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Chemical Compound Review

AG-E-77369     4-aminocarbonylbutanoic acid

Synonyms: ALBB-003883, CHEBI:24326, KB-41635, KB-97765, CTK4F5504, ...
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High impact information on Glutaramic acid


Anatomical context of Glutaramic acid

  • Three glutaramic acid derivatives provided with a potent antagonistic activity on the contractions elicited by the carboxyl terminal octapeptide CCK-8 in the guinea pig gallbladder have been evaluated for their capacity to inhibit the binding of [125I]-(Bolton-Hunter)-CCK-8 to both central and peripheric cholecystokinin (CCK) receptors [5].

Associations of Glutaramic acid with other chemical compounds

  • The effects of a new glutaramic acid derivative, 3,4-dichloro-benzamido-N, N-dipentyl-glutaramic acid (CR-1409), on cholecystokinin-stimulated amylase release and 125I-cholecystokinin octapeptide binding were studied in isolated rat pancreatic acini [6].
  • In conscious rats, protein output and the volume of pancreatic juice were significantly decreased for about 2 h in response to 150 mg/kg of proglumide or 3 mg/kg of CR-1392 administered s.c. during diversion of pancreatic juice, demonstrating inhibition of endogenous CCK by glutaramic acid derivatives [7].

Gene context of Glutaramic acid


  1. Release of acetylcholine mediated by cholecystokinin receptor from the guinea pig sphincter of Oddi. Harada, T., Katsuragi, T., Furukawa, T. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  2. Electrophysiological studies on the specificity of the cholecystokinin antagonist proglumide. Chiodo, L.A., Freeman, A.S., Bunney, B.S. Brain Res. (1987) [Pubmed]
  3. The effect of CR 1409, a potent CCK receptor antagonist, on basal and stimulated pancreatic secretion in rat. Takács, T., Nagy, I., Pap, A., Varró, V. Pancreas (1990) [Pubmed]
  4. Effect of proglumide on rat pancreatic growth. Yamaguchi, T., Tabata, K., Johnson, L.R. Am. J. Physiol. (1985) [Pubmed]
  5. Differentiation of central and peripheral cholecystokinin receptors by new glutaramic acid derivatives with cholecystokinin-antagonistic activity. Makovec, F., Bani, M., Chisté, R., Revel, L., Rovati, L.C., Rovati, L.A. Arzneimittel-Forschung. (1986) [Pubmed]
  6. CR-1409: a potent inhibitor of cholecystokinin-stimulated amylase release and cholecystokinin binding in rat pancreatic acini. Iwamoto, Y., Yamamoto, R., Kuzuya, T. Pancreas (1987) [Pubmed]
  7. The anti-CCK effect of glutaramic acid derivatives in anesthetized and conscious rats. Takács, T., Nagy, I., Pap, A., Varró, V. Pancreas (1988) [Pubmed]
  8. Different peripheral and central antagonistic activity of new glutaramic acid derivatives on satiety induced by cholecystokinin in rats. Makovec, F., Bani, M., Chistè, R., Revel, L., Rovati, L.C., Setnikar, I. Regul. Pept. (1986) [Pubmed]
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