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Chemical Compound Review:

XOAA 2-(9-oxoxanthen-4-yl)ethanoic acid

Synonyms: CHEMBL28715, SureCN107952, AG-J-59146, CTK1C4240, NSC677590, ...

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Disease relevance of Xanthanone-acetic acid

Cytokine induction and therapeutic synergy with interleukin-2 against murine renal and colon cancers by xanthenone-4-acetic acid derivatives [1].

High impact information on Xanthanone-acetic acid

Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid [2].
Structure-activity relationships for substituted 9-oxo-9,10-dihydroacridine-4-acetic acids: analogues of the colon tumour active agent xanthenone-4-acetic acid [3].
Plasma pharmacokinetics of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in mice [4].
New derivatives of xanthenone-4-acetic acid: Synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells [5].

Analytical, diagnostic and therapeutic context of Xanthanone-acetic acid

Determination of xanthenone-4-acetic acid in mouse plasma by high-performance liquid chromatography [6].

References

Cytokine induction and therapeutic synergy with interleukin-2 against murine renal and colon cancers by xanthenone-4-acetic acid derivatives. Futami, H., Eader, L., Back, T.T., Gruys, E., Young, H.A., Wiltrout, R.H., Baguley, B.C. J. Immunother. (1992) [Pubmed]
Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid. Thomsen, L.L., Ching, L.M., Baguley, B.C. Cancer Res. (1990) [Pubmed]
Structure-activity relationships for substituted 9-oxo-9,10-dihydroacridine-4-acetic acids: analogues of the colon tumour active agent xanthenone-4-acetic acid. Gamage, S.A., Rewcastle, G.W., Atwell, G.J., Baguley, B.C., Denny, W.A. Anticancer Drug Des. (1992) [Pubmed]
Plasma pharmacokinetics of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in mice. McKeage, M.J., Kestell, P., Denny, W.A., Baguley, B.C. Cancer Chemother. Pharmacol. (1991) [Pubmed]
New derivatives of xanthenone-4-acetic acid: Synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells. Gobbi, S., Belluti, F., Bisi, A., Piazzi, L., Rampa, A., Zampiron, A., Barbera, M., Caputo, A., Carrara, M. Bioorg. Med. Chem. (2006) [Pubmed]
Determination of xanthenone-4-acetic acid in mouse plasma by high-performance liquid chromatography. Kestell, P., McKeage, M.J., Baguley, B.C. J. Chromatogr. (1991) [Pubmed]

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