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Chemical Compound Review:

Terbucarb (4-methyl-2,6-ditert-butyl- phenyl) N...

Synonyms: Mbpmc, AZAC, AZAR, azak, Hercules 9573, ...

Suzuki, T. et al., Nakagawa, Y. et al., Suzuki, T. et al.

Suzuki, Nakagawa, Tayama, Yaguchi, Suga,

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High impact information on Terbutol

In an immunoinhibition study, T4MH activity in liver microsomes from 1% terbutol-treated rats was decreased about 50% by polyclonal anti-rat CYP2B1, whereas polyclonal anti-rat CYP2A1 and CYP2C11 did not affected the activity [1].
In male rats, P450 and cytochrome b5 (b5) contents, and NADPH cytochrome c reductase (fp2) activity in liver microsomes were increased about 2-fold by 1% terbutol administration for 7 to 28 days [1].
Metabolism of 3,5-di-t-butyl-4-methylphenyl N-methylcarbamate, Terbucarb, on isolated rat hepatocytes [2].

Associations of Terbutol with other chemical compounds

Comparative cytotoxicity between butylated hydroxytoluene and its methylcarbamate derivative, terbucarb, on isolated rat hepatocytes [3].

References

Toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic cytochrome P450 in F344 rats. Suzuki, T., Nakagawa, Y., Tayama, K., Yaguchi, K., Suga, T. Arch. Toxicol. (2001) [Pubmed]
Metabolism of 3,5-di-t-butyl-4-methylphenyl N-methylcarbamate, Terbucarb, on isolated rat hepatocytes. Suzuki, T., Yaguchi, K., Nakagawa, Y., Suga, T. Bulletin of environmental contamination and toxicology. (1995) [Pubmed]
Comparative cytotoxicity between butylated hydroxytoluene and its methylcarbamate derivative, terbucarb, on isolated rat hepatocytes. Nakagawa, Y., Yaguchi, K., Suzuki, T. Bulletin of environmental contamination and toxicology. (1994) [Pubmed]

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