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Chemical Compound Review:

Ononitol (1R,2S,4S,5S)-6- methoxycyclohexane-1,2,3,4...

Synonyms: Pinnitol, Sennitol, Inzitol, Pinitol, Pinit, ...

Morinaga, T. et al., Kang, M.J. et al., Bates, S.H. et al., Campbell, W.W. et al.

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Disease relevance of D-Pinitol

The effect of 3-O-methyl-D-chiro-inositol (D-pinitol), purified from soybean, on the postprandial blood glucose response in patients with type 2 diabetes mellitus was examined [1].
Soybeans are rich in pinitol (PI; 3-O-methyl-D-chiro-inositol), which improves health by treating conditions associated with insulin resistance, such as diabetes mellitus and obesity [2].

High impact information on D-Pinitol

Incubation of L6 muscle cells with D-pinitol (10(-3) M) increased basal 2DG uptake by 41% after 10 min and by 34% after 4 h [3].
C-peptide AUC was greater in the men versus the women (p < 0.001) [4].

References

Pinitol from soybeans reduces postprandial blood glucose in patients with type 2 diabetes mellitus. Kang, M.J., Kim, J.I., Yoon, S.Y., Kim, J.C., Cha, I.J. Journal of medicinal food. (2006) [Pubmed]
Functional myo-Inositol Catabolic Genes of Bacillus subtilis Natto Are Involved in Depletion of Pinitol in Natto (Fermented Soybean). Morinaga, T., Yamaguchi, M., Makino, Y., Nanamiya, H., Takahashi, K., Yoshikawa, H., Kawamura, F., Ashida, H., Yoshida, K. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
Insulin-like effect of pinitol. Bates, S.H., Jones, R.B., Bailey, C.J. Br. J. Pharmacol. (2000) [Pubmed]
Relationships of plasma C-peptide and gender to the urinary excretion of inositols in older people. Campbell, W.W., Ostlund, R.E., Joseph, L.J., Farrell, P.A., Evans, W.J. Horm. Metab. Res. (2001) [Pubmed]

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