Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-J-03168 5-[(5-methyl-2,4-dioxo-1,3- diazinan-5...

Synonyms: AC1L4PPN, AC1Q6CHJ, CTK4G0834, AR-1G6593, AR-1G6594, ...

Lindberg, C. et al., Slieman, T.A. et al., Rebeil, R. et al., Setlow, P.

Setlow,

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Disease relevance of 5-Thyminyl-5,6-dihydrothymine

The major DNA photoproduct of dormant, UV-irradiated Bacillus subtilis spores is the thymine dimer 5-thyminyl-5,6-dihydrothymine [spore photoproduct (SP)] [1].

High impact information on 5-Thyminyl-5,6-dihydrothymine

The predominant photolesion in the DNA of UV-irradiated dormant bacterial spores is the thymine dimer 5-thyminyl-5,6-dihydrothymine, commonly referred to as spore photoproduct (SP) [2].
1) called spore photoproduct (SP; 5-thyminyl-5,6-dihydrothymine); and b) DNA repair, in particular SP-specific repair, during spore germination [3].
In addition to the "spore photoproduct" 5-thyminyl-5,6-dihydrothymine (TDHT), which is produced in response to irradiation at atmospheric pressure, two additional photoproducts, known as the cis-syn and trans-syn isomers of thymine dimer, are produced on irradiation in vacuo [4].

References

The subunit structure and catalytic mechanism of the Bacillus subtilis DNA repair enzyme spore photoproduct lyase. Rebeil, R., Nicholson, W.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
Spore photoproduct (SP) lyase from Bacillus subtilis specifically binds to and cleaves SP (5-thyminyl-5,6-dihydrothymine) but not cyclobutane pyrimidine dimers in UV-irradiated DNA. Slieman, T.A., Rebeil, R., Nicholson, W.L. J. Bacteriol. (2000) [Pubmed]
Resistance of spores of Bacillus species to ultraviolet light. Setlow, P. Environ. Mol. Mutagen. (2001) [Pubmed]
Action spectra for survival and spore photoproduct formation of Bacillus subtilis irradiated with short-wavelength (200-300 nm) UV at atmospheric pressure and in vacuo. Lindberg, C., Horneck, G. J. Photochem. Photobiol. B, Biol. (1991) [Pubmed]

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