Disease relevance of methylcarbamic acid

• N-methylcarbamate derivatives of ellipticine and olivacine with cytotoxic activity against four human lung cancer cell lines [1].
• Purification and characterization of the N-methylcarbamate hydrolase from Pseudomonas strain CRL-OK [2].
• Structure-activity relationships of the N-methylcarbamate series in Salmonella typhimurium [3].
• Genetic toxicity of N-methylcarbamate insecticides and their N-nitroso derivatives [4].

High impact information on methylcarbamic acid

• N-Nitroso propoxur (NP) can be synthesized from a widely used N-methylcarbamate insecticide, propoxur, in vitro in the laboratory [5].
• 5-(Hydroxymethyl)-11-methyl-6H-pyrido[4,3-b]carbazole (46) and its N-methylcarbamate (48) were synthesized and their effect on macromolecular synthesis in HeLa cells and their antitumor properties were compared with those of ellipticine [6].
• Genotoxic evaluation of three heterocyclic N-methylcarbamate pesticides using the mouse bone marrow micronucleus assay and the Saccharomyces cerevisiae strains D7 and D61.M [7].
• Various solid-phase materials were evaluated as catalysts for the postcolumn hydrolysis of N-methylcarbamate pesticides in a high-performance liquid chromatographic (HPLC) method for food products [8].
• Toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic cytochrome P450 in F344 rats [9].

Chemical compound and disease context of methylcarbamic acid

• Pretreatment of rats with the nonspecific esterase inhibitor iso-OMPA (1 mg/kg sc) 1 h prior to carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl N-methylcarbamate, 0.5 mg/kg sc) administration potentiated carbofuran toxicity by more than threefold [10].

Biological context of methylcarbamic acid

• High-performance liquid chromatographic determination of aryl N-methylcarbamate residues using post-column hydrolysis electrochemical detection [11].
• Quantitative structure-activity relationship of phenyl N-methylcarbamate inhibition of acetylcholinesterase [12].
• Young brown bullhead (Ictalurus nebulosus) were exposed to aminocarb (4-dimethylamino-3-methylphenyl N-methylcarbamate) at lethal and sublethal concentrations and the tissue distribution of total unspecified residues was examined [13].
• When the inhibitory effect of each N-methylcarbamate on brain acetylcholinesterase (AChE) was compared with its LD50, among five N-methylcarbamates BPMC had particularly strong anti-AChE activity [14].

Associations of methylcarbamic acid with other chemical compounds

• Development of monoclonal antibody-based immunoassays to the N-methylcarbamate pesticide carbofuran [15].

Gene context of methylcarbamic acid

• Here we investigate the cytotoxicity and genotoxicity of N-methylcarbamate insecticides and their N-nitroso derivatives in Chinese hamster V79 cells, using the hprt locus as a marker, and also assess inhibition of gap junctional intercellular communication [4].
• An enzyme with high specific affinity for organophosphate and N-methylcarbamate insecticides has been incorporated into a new test for detection of these insecticides at the level of parts per billion (ppb) (commercially available as the Charm Pesticide Test) [16].

Analytical, diagnostic and therapeutic context of methylcarbamic acid

• Determination of N-methylcarbamate pesticides in well water by liquid chromatography with postcolumn fluorescence derivatization [17].
• A method for the simultaneous separation and determination of N-methylcarbamate pesticides and their hydrolytic metabolites by micellar electrokinetic chromatography (MEKC) was developed [18].
• Cardiovascular collapse through non-cholinergic mechanism after intravenous injection of N-methylcarbamate insecticide in rabbits [19].

References