Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL214013 4-amino-N-[2-[[N-cyano-N'-[3- [3-(1...

Synonyms: AC1L4URS, AR-1G0811, AC1Q5RJ7

This record was replaced with 164435.

Zawilska, J.B. et al., Nowak, J.Z. et al., Zawilska, J.B. et al.

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High impact information on 4-amino-N-[2-[[N-cyano-N'-[3-[3-(1-piperidylmethyl)phenoxy]propyl]carbamimidoyl]amino]ethyl]benzamide

The relative rank order of HA-ergic drugs to inhibit [(3) H]tiotidine binding to chick cerebrum was: antagonists - tiotidine >> aminopotentidine = ranitidine >or= zolantadine >> thioperamide - triprolidine; agonists - HA >or= 4-methylHA >> 2-methylHA >or=R alpha-methylHA - dimaprit [1].
The stimulatory effect of HA on IP3 levels was antagonized by aminopotentidine, a potent blocker of H2-like HA receptors in avian pineal gland [2].
A combination of VIP and histamine produced the cyclic AMP response in the pineal gland clearly more than additive; such a synergistic interaction was antagonized by aminopotentidine, an accepted in mammals H2-histamine receptor blocker [3].

References

Histamine H(2) -like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [(3) H]tiotidine binding. Zawilska, J.B., Woldan-Tambor, A., Nowak, J.Z. J. Neurochem. (2002) [Pubmed]
Histamine-stimulated cyclic AMP formation in the chick pineal gland: role of protein kinase C. Zawilska, J.B., Woldan-Tambor, A., Nowak, J.Z. Biochem. Pharmacol. (1997) [Pubmed]
A synergistic interaction between histamine and vasoactive intestinal peptide (VIP) on cyclic AMP production in the chick pineal gland. Nowak, J.Z., Woldan-Tambor, A., Kuba, K., Zawilska, J.B. J. Physiol. Pharmacol. (1998) [Pubmed]

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