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Chemical Compound Review:

AG-K-89298 3-(2-aminoethyl)cyclohexa- 2,4-diene-1,6-dione

Synonyms: CHEBI:74684, HMDB12219, SureCN12023988, AC1Q6BWP, CTK4J2981, ...

Milusheva, E. et al., Teismann, P. et al., Baranyi, M. et al., Xu, Y. et al., Asanuma, M. et al., et al.

Asanuma, Miyazaki, Ogawa, Baranyi, Milusheva, Vizi, Sperlágh,

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Disease relevance of Dopamine quinone

Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease [1].

High impact information on Dopamine quinone

Instead, we provide evidence that COX-2 inhibition prevents the formation of the oxidant species dopamine-quinone, which has been implicated in the pathogenesis of PD [2].
Striatal dopaminergic neurons showed increased susceptibility to oxidative stress by H(2)O(2), responding with enhanced release of DA and with formation of an unidentified metabolite, which is most likely the toxic dopamine quinone (DAQ) [3].
One of the potential targets in brain for dopamine quinone damage is tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis [4].
Mechanistic studies of melanogenesis: the influence of N-substitution on dopamine quinone cyclization [5].

Associations of Dopamine quinone with other chemical compounds

Sensitivity of dopaminergic neurons were increased to oxidative stress with enhanced release of dopamine and formation of oxidized metabolite dopamine quinone (DAQ) [6].

References

Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease. Asanuma, M., Miyazaki, I., Ogawa, N. Neurotoxicity research. (2003) [Pubmed]
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Teismann, P., Tieu, K., Choi, D.K., Wu, D.C., Naini, A., Hunot, S., Vila, M., Jackson-Lewis, V., Przedborski, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Increased sensitivity of striatal dopamine release to H2O2 upon chronic rotenone treatment. Milusheva, E., Baranyi, M., Kittel, A., Sperlágh, B., Vizi, E.S. Free Radic. Biol. Med. (2005) [Pubmed]
Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase. Xu, Y., Stokes, A.H., Roskoski, R., Vrana, K.E. J. Neurosci. Res. (1998) [Pubmed]
Mechanistic studies of melanogenesis: the influence of N-substitution on dopamine quinone cyclization. Borovansky, J., Edge, R., Land, E.J., Navaratnam, S., Pavel, S., Ramsden, C.A., Riley, P.A., Smit, N.P. Pigment Cell Res. (2006) [Pubmed]
Chromatographic analysis of dopamine metabolism in a Parkinsonian model. Baranyi, M., Milusheva, E., Vizi, E.S., Sperlágh, B. Journal of chromatography. A. (2006) [Pubmed]

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