Disease relevance of NSC69190

• Furthermore, the chemotactic behavior of Ralstonia sp. SJ98 towards 3-methyl-4-nitrophenol was tested using three different methods i.e., drop assay, swarm plate assay and capillary assay, which were found to be positive towards this compound [1].
• Fasciculation and muscular weakness were noted, while plasma and urinary 4-nitro-3-methylphenol (NMC), the degradation product of Sumithion, reached a maximum [2].
• The chemicals fenitrothion, nitroso fenitrothion, amino fenitrothion and 3-methyl-4-nitrophenol were tested for mutagenicity to Salmonella typhimurium strains TA98 and TA100, both in the presence and absence of rat liver S-9 mix [3].

High impact information on NSC69190

• Here, error-prone PCR was used to create variant DntB M22L/L380I, which accepts the two new substrates 4-nitrophenol (4NP) and 3-methyl-4-nitrophenol (3M4NP) [4].
• Our efforts here were focused on the in vitro and in vivo anti-androgenic activity of 3-methyl-4-nitrophenol (4-nitro-m-cresol; PNMC), known a degradation product of the insecticide fenitrothion, in diesel exhaust particles [5].
• Being the non-polar methylated aromatic compound, 3-methyl-4-nitrophenol is highly toxic and, therefore, a complete degradation of this compound is important for environmental decontamination/bioremediation purposes [1].
• 1. The metabolic pathways of p-nitroanisole, 4-nitro-m-cresol and methyl parathion in Malaysian prawns (Macrobrachium rosenbergii), ridgeback prawns (Sicyonia ingentis) and crayfish (Procambarus clarkii) were compared [6].
• 3-methyl-4-nitrophenol caused dilatation of rat thoracic artery, and the other two nitrophenols, also showed vasodilatation activities [7].

Biological context of NSC69190

• The mutagenic effect of 3-methyl-4-nitro-phenol on the germ-cells of CFLP male mice was studied by examining the chromosomes of spermatocytes according to the methods of Evans et al. and Schleiermacher in the diakinetic phase of meiosis [8].

Anatomical context of NSC69190

• Mutagenic effect of 3-methyl-4-nitro-phenol on the germ-cells of the mouse--a study in vivo [8].

Analytical, diagnostic and therapeutic context of NSC69190

• From 1995 to 1998 the concentrations of 4-nitrophenol, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenol, dinitro-ortho-cresol (DNOC) and 2,4-di-nitrophenol were measured monthly by HPLC in precipitation at eight different locations in Bavaria (Germany) [9].

References