Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AG-K-18423 2-(azepan-4-yl)-4-[(4- chlorophenyl)methyl]...

Synonyms: CHEMBL2074921, SureCN2820100, ANW-42345, KST-1B5268, KST-1B5269, ...

Adusumalli, V.E. et al., Richards, I.S. et al., Nakajima, M. et al., Pivonka, J. et al., Yang, J.T. et al.

Nakajima, Ohyama, Nakamura, Shimada, Yamazaki, Yokoi,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Desmethylazelastine

Azelastine and desmethylazelastine competitively inhibited CYP3A4 activity (Ki = 23. 7 +/- 4.6 and 13.2 +/- 2.3 microM) [1].
Pharmacokinetics of azelastine (AZ) and its major active metabolite desmethylazelastine (DAZ) after iv or po administration of 1 mg/kg [14C]AZ hydrochloride or unlabeled AZ hydrochloride were studied in guinea pigs [2].
Pharmacokinetics of azelastine and its active metabolite, desmethylazelastine, in guinea pigs [2].
The major metabolite in bile, urine, and feces was the 7-ACID, with much less AZ and DAZ present [3].
We examined the effects of a new anti-asthmatic drug, azelastine, and its principal metabolite, desmethylazelastine, on the in vitro electromechanical response of human airway smooth muscle during cholinergic stimulation [4].

Analytical, diagnostic and therapeutic context of Desmethylazelastine

Determination of azelastine and desmethylazelastine in human plasma by high-performance liquid chromatography [5].

References

Inhibitory effects of azelastine and its metabolites on drug oxidation catalyzed by human cytochrome P-450 enzymes. Nakajima, M., Ohyama, K., Nakamura, S., Shimada, N., Yamazaki, H., Yokoi, T. Drug Metab. Dispos. (1999) [Pubmed]
Pharmacokinetics of azelastine and its active metabolite, desmethylazelastine, in guinea pigs. Adusumalli, V.E., Wong, K.K., Kucharczyk, N., Sofia, R.D. Drug Metab. Dispos. (1992) [Pubmed]
Metabolism of [14C]azelastine in guinea pigs. Yang, J.T., Wong, K.K., Kucharczyk, N., Sofia, R.D. Drug Metab. Dispos. (1992) [Pubmed]
Azelastine and desmethylazelastine suppress acetylcholine-induced contraction and depolarization in human airway smooth muscle. Richards, I.S., Miller, L., Solomon, D., Kulkarni, A., Brooks, S., Sperelakis, N. Eur. J. Pharmacol. (1990) [Pubmed]
Determination of azelastine and desmethylazelastine in human plasma by high-performance liquid chromatography. Pivonka, J., Segelman, F.H., Hartman, C.A., Segl, W.E., Kucharczyk, N., Sofia, R.D. J. Chromatogr. (1987) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share