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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Euphorbiaceae

  • (Euphorbiaceae) demonstrated a significant hypoglycemic activity in alloxan-induced diabetic rats but not in normal rats, at oral doses of 25 and 50 mg/kg body weight [1].
  • The effects of two nor-diterpenes, trans-dehydrocrotonin (DCTN) and trans-crotonin (CTN) from Croton cajucara (Euphorbiaceae), on the survival of mice bearing Sarcoma 180 and Ehrlich carcinoma ascitic tumours, on the proliferation of cultured Ehrlich cells and TNF alpha activity were determined [2].
  • A case report of severe skin and eye injury due to Excoecaria agallocha is presented to highlight the toxic nature of the latex of this common mangrove plant [3].

High impact information on Euphorbiaceae

  • EFN secretion by field-grown Macaranga tanarius increased after herbivory, artificial leaf damage, and exogenous jasmonic acid (JA) application [4].
  • Lipases of the euphorbiaceae family: purification of a lipase from Euphorbia characias latex and structure-function relationships with the B chain of ricin [5].
  • Among these, phorbol esters and other macrocyclic diterpene esters isolated from species of the families Euphorbiaceae and Thymelaeaceae were potent inducers of plasminogen activator [6].
  • In contrast, results from metabolic studies have suggested the involvement of a cytochrome P450 enzyme in vernolic acid synthesis in seeds of the Euphorbiaceae species Euphorbia lagascae [7].
  • We use cytochrome oxidase I (COI) to reconstruct phylogenetic relationships in a comprehensive sampling of the Decacrema inhabitants of Macaranga [8].

Chemical compound and disease context of Euphorbiaceae


Anatomical context of Euphorbiaceae

  • Twenty-eight picrotoxane terpenoids, including picrodendrins isolated from the Euphorbiaceae plant, Picrodendron baccatum (L.) Krug and Urban, have been evaluated for their ability to inhibit the specific binding of [3H]EBOB, the noncompetitive antagonist of ionotropic GABA receptors, to rat-brain and housefly (Musca domestica L.)-head membranes [9].
  • Inhibition of hydrogen peroxide, nitric oxide and TNF-alpha production in peritoneal macrophages by ethyl acetate fraction from Alchornea glandulosa [10].

Associations of Euphorbiaceae with chemical compounds


Gene context of Euphorbiaceae


Analytical, diagnostic and therapeutic context of Euphorbiaceae


  1. Hypoglycemic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara. Farias, R.A., Rao, V.S., Viana, G.S., Silveira, E.R., Maciel, M.A., Pinto, A.C. Planta Med. (1997) [Pubmed]
  2. Anti-tumour activity of two 19-nor-clerodane diterpenes, trans-dehydrocrotonin and trans-crotonin, from Croton cajucara. Grynberg, N.F., Echevarria, A., Lima, J.E., Pamplona, S.S., Pinto, A.C., Maciel, M.A. Planta Med. (1999) [Pubmed]
  3. Skin and eye injury due to latex of Excoecaria agallocha. Kumarasinghe, S.P., Seneviratne, R. Australas. J. Dermatol. (1998) [Pubmed]
  4. Extrafloral nectar production of the ant-associated plant, Macaranga tanarius, is an induced, indirect, defensive response elicited by jasmonic acid. Heil, M., Koch, T., Hilpert, A., Fiala, B., Boland, W., Linsenmair, K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Lipases of the euphorbiaceae family: purification of a lipase from Euphorbia characias latex and structure-function relationships with the B chain of ricin. Moulin, A., Teissère, M., Bernard, C., Piéroni, G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion. Wigler, M., DeFeo, D., Weinstein, I.B. Cancer Res. (1978) [Pubmed]
  7. Transgenic production of epoxy fatty acids by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed. Cahoon, E.B., Ripp, K.G., Hall, S.E., McGonigle, B. Plant Physiol. (2002) [Pubmed]
  8. Codiversification in an ant-plant mutualism: stem texture and the evolution of host use in Crematogaster (Formicidae: Myrmicinae) inhabitants of Macaranga (Euphorbiaceae). Quek, S.P., Davies, S.J., Itino, T., Pierce, N.E. Evolution (2004) [Pubmed]
  9. Picrodendrin and related terpenoid antagonists reveal structural differences between ionotropic GABA receptors of mammals and insects. Ozoe, Y., Akamatsu, M., Higata, T., Ikeda, I., Mochida, K., Koike, K., Ohmoto, T., Nikaido, T. Bioorg. Med. Chem. (1998) [Pubmed]
  10. Inhibition of hydrogen peroxide, nitric oxide and TNF-alpha production in peritoneal macrophages by ethyl acetate fraction from Alchornea glandulosa. Lopes, F.C., Calvo, T.R., Vilegas, W., Carlos, I.Z. Biol. Pharm. Bull. (2005) [Pubmed]
  11. Tumor promoters in commercial indoor-plant cultivars of the Euphorbiaceae. Vogg, G., Mattes, E., Polack, A., Sandermann, H. Environ. Health Perspect. (1999) [Pubmed]
  12. Antitumor agents from Jatropha macrorhiza (Euphorbiaceae) III: acetylaleuritolic acid. Torrance, S.J., Wiedhopf, R.M., Cole, J.R. Journal of pharmaceutical sciences. (1977) [Pubmed]
  13. Action of 2-hydroxy-4,6-dimethoxyacetophenone isolated from Sebastiania schottiana. Calixto, J.B., Miguel, O.G., Yunes, R.A., Rae, G.A. Planta Med. (1990) [Pubmed]
  14. Structure analysis of an allene-containing estolide tetraester triglyceride in the seed oil of Sebastiana commersoniana (Euphorbiaceae). Spitzer, V., Tomberg, W., Pohlentz, G. Lipids (1997) [Pubmed]
  15. Seco diterpenoids from Excoecaria agallocha L. Anjaneyulu, A.S., Rao, V.L. Phytochemistry (2003) [Pubmed]
  16. Antiulcerogenic activity of Alchornea castaneaefolia: effects on somatostatin, gastrin and prostaglandin. Hiruma-Lima, C.A., Calvo, T.R., Rodrigues, C.M., Andrade, F.D., Vilegas, W., Brito, A.R. Journal of ethnopharmacology. (2006) [Pubmed]
  17. Identification of profilin as an IgE-binding component in latex from Hevea brasiliensis: clinical implications. Vallier, P., Balland, S., Harf, R., Valenta, R., Deviller, P. Clin. Exp. Allergy (1995) [Pubmed]
  18. Dietary cancer risk conditional cancerogens in produce of livestock fed on species of spurge (Euphorbiaceae). I. Skin irritant and tumor-promoting ingenane-type diterpene esters in E. peplus, one of several herbaceous Euphorbia species contaminating fodder of livestock. Zayed, S.M., Farghaly, M., Taha, H., Gotta, H., Hecker, E. J. Cancer Res. Clin. Oncol. (1998) [Pubmed]
  19. Investigations of medicinal plants of euphorbiaceae and thymelaeaceae occurring and used in Thailand; II. Cryptic irritants of the diterpene ester type from three Excoecaria species. Wiriyachitra, P., Hajiwangoh, H., Boonton, P., Adolf, W., Opferkuch, H.J., Hecker, E. Planta Med. (1985) [Pubmed]
  20. Plant antitumor agents, 19. Novel triterpenes from Maprounea africana. Wani, M.C., Schaumberg, J.P., Taylor, H.L., Thompson, J.B., Wall, M.E. J. Nat. Prod. (1983) [Pubmed]
  21. Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extract. Chattopadhyay, D., Arunachalam, G., Mandal, A.B., Sur, T.K., Mandal, S.C., Bhattacharya, S.K. Journal of ethnopharmacology. (2002) [Pubmed]
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