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Chemical Compound Review: 

Coryneine     2-(3,4-dihydroxyphenyl)ethyl- trimethyl...

Synonyms: SureCN4824806, AC1L4WWC, AC1Q7ACS, AR-1C7091, C17486, ...
 
 
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High impact information on NSC42278

  • The activity of m-hydroxybenzyltrimethylammonium, coryneine (3:4-dihydroxyphenethyltrimethylammonium, 'quaternary dopamine'), and m-hydroxyphenylpropyltrimethylammonium relative to tetramethylammonium has been measured on the frog rectus preparation (Rana pipiens) at pH 7 and pH 9 [1].
  • These results suggest that of the two components contained in aconite root, higenamine increases ACh release via activation of beta-adrenoceptor, and conversely coryneine depresses ACh release by preferentially acting at motor nerve terminal [2].
 

Analytical, diagnostic and therapeutic context of NSC42278

References

  1. The effects of pH on the activity of coryneine and related phenolic quaternary ammonium salts on the frog rectus preparation. Barlow, R.B. Br. J. Pharmacol. (1976) [Pubmed]
  2. Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice. Nojima, H., Okazaki, M., Kimura, I. Journal of Asian natural products research. (2000) [Pubmed]
  3. Depolarizing neuromuscular blocking action of coryneine derived from aconite root in isolated mouse phrenic nerve-diaphragm muscles. Kimura, M., Kimura, I., Muroi, M., Nojima, H., Diwan, P.V. Biol. Pharm. Bull. (1995) [Pubmed]
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