Disease relevance of Rubiaceae

• Toxicity of Palicourea marcgravii: combined effects of fluoroacetate, N-methyltyramine and 2-methyltetrahydro-beta-carboline [1].

High impact information on Rubiaceae

• Several members of the Rubiaceae and Violaceae families produce a series of cyclotides or macrocyclic peptides of 29-31 amino acids with an embedded cystine knot [2].
• Nucleotide sequence diversity at the methionine synthase locus in endangered Dunnia sinensis (Rubiaceae): an evaluation of the positive selection hypothesis [3].
• Circulin A belongs to a novel class of macrocyclic peptides which have been isolated from plants in the Rubiaceae family [4].
• A bioactivity-guided fractionation scheme resulted in the isolation of ursolic [IC50=100 micrograms/ml (216 microM)] and oleanolic [IC50=100 micrograms/ml (216 microM)] acids from Tricalysia niamniamensis Hiern (Rubiaceae), which demonstrated similar DNA ligase inhibition profiles to other triterpenes such as aleuritolic acid [5].
• Method limits of detection on a whole weight basis were 0.05 ppt for TCDD and 0.10 ppt for TCDF, 0.50 ppt for the pentas (PeCDDs/PeCDFs)/hexas (HxCDDs/HxCDFs)/heptas (HpCDDs/HpCDFs), and 3.00 ppt for the octas (OCDD/OCDF) [6].

Biological context of Rubiaceae

• Effect of cadmium on gene expression in the liverwort Lunularia cruciata [7].

Associations of Rubiaceae with chemical compounds

• New indole alkaloid glycosides from Nauclea orientalis [8].
• Quinovic acid glycosides from Nauclea diderrichii [9].
• This article represents the first reported isolation of this flavonoid from the Rubiaceae, as well as the first reported phytochemical and pharmacological investigation of the genus Strumpfia [10].
• In Cinchona robusta (Rubiaceae) cell suspension cultures, the activity of the enzyme isopentenyl-diphosphate isomerase (isopentenyl-POP isomerase) is transiently induced after addition of a homogenate of the phytopathogenic fungus Phytophthora cinnamomi [11].
• The ultrastructure of developmental stages of Goussia cruciata and the pathology they cause in the liver of Trachurus trachurus (Teleostei: Carangidae) caught off the Galician (North-West Spain) and Portuguese North Atlantic coasts are described [12].

Gene context of Rubiaceae

• Studies on antitumor cyclic hexapeptides RA obtained from rubiae radix, rubiaceae. VI. Minor antitumor constituents [13].
• Antioxidant properties of Lunularia cruciata (Bryophyta) extract [14].
• The highest population peak of Lu. cruciata was found in March with lesser peaks in February, December 1994, and January 1995 [15].
• The secretagogue effect of the poison from Centruroides limpidus limpidus on the pancreas of mice and the antagonistic action of the Bouvardia ternifolia extract [16].
• In vitro propagation of emetic nut Randia dumetorum (Lamb.) [17].

Analytical, diagnostic and therapeutic context of Rubiaceae

• To investigate the ability of Cd to affect gene transcription, the messenger RNA (mRNA) differential display technique was applied to the identification and isolation of genes whose transcription was altered in cultured Lunularia cruciata plants that were grown in the presence of cadmium salts [7].

References