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Chemical Compound Review

Mitoflaxona     2-(4-oxo-2-phenyl-chromen-8- yl)ethanoic acid

Synonyms: Mitoflaxone, Mitoflaxonum, CHEMBL443793, SureCN106705, LM-975, ...
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Disease relevance of LM-975


High impact information on LM-975


Chemical compound and disease context of LM-975


Biological context of LM-975


Anatomical context of LM-975

  • The investigational drug flavone-8-acetic acid (FAA) potently augments NK activity in the spleen, liver, lungs, and peritoneum in a dose-dependent manner after i.v. or i.p. administration [3].
  • A range of 17 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A [16].
  • Hyporesponsiveness of macrophages from C3H/HeJ (endotoxin-resistant) mice to the antitumour agent flavone acetic acid (NSC 347512) [17].

Associations of LM-975 with other chemical compounds


Gene context of LM-975


Analytical, diagnostic and therapeutic context of LM-975


  1. Immune thrombocytopenia caused by flavone-8-acetic acid. Davis, H.P., Newlands, E.S., Allain, T., Hegde, U. Lancet (1988) [Pubmed]
  2. Partial degradation of T-cell signal transduction molecules by contaminating granulocytes during protein extraction of splenic T cells from tumor-bearing mice. Franco, J.L., Ghosh, P., Wiltrout, R.H., Carter, C.R., Zea, A.H., Momozaki, N., Ochoa, A.C., Longo, D.L., Sayers, T.J., Komschlies, K.L. Cancer Res. (1995) [Pubmed]
  3. Flavone-8-acetic acid augments systemic natural killer cell activity and synergizes with IL-2 for treatment of murine renal cancer. Wiltrout, R.H., Boyd, M.R., Back, T.C., Salup, R.R., Arthur, J.A., Hornung, R.L. J. Immunol. (1988) [Pubmed]
  4. Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts. Giavazzi, R., Garofalo, A., Damia, G., Garattini, S., D'Incalci, M. Br. J. Cancer (1988) [Pubmed]
  5. Flavone acetic acid (FAA) with recombinant interleukin-2 (TIL-2) in advanced malignant melanoma. II: Induction of nitric oxide production. Thomsen, L.L., Baguley, B.C., Rustin, G.J., O'Reilly, S.M. Br. J. Cancer (1992) [Pubmed]
  6. Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth. Ghosh, P., Komschlies, K.L., Cippitelli, M., Longo, D.L., Subleski, J., Ye, J., Sica, A., Young, H.A., Wiltrout, R.H., Ochoa, A.C. J. Natl. Cancer Inst. (1995) [Pubmed]
  7. Flavone-8-acetic acid inhibits ristocetin-induced platelet agglutination and prolongs bleeding time. Rubin, J., Ames, M.M., Schutt, A.J., Nichols, W.L., Bowie, E.J., Kovach, J.S. Lancet (1987) [Pubmed]
  8. Alterations in NF kappa B/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy. Ghosh, P., Sica, A., Young, H.A., Ye, J., Franco, J.L., Wiltrout, R.H., Longo, D.L., Rice, N.R., Komschlies, K.L. Cancer Res. (1994) [Pubmed]
  9. Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid. Thomsen, L.L., Ching, L.M., Baguley, B.C. Cancer Res. (1990) [Pubmed]
  10. Application of a new preclinical drug screening system for cancer of the large bowel. Scheithauer, W., Moyer, M.P., Clark, G.M., Von Hoff, D.D. Cancer Chemother. Pharmacol. (1988) [Pubmed]
  11. Potential antitumor agents. 62. Structure-activity relationships for tricyclic compounds related to the colon tumor active drug 9-oxo-9H-xanthene-4-acetic acid. Rewcastle, G.W., Atwell, G.J., Palmer, B.D., Boyd, P.D., Baguley, B.C., Denny, W.A. J. Med. Chem. (1991) [Pubmed]
  12. Plasma pharmacokinetics of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in mice. McKeage, M.J., Kestell, P., Denny, W.A., Baguley, B.C. Cancer Chemother. Pharmacol. (1991) [Pubmed]
  13. Decarboxylation of the antitumour drugs flavone-8-acetic acid and xanthenone-4-acetic acid by nitrogen dioxide. Everett, S.A., Candeias, L.P., Denny, W.A., Wardman, P. Anticancer Drug Des. (1994) [Pubmed]
  14. Inhibiting the repair of DNA damage induced by gamma irradiation in rat thymocytes. Smit, J.A., Stark, J.H. Radiat. Res. (1994) [Pubmed]
  15. The structure of flavone-8-acetic acid, a chemotherapeutic agent, and its application to drug design. Rabinovitz, M. J. Enzym. Inhib. (1988) [Pubmed]
  16. Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 1: 6-Methyl derivatives. Aitken, R.A., Bibby, M.C., Double, J.A., Phillips, R.M., Sharma, S.K. Arch. Pharm. (Weinheim) (1996) [Pubmed]
  17. Hyporesponsiveness of macrophages from C3H/HeJ (endotoxin-resistant) mice to the antitumour agent flavone acetic acid (NSC 347512). Ching, L.M., Baguley, B.C. European journal of cancer & clinical oncology. (1989) [Pubmed]
  18. Interaction between flavone acetic acid (LM-975, NSC 349512) and radiation in Glasgow's osteogenic sarcoma in vivo. De Neve, W., Evelhoch, J., Everett, C., Simpson, N., Bissery, M.C., Corbett, T., Valeriote, F. Int. J. Radiat. Oncol. Biol. Phys. (1990) [Pubmed]
  19. Induction of STAT and NFkappaB activation by the antitumor agents 5,6-dimethylxanthenone-4-acetic acid and flavone acetic acid in a murine macrophage cell line. Ching, L.M., Young, H.A., Eberly, K., Yu, C.R. Biochem. Pharmacol. (1999) [Pubmed]
  20. Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. III. Antimetabolites, tubulin-binding agents, platinum drugs, amsacrine, L-asparaginase, interferons, steroids and other miscellaneous antitumor agents. Bosanquet, A.G. Cancer Chemother. Pharmacol. (1989) [Pubmed]
  21. Modulation of luminol-dependent chemiluminescence of murine macrophages by flavone and its synthetic derivatives. Król, W., Czuba, Z.P., Threadgill, M.D., Cunningham, B.D., Shani, J. Arzneimittel-Forschung. (1995) [Pubmed]
  22. Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13. Bauvois, B., Puiffe, M.L., Bongui, J.B., Paillat, S., Monneret, C., Dauzonne, D. J. Med. Chem. (2003) [Pubmed]
  23. Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. Sun, J.R., Brown, J.M. Cancer Res. (1989) [Pubmed]
  24. Nitric oxide production in endotoxin-resistant C3H/HeJ mice stimulated with flavone-8-acetic acid and xanthenone-4-acetic acid analogues. Thomsen, L.L., Ching, L.M., Joseph, W.R., Baguley, B.C., Gavin, J.B. Biochem. Pharmacol. (1992) [Pubmed]
  25. Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Phillips, R.M. Biochem. Pharmacol. (1999) [Pubmed]
  26. Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 4: Variation of the basic structure. Aitken, R.A., Bibby, M.C., Cooper, P.A., Double, J.A., Laws, A.L., Ritchie, R.B., Wilson, D.W. Arch. Pharm. (Weinheim) (2000) [Pubmed]
  27. Stability of flavone-8-acetic acid (LM975) in aqueous solutions by high-performance liquid chromatography. Betteridge, R.F., Land, C.P., Bosanquet, A.G. Journal of pharmaceutical and biomedical analysis. (1988) [Pubmed]
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