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Chemical Compound Review

triprolidine     2-[(Z)-1-(4-methylphenyl)-3- pyrrolidin-1...

Synonyms: Lopac-T-6764, Tocris-0662, AC1LEMD5, SureCN3881294, AC1Q4YLI, ...
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Disease relevance of triprolidine


Psychiatry related information on triprolidine


High impact information on triprolidine


Biological context of triprolidine


Anatomical context of triprolidine


Associations of triprolidine with other chemical compounds


Gene context of triprolidine


Analytical, diagnostic and therapeutic context of triprolidine


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  2. H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells. Jangi, S.M., Díaz-Pérez, J.L., Ochoa-Lizarralde, B., Martín-Ruiz, I., Asumendi, A., Pérez-Yarza, G., Gardeazabal, J., Díaz-Ramón, J.L., Boyano, M.D. Carcinogenesis (2006) [Pubmed]
  3. Microbial transformation of the antihistaminic drug triprolidine hydrochloride. Hansen, E.B., Heflich, R.H., Korfmacher, W.A., Miller, D.W., Cerniglia, C.E. Journal of pharmaceutical sciences. (1988) [Pubmed]
  4. Comparison of pseudoephedrine and triprolidine, alone and in combination in preventing nasal congestion in subjects with allergic rhinitis using nasal histamine challenge. Empey, D.W., Frosolono, M.F., Hughes, D.T., Perkins, J.G. British journal of clinical pharmacology. (1984) [Pubmed]
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  16. Effects of triprolidine and dipipanone in the cold induced pain test, and the central nervous system of healthy volunteers. Telekes, A., Holland, R.L., Withington, D.A., Peck, A.W. British journal of clinical pharmacology. (1987) [Pubmed]
  17. Effect of inflammatory mediators on the electrophysiology of the human oviduct. Downing, S.J., Chambers, E.L., Maguiness, S.D., Watson, A., Leese, H.J. Biol. Reprod. (1999) [Pubmed]
  18. Disposition and metabolism of triprolidine in mice. Deal, D.L., Chandrasurin, P., Shockcor, J., Minick, D.J., Findlay, J.W., McNulty, M.J. Drug Metab. Dispos. (1992) [Pubmed]
  19. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Findlay, J.W., Butz, R.F., Sailstad, J.M., Warren, J.T., Welch, R.M. British journal of clinical pharmacology. (1984) [Pubmed]
  20. Enhanced efficacy of triprolidine by transdermal application of the EVA matrix system in rabbits and rats. Shin, S.C., Choi, J.S. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2005) [Pubmed]
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  22. A role for endogenous histamine in interleukin-8-induced neutrophil infiltration into mouse air-pouch: investigation of the modulatory action of systemic and local dexamethasone. Perretti, M., Harris, J.G., Flower, R.J. Br. J. Pharmacol. (1994) [Pubmed]
  23. Cortical acetylcholine release elicited by stimulation of histamine H1 receptors in the nucleus basalis magnocellularis: a dual-probe microdialysis study in the freely moving rat. Cecchi, M., Passani, M.B., Bacciottini, L., Mannaioni, P.F., Blandina, P. Eur. J. Neurosci. (2001) [Pubmed]
  24. Inhibition of cortical acetylcholine release and cognitive performance by histamine H3 receptor activation in rats. Blandina, P., Giorgetti, M., Bartolini, L., Cecchi, M., Timmerman, H., Leurs, R., Pepeu, G., Giovannini, M.G. Br. J. Pharmacol. (1996) [Pubmed]
  25. H1-receptor antagonists. Comparative tolerability and safety. Simons, F.E. Drug safety : an international journal of medical toxicology and drug experience. (1994) [Pubmed]
  26. Histamine and histamine-receptor antagonists modify gene expression and biosynthesis of interferon gamma in peripheral human blood mononuclear cells and in CD19-depleted cell subsets. Horváth, B.V., Szalai, C., Mándi, Y., László, V., Radvány, Z., Darvas, Z., Falus, A. Immunol. Lett. (1999) [Pubmed]
  27. Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. Szeberényi, J.B., Pállinger, E., Zsinkó, M., Pós, Z., Rothe, G., Orsó, E., Szeberényi, S., Schmitz, G., Falus, A., László, V. Immunol. Lett. (2001) [Pubmed]
  28. The effects of single and repeated administration of ebastine on cognition and psychomotor performance in comparison to triprolidine and placebo in healthy volunteers. Hindmarch, n.u.l.l., Shamsi, Z. Current medical research and opinion. (2001) [Pubmed]
  29. A comparison of triprolidine and cyclizine on histamine (H1) antagonism, subjective effects and performance tests in man. Hamilton, M., Bush, M., Bye, C., Peck, A.W. British journal of clinical pharmacology. (1982) [Pubmed]
  30. Disposition of triprolidine in the male beagle dog. McNulty, M.J., Deal, D.L., Page, T.L., Chandrasurin, P., Findlay, J.W. Drug Metab. Dispos. (1992) [Pubmed]
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