiae. Pratt, J.R., Mouillon, J.M., Lagerstedt, J.O., Pattison-Granberg, J., Lundh, K.I., Persson, B.L. Biochemistry (2004)
- Modeling of flap endonuclease interactions with DNA substrate. Allawi, H.T., Kaiser, M.W., Onufriev, A.V., Ma, W.P., Brogaard, A.E., Case, D.A., Neri, B.P., Lyamichev, V.I. J. Mol. Biol. (2003)
- Dimethyl methylphosphonate (DMMP): a 31P nuclear magnetic resonance spectroscopic probe of intracellular volume in mammalian cell cultures. Barry, J.A., McGovern, K.A., Lien, Y.H., Ashmore, B., Gillies, R.J. Biochemistry (1993)
- Short, strong hydrogen bonds at the active site of human acetylcholinesterase: proton NMR studies. Massiah, M.A., Viragh, C., Reddy, P.M., Kovach, I.M., Johnson, J., Rosenberry, T.L., Mildvan, A.S. Biochemistry (2001)
- Solid-phase syntheses of oligodeoxyribonucleoside methylphosphonates. Miller, P.S., Reddy, M.P., Murakami, A., Blake, K.R., Lin, S.B., Agris, C.H. Biochemistry (1986)
- Synthesis and in vitro properties of a powerful quaternary methylphosphonate inhibitor of acetylcholinesterase. A new marker in blood-brain barrier research. Levy, D., Ashani, Y. Biochem. Pharmacol. (1986)
- Reversible modification of tissue-type plasminogen activator by methylphosphonate esters. Zhao, O., Kovach, I.M. Bioorg. Med. Chem. (1996)
- Studies on anti-human immunodeficiency virus oligonucleotides that have alternating methylphosphonate/phosphodiester linkages. Miller, P.S., Cassidy, R.A., Hamma, T., Kondo, N.S. Pharmacol. Ther. (2000)
- Effect of ionic strength on the hybridization of oligodeoxynucleotides with reduced charge due to methylphosphonate linkages to unmodified oligodeoxynucleotides containing the complementary sequence. Quartin, R.S., Wetmur, J.G. Biochemistry (1989)
- Potentiometric sensing of chemical warfare agents: surface imprinted polymer integrated with an indium tin oxide electrode. Zhou, Y., Yu, B., Shiu, E., Levon, K. Anal. Chem. (2004)
- Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates. Rizk, S.S., Cuneo, M.J., Hellinga, H.W. Protein Sci. (2006)
- Antisense DNA oligonucleotides. II: The use of matrix-assisted laser desorption/ionization mass spectrometry for the sequence verification of methylphosphonate oligodeoxyribonucleotides. Keough, T., Baker, T.R., Dobson, R.L., Lacey, M.P., Riley, T.A., Hasselfield, J.A., Hesselberth, P.E. Rapid Commun. Mass Spectrom. (1993)