Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Azaleucine (2S)-2-amino-3-dimethylamino- propanoic acid

Synonyms: L-4-Azaleucine, L-4-Azaleucin, AG-K-66341, AC1Q5QMU, CTK4I9995, ...

Harrison, L.I. et al., Sabina, J. et al., Eggeling, L. et al.

Eggeling, Sahm,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Azaleucine

Transport of L-4-azaleucine in Escherichia coli [1].
The ability of external azaleucine to exchange rapidly with intracellular leucine may be an important contributor to azaleucine toxicity [1].

High impact information on Azaleucine

4-Azaleucine, a competitive inhibitor of leucyl-tRNA synthetase, surprisingly triggered the heat shock response [2].
Experiments on the specificity of azaleucine uptake and exchange experiments with leucine and phenylalanine support the hypothesis that both LIV and aroP systems transport azaleucine [1].
Lesions in the aromatic amino acid transport system, aroP, also led to changes in the regulation of azaleucine uptake activity when cells were grown on phenylalanine [1].
BrnFE in C. glutamicum is a two-component permease exporting branched-chained amino acids from the cell, and an orthologue in B. subtilis exports 4-azaleucine [3].

References

Transport of L-4-azaleucine in Escherichia coli. Harrison, L.I., Christensen, H.N., Handlogten, M.E., Oxender, D.L., Quay, S.C. J. Bacteriol. (1975) [Pubmed]
Interfering with different steps of protein synthesis explored by transcriptional profiling of Escherichia coli K-12. Sabina, J., Dover, N., Templeton, L.J., Smulski, D.R., Söll, D., LaRossa, R.A. J. Bacteriol. (2003) [Pubmed]
New ubiquitous translocators: amino acid export by Corynebacterium glutamicum and Escherichia coli. Eggeling, L., Sahm, H. Arch. Microbiol. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share