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Chemical Compound Review:

Metaoxon 4-dimethoxyphosphoryloxy-2- methyl-1-nitro...

Synonyms: Sumioxon, Sumioxone, Fenitroxon, Fenitrooxon, Fenitrooxone, ...

Johnston, J.J. et al., Kozaki, T. et al., Sultatos, L.G., Nabeshima, T. et al.

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Disease relevance of Fenitrooxone

Although male rat livers produced more chlorpyrifos oxon and fenitrooxon from chlorpyrifos and fenitrothion, respectively, than did livers from female rats, the acute toxicities of chlorpyrifos and fenitrothion were greater in females than in males [1].

High impact information on Fenitrooxone

The cDNA sequences were compared between an insecticide-susceptible strain and the resistant strain, TYM, that exhibits a 870-fold decrease in fenitroxon-sensitivity of AChE [2].
The isolation of desmethyl forms of fenitrooxon and fenitrothion as well as 3-methyl-4-nitrophenol indicates that hydrolysis of both the P-O-aryl and P-O-alkyl bonds occurred [3].
Higher levels of fenitrooxon and lower levels of desmethyl fenitrothion were detected in the 34 ppt seawater than in the 17 ppt seawater [3].
The cDNA of AChE in the housefly, Musca domestica, was sequenced and individual flies were genotyped by this gene in an inhibition assay of AChE activity with an organophaspate, fenitroxon [4].
Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point mutations [4].

References

Metabolic activation of the organophosphorus insecticides chlorpyrifos and fenitrothion by perfused rat liver. Sultatos, L.G. Toxicology (1991) [Pubmed]
An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Japanese encephalitis vector mosquito, Culex tritaeniorhynchus. Nabeshima, T., Mori, A., Kozaki, T., Iwata, Y., Hidoh, O., Harada, S., Kasai, S., Severson, D.W., Kono, Y., Tomita, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
The uptake and in vivo metabolism of the organophosphate insecticide fenitrothion by the blue crab, Callinectes sapidus. Johnston, J.J., Corbett, M.D. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point mutations. Kozaki, T., Shono, T., Tomita, T., Kono, Y. Insect Biochem. Mol. Biol. (2001) [Pubmed]

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