The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Maprounic acid     (4aS,6aR,6bR,8aR,10S,12aS,14aS ,14bS)-10...

Synonyms: CHEMBL258249, SureCN438408, CHEBI:73107, AC1L4PLH, AC1Q5QYS, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Aleuritolic acid

  • A bioactivity-guided fractionation scheme resulted in the isolation of ursolic [IC50=100 micrograms/ml (216 microM)] and oleanolic [IC50=100 micrograms/ml (216 microM)] acids from Tricalysia niamniamensis Hiern (Rubiaceae), which demonstrated similar DNA ligase inhibition profiles to other triterpenes such as aleuritolic acid [1].
  • In our efforts to find new filaricidal agents against adult male O. gutturosa worms, we have isolated and screened three compounds: polycarpol and polyveoline from Polyalthia suaveolens (Annonaceae) and 3-O-acetyl aleuritolic acid from Discoglypremna caloneura (Euphorbiaceae) [2].
  • Dose-related DCTN and CTN inhibited in vivo the basal acid secretion in pylorus-ligature rats and oxyntic glands isolated from rabbit gastric mucosa, DCTN, CTN or AAA decreased in vitro uptake basal acid secretion induced by histamine and measured with the 14C-aminopyrine uptake method [3].

Analytical, diagnostic and therapeutic context of Aleuritolic acid


  1. Natural-product inhibitors of human DNA ligase I. Tan, G.T., Lee, S., Lee, I.S., Chen, J., Leitner, P., Besterman, J.M., Kinghorn, A.D., Pezzuto, J.M. Biochem. J. (1996) [Pubmed]
  2. Antifilarial activity in vitro of polycarpol and 3-O-acetyl aleuritolic acid from cameroonian medicinal plants against Onchocerca gutturosa. Nyasse, B., Ngantchou, I., Nono, J.J., Schneider, B. Nat. Prod. Res. (2006) [Pubmed]
  3. Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara. Maciel, M.A., Pinto, A.C., Arruda, A.C., Pamplona, S.G., Vanderlinde, F.A., Lapa, A.J., Echevarria, A., Grynberg, N.F., Côlus, I.M., Farias, R.A., Luna Costa, A.M., Rao, V.S. Journal of ethnopharmacology. (2000) [Pubmed]
WikiGenes - Universities