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MeSH Review

Pancreatic Juice

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Disease relevance of Pancreatic Juice


High impact information on Pancreatic Juice


Chemical compound and disease context of Pancreatic Juice


Biological context of Pancreatic Juice


Anatomical context of Pancreatic Juice


Associations of Pancreatic Juice with chemical compounds

  • These results indicate that cholinergic nerves play no important role in feedback regulation of cholecystokinin release and that the previously reported suppressive effect of atropine on the pancreatic response to diversion of bile and pancreatic juice from the intestine was secondary to inhibition of gastric secretion [23].
  • Effect of pancreatic juice and trypsin on oleic acid-stimulated pancreatic secretion and plasma secretin in dogs [24].
  • Bicarbonate and cyclic AMP content of pure human pancreatic juice in response to graded doses of synthetic secretin [25].
  • Letter: Cyclic GMP in pure human pancreatic juice [26].
  • Our data demonstrate that the major citrate-soluble protein of precipitates in pancreatic juice is identical with "stone protein". They are strongly support the concept that this protein is the organic matrix of pancreatic stones [27].

Gene context of Pancreatic Juice

  • Telomerase detection in cells derived from breast fine needle aspirates, bronchial washes, and pancreatic juices show high sensitivity and specificity for cancer detection [28].
  • In pancreatic juice specimens, some carcinoma samples showed remarkably high expression of hTERT [29].
  • In pancreatic juice, there was a significant difference in S100A6 expression between patients with carcinoma and those with nonneoplastic disease [30].
  • Our findings suggest that the expression of CTSE is associated with the pathogenesis of pancreatic ductal adenocarcinoma, that CTSE in the pancreatic juice seems to be a useful marker for a definitive diagnosis and that CTSE may be expressed at a relatively early stage of multistep carcinogenesis in pancreatic lesions [31].
  • These two proteins were purified to homogeneity from canine pancreatic juice and no significant catalytic activity was observed with dog PLRP1 on any of the substrates tested: di- and tri-glycerides, phospholipids, etc [32].

Analytical, diagnostic and therapeutic context of Pancreatic Juice


  1. Increased cathepsin B activity in pancreatic juice from a patient with pancreatic cancer. Rinderknecht, H., Renner, I.G. N. Engl. J. Med. (1980) [Pubmed]
  2. Pancreatic stone protein. II. Implication in stone formation during the course of chronic calcifying pancreatitis. Multigner, L., Sarles, H., Lombardo, D., De Caro, A. Gastroenterology (1985) [Pubmed]
  3. Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice. Furuya, N., Kawa, S., Akamatsu, T., Furihata, K. Gastroenterology (1997) [Pubmed]
  4. Radioimmunoassay of lactoferrin in pancreatic juice as a test for pancreatic diseases. Fedail, S.S., Harvey, R.F., Salmon, P.R., Read, A.E. Lancet (1978) [Pubmed]
  5. Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Rosty, C., Christa, L., Kuzdzal, S., Baldwin, W.M., Zahurak, M.L., Carnot, F., Chan, D.W., Canto, M., Lillemoe, K.D., Cameron, J.L., Yeo, C.J., Hruban, R.H., Goggins, M. Cancer Res. (2002) [Pubmed]
  6. GP2, the homologue to the renal cast protein uromodulin, is a major component of intraductal plugs in chronic pancreatitis. Freedman, S.D., Sakamoto, K., Venu, R.P. J. Clin. Invest. (1993) [Pubmed]
  7. Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis. Giorgi, D., Bernard, J.P., Rouquier, S., Iovanna, J., Sarles, H., Dagorn, J.C. J. Clin. Invest. (1989) [Pubmed]
  8. Potentiation of cholecystokinin-induced exocrine secretion by both exogenous and endogenous insulin in isolated and perfused rat pancreata. Saito, A., Williams, J.A., Kanno, T. J. Clin. Invest. (1980) [Pubmed]
  9. Metabolism of the pancreatic carcinogen N-nitroso-bis(2-oxopropyl)amine after oral and intraperitoneal administration to Syrian golden hamsters. Gingell, R., Pour, P. J. Natl. Cancer Inst. (1978) [Pubmed]
  10. Importance of endogenous prostaglandins for the toxicity of cyclosporin A to rat endocrine and exocrine pancreas? Rünzi, M., Peskar, B.M., von Schönfeld, J., Müller, M.K. Gut (1992) [Pubmed]
  11. Cyclic-AMP and pancreatic bicarbonate secretion in response to secretin in dogs. Domschke, S., Konturek, S.J., Domschke, W., Dembiński, A., Thor, P., Król, R., Demling, L. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
  12. Autolysis of proproteinase E in bovine procarboxypeptidase A ternary complex gives rise to subunit III. Pascual, R., Vendrell, J., Avilés, F.X., Bonicel, J., Wicker, C., Puigserver, A. FEBS Lett. (1990) [Pubmed]
  13. Development of acute pancreatitis in rats after single ethanol administration and induction of a pancreatic juice edema. Siech, M., Heinrich, P., Letko, G. Int. J. Pancreatol. (1991) [Pubmed]
  14. Ciprofloxacin penetration in pancreatic juice. Pederzoli, P., Falconi, M., Bassi, C., Vesentini, S., Orcalli, F., Scaglione, F., Solbiati, M., Messori, A., Martini, N. Chemotherapy. (1987) [Pubmed]
  15. Fate of radioactive exocrine pancreatic proteins injected into the blood circulation of the rat. Tissue uptake and transepithelial excretion. Rohr, G., Scheele, G. Gastroenterology (1983) [Pubmed]
  16. Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells. Chang, T.M., Chang, C.H., Wagner, D.R., Chey, W.Y. J. Biol. Chem. (1999) [Pubmed]
  17. Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues. Matsubayashi, H., Sato, N., Fukushima, N., Yeo, C.J., Walter, K.M., Brune, K., Sahin, F., Hruban, R.H., Goggins, M. Clin. Cancer Res. (2003) [Pubmed]
  18. Diagnosis of pancreatic adenocarcinoma by detection of human telomerase reverse transcriptase messenger RNA in pancreatic juice with sample qualification. Seki, K., Suda, T., Aoyagi, Y., Sugawara, S., Natsui, M., Motoyama, H., Shirai, Y., Sekine, T., Kawai, H., Mita, Y., Waguri, N., Kuroiwa, T., Igarashi, M., Asakura, H. Clin. Cancer Res. (2001) [Pubmed]
  19. Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice. Uehara, H., Nakaizumi, A., Baba, M., Iishi, H., Tatsuta, M., Kitamura, T., Ohigashi, H., Ishikawa, O., Takenaka, A., Ishiguro, S. Am. J. Gastroenterol. (1996) [Pubmed]
  20. Effect of pancreatic juice diversion on secretin release in rats. Sun, G., Lee, K.Y., Chang, T.M., Chey, W.Y. Gastroenterology (1989) [Pubmed]
  21. The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test meals. Carrière, F., Renou, C., Lopez, V., De Caro, J., Ferrato, F., Lengsfeld, H., De Caro, A., Laugier, R., Verger, R. Gastroenterology (2000) [Pubmed]
  22. Effect of luminal growth factor preservation on intestinal growth. Playford, R.J., Woodman, A.C., Clark, P., Watanapa, P., Vesey, D., Deprez, P.H., Williamson, R.C., Calam, J. Lancet (1993) [Pubmed]
  23. Lack of cholinergic control in feedback regulation of pancreatic secretion in the rat. Guan, D., Ohta, H., Tawil, T., Spannagel, A.W., Liddle, R.A., Green, G.M. Gastroenterology (1990) [Pubmed]
  24. Effect of pancreatic juice and trypsin on oleic acid-stimulated pancreatic secretion and plasma secretin in dogs. Shiratori, K., Jo, Y.H., Lee, K.Y., Chang, T.M., Chey, W.Y. Gastroenterology (1989) [Pubmed]
  25. Bicarbonate and cyclic AMP content of pure human pancreatic juice in response to graded doses of synthetic secretin. Domschke, S., Domschke, W., Rösch, W., Konturek, S.J., Wünsch, E., Demling, L. Gastroenterology (1976) [Pubmed]
  26. Letter: Cyclic GMP in pure human pancreatic juice. Domschke, S., Sprugel, W., Mitznegg, P., Domschke, W. Gastroenterology (1976) [Pubmed]
  27. Protein content of precipitates present in pancreatic juice of alcoholic subjects and patients with chronic calcifying pancreatitis. Guy, O., Robles-Diaz, G., Adrich, Z., Sahel, J., Sarles, H. Gastroenterology (1983) [Pubmed]
  28. Clinical utility of telomerase in cancer. Hiyama, E., Hiyama, K. Oncogene (2002) [Pubmed]
  29. Quantitative assessment of telomerase activity and human telomerase reverse transcriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer. Ohuchida, K., Mizumoto, K., Ogura, Y., Ishikawa, N., Nagai, E., Yamaguchi, K., Tanaka, M. Clin. Cancer Res. (2005) [Pubmed]
  30. The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target. Ohuchida, K., Mizumoto, K., Ishikawa, N., Fujii, K., Konomi, H., Nagai, E., Yamaguchi, K., Tsuneyoshi, M., Tanaka, M. Clin. Cancer Res. (2005) [Pubmed]
  31. Expression of cathepsin E in pancreas: a possible tumor marker for pancreas, a preliminary report. Azuma, T., Hirai, M., Ito, S., Yamamoto, K., Taggart, R.T., Matsuba, T., Yasukawa, K., Uno, K., Hayakumo, T., Nakajima, M. Int. J. Cancer (1996) [Pubmed]
  32. Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations. Roussel, A., de Caro, J., Bezzine, S., Gastinel, L., de Caro, A., Carrière, F., Leydier, S., Verger, R., Cambillau, C. Proteins (1998) [Pubmed]
  33. Purification and immunological characterization of human pancreatic ribonuclease. Kurihara, M., Ogawa, M., Ohta, T., Kurokawa, E., Kitahara, T., Kosaki, G., Watanabe, T., Wada, H. Cancer Res. (1982) [Pubmed]
  34. High proportion of mutant K-ras gene in pancreatic juice of patients with pancreatic cystic lesions. Tateishi, K., Tada, M., Yamagata, M., Isayama, H., Komatsu, Y., Kawabe, T., Shiratori, Y., Omata, M. Gut (1999) [Pubmed]
  35. Serum and pancreatic juice carcinoembryonic antigen in pancreatic and biliary disease. Carr-Locke, D.L. Gut (1980) [Pubmed]
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