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Chemical Compound Review

AGN-PC-0D877L     methylcarbamic acid

Synonyms: CHEBI:45379, AC1L1JRA, LS-69716, LS-191307, AKOS006291561, ...
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Disease relevance of methylcarbamic acid


High impact information on methylcarbamic acid


Chemical compound and disease context of methylcarbamic acid


Biological context of methylcarbamic acid


Associations of methylcarbamic acid with other chemical compounds


Gene context of methylcarbamic acid

  • Here we investigate the cytotoxicity and genotoxicity of N-methylcarbamate insecticides and their N-nitroso derivatives in Chinese hamster V79 cells, using the hprt locus as a marker, and also assess inhibition of gap junctional intercellular communication [4].
  • An enzyme with high specific affinity for organophosphate and N-methylcarbamate insecticides has been incorporated into a new test for detection of these insecticides at the level of parts per billion (ppb) (commercially available as the Charm Pesticide Test) [16].

Analytical, diagnostic and therapeutic context of methylcarbamic acid


  1. N-methylcarbamate derivatives of ellipticine and olivacine with cytotoxic activity against four human lung cancer cell lines. Ruckdeschel, J.C., Modi, S.P., el-Hamouly, W., Portuese, E., Archer, S. J. Med. Chem. (1992) [Pubmed]
  2. Purification and characterization of the N-methylcarbamate hydrolase from Pseudomonas strain CRL-OK. Mulbry, W.W., Eaton, R.W. Appl. Environ. Microbiol. (1991) [Pubmed]
  3. Structure-activity relationships of the N-methylcarbamate series in Salmonella typhimurium. Narbonne, J.F., Cassand, P., Alzieu, P., Grolier, P., Mrlina, G., Calmon, J.P. Mutat. Res. (1987) [Pubmed]
  4. Genetic toxicity of N-methylcarbamate insecticides and their N-nitroso derivatives. Wang, T.C., Chiou, C.M., Chang, Y.L. Mutagenesis (1998) [Pubmed]
  5. Genotoxicity of propoxur and its N-nitroso derivative in mammalian cells. Wang, T.C., Chiou, J.M., Chang, Y.L., Hu, M.C. Carcinogenesis (1998) [Pubmed]
  6. Synthesis and biological properties of some 6H-pyrido[4,3-b]carbazoles. Archer, S., Ross, B.S., Pica-Mattoccia, L., Cioli, D. J. Med. Chem. (1987) [Pubmed]
  7. Genotoxic evaluation of three heterocyclic N-methylcarbamate pesticides using the mouse bone marrow micronucleus assay and the Saccharomyces cerevisiae strains D7 and D61.M. Stehrer-Schmid, P., Wolf, H.U. Mutat. Res. (1995) [Pubmed]
  8. Optimization of the postcolumn hydrolysis reaction on solid phases for the routine high-performance liquid chromatographic determination of N-methylcarbamate pesticides in food products. De Kok, A., Hiemstra, M., Vreeker, C.P. J. Chromatogr. (1990) [Pubmed]
  9. Toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic cytochrome P450 in F344 rats. Suzuki, T., Nakagawa, Y., Tayama, K., Yaguchi, K., Suga, T. Arch. Toxicol. (2001) [Pubmed]
  10. Concerted role of carboxylesterases in the potentiation of carbofuran toxicity by iso-OMPA pretreatment. Gupta, R.C., Kadel, W.L. Journal of toxicology and environmental health. (1989) [Pubmed]
  11. High-performance liquid chromatographic determination of aryl N-methylcarbamate residues using post-column hydrolysis electrochemical detection. Krause, R.T. J. Chromatogr. (1988) [Pubmed]
  12. Quantitative structure-activity relationship of phenyl N-methylcarbamate inhibition of acetylcholinesterase. Goldblum, A., Yoshimoto, M., Hansch, C. J. Agric. Food Chem. (1981) [Pubmed]
  13. Tissue distribution of 14C-labeled residues of aminocarb in brown bullhead (Ictalurus nebulosus Le Sueur) following acute exposure. Richardson, G.M., Qadri, S.U. Ecotoxicol. Environ. Saf. (1986) [Pubmed]
  14. Contribution of monoaminergic nervous system in potentiation of 2-sec-butylphenyl N-methylcarbamate (BPMC) toxicity by malathion in male mice. Takahashi, H., Tanaka, J., Tsuda, S., Shirasu, Y. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1987) [Pubmed]
  15. Development of monoclonal antibody-based immunoassays to the N-methylcarbamate pesticide carbofuran. Abad, A., Moreno, M.J., Montoya, A. J. Agric. Food Chem. (1999) [Pubmed]
  16. Use of a new rapid bioluminescence method for screening organophosphate and N-Methylcarbamate insecticides in processed baby foods. Saul, S.J., Zomer, E., Puopolo, D., Charm, S.E. J. Food Prot. (1996) [Pubmed]
  17. Determination of N-methylcarbamate pesticides in well water by liquid chromatography with postcolumn fluorescence derivatization. Hill, K.M., Hollowell, R.H., Dal Cortivo, L.A. Anal. Chem. (1984) [Pubmed]
  18. Multi-residue analysis of N-methylcarbamate pesticides and their hydrolytic metabolites in environmental waters by use of solid-phase extraction and micellar electrokinetic chromatography. Molina, M., Pérez-Bendito, D., Silva, M. Electrophoresis (1999) [Pubmed]
  19. Cardiovascular collapse through non-cholinergic mechanism after intravenous injection of N-methylcarbamate insecticide in rabbits. Futagawa, H., Kakinuma, Y., Takahashi, H. Toxicology (1997) [Pubmed]
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