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Gene Review

Gast  -  gastrin

Rattus norvegicus

Synonyms: Gas, Gastrin, PPG34
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Disease relevance of Gast


Psychiatry related information on Gast


High impact information on Gast


Chemical compound and disease context of Gast


Biological context of Gast


Anatomical context of Gast

  • Bombesin dose-dependently increased gastrin secretion; this stimulatory effect on the G cell was significantly reduced after a 72-h starvation [6].
  • BACKGROUND & AIMS: In gastric antrum, somatostatin exerts a tonic inhibitory influence on gastrin and histamine secretion [22].
  • Gastrin is trophic for the normal gastric oxyntic mucosa and exerts a growth-promoting action on gastrointestinal malignancy [1].
  • Thus, pancreatic gastrin gene expression shows a reciprocal relationship to the developmental expression of cholecystokinin in the duodenum [18].
  • SOS, either alone or co-administered with epinephrine or gastrin heptadecapeptide (G17), dose-dependently stimulated SLI release by isolated canine fundic D-cells [23].

Associations of Gast with chemical compounds

  • The aim of this study was to identify the sst subtype regulating gastrin and histamine secretion in human, dog, and rat stomach [22].
  • The rate of gastrin release stimulated by carbachol was suppressed significantly by each dose of somatostatin examined (10(-8) M to 10(-4) M) [24].
  • Basal and acetylcholine-stimulated gastrin release were significantly lower after a 3 day starvation, whereas the inhibitory effect of acetylcholine and the stimulatory effect of glucagon on somatostatin secretion were not influenced by fasting [6].
  • Feeding did not change the sulfation of amidated heptadecapeptide gastrin or its glycine-extended variant [19].
  • The post-translational processing of the pancreatic gastrin peptide, however, differs in being fully tyrosine sulfated, and thus it resembles gastrin's homologue, cholecystokinin [18].

Physical interactions of Gast

  • These data suggest a SS receptor/G protein uncoupling as a result of binding of pentagastrin to gastrin receptors present in pancreatic acinar cell membranes [25].
  • These new compounds bear a histamine H2 receptor antagonist (H2A) pharmacophore moiety attached to a gastrin receptor antagonist (GA) pharmacophore moiety in a reversed manner, namely the head-to-head manner, different from the previously reported head-to-tail manner [26].

Regulatory relationships of Gast


Other interactions of Gast


Analytical, diagnostic and therapeutic context of Gast


  1. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. Guo, Y.S., Cheng, J.Z., Jin, G.F., Gutkind, J.S., Hellmich, M.R., Townsend, C.M. J. Biol. Chem. (2002) [Pubmed]
  2. Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on the inhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells. Hofland, L.J., van Koetsveld, P.M., Waaijers, M., Zuyderwijk, J., Lamberts, S.W. Endocrinology (1994) [Pubmed]
  3. Intracellular mechanisms mediating the anti-apoptotic action of gastrin. Ramamoorthy, S., Stepan, V., Todisco, A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  4. Hypogastrinemia in streptozotocin diabetes with islet transplantation--reconstitution. Fabri, P.J., Weber, C.J., Gower, W.R., Reemtsma, K. J. Surg. Res. (1983) [Pubmed]
  5. Effect of high temperature on gastrin, somatostatin and motilin production in ulcerous gastric antral mucosa of rats. Sun, F.P., Dan, H.L., Song, Y.G., Cheng, W. Di Yi Jun Yi Da Xue Xue Bao (2002) [Pubmed]
  6. Effect of food deprivation on rat gastric somatostatin and gastrin release. Koop, H., Schwab, E., Arnold, R., Creutzfeldt, W. Gastroenterology (1982) [Pubmed]
  7. Partial sleep deprivation compromises gastric mucosal integrity in rats. Guo, J.S., Chau, J.F., Cho, C.H., Koo, M.W. Life Sci. (2005) [Pubmed]
  8. Physiological role of cholecystokinin B/gastrin receptor in leptin secretion. Attoub, S., Levasseur, S., Buyse, M., Goïot, H., Laigneau, J.P., Moizo, L., Hervatin, F., Le Marchand-Brustel, Y., Lewin, J.M., Bado, A. Endocrinology (1999) [Pubmed]
  9. Serum gastrin increases with increasing dietary calcium but not with increasing dietary fat or fiber in Fischer-344 rats. Floor, M.K., Jahangeer, S., D'Ambrosio, C., Alabaster, O. J. Nutr. (1991) [Pubmed]
  10. Histamine in stress ulcer prophylaxis in rats. Warzecha, Z., Dembiński, A., Brzozowski, T., Ceranowicz, P., Dembiński, M., Stachura, J., Konturek, S.J. J. Physiol. Pharmacol. (2001) [Pubmed]
  11. Complete tyrosine-O-sulphation of gastrin in neonatal rat pancreas. Brand, S.J., Andersen, B.N., Rehfeld, J.F. Nature (1984) [Pubmed]
  12. GABA affects the release of gastrin and somatostatin from rat antral mucosa. Harty, R.F., Franklin, P.A. Nature (1983) [Pubmed]
  13. Localization of targets for anti-ulcer drugs in cells of the immune system. Mezey, E., Palkovits, M. Science (1992) [Pubmed]
  14. Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. Brand, S.J., Stone, D. J. Clin. Invest. (1988) [Pubmed]
  15. Peptide YY inhibition of rat gastric enterochromaffin-like cell function. Zeng, N., Walsh, J.H., Kang, T., Wu, S.V., Sachs, G. Gastroenterology (1997) [Pubmed]
  16. Helicobacter pylori lipopolysaccharide stimulates histamine release and DNA synthesis in rat enterochromaffin-like cells. Kidd, M., Miu, K., Tang, L.H., Perez-Perez, G.I., Blaser, M.J., Sandor, A., Modlin, I.M. Gastroenterology (1997) [Pubmed]
  17. Influence of chronic drug-induced achlorhydria by substituted benzimidazoles on the endocrine stomach in rats. Koop, H., Willemer, S., Steinbach, F., Eissele, R., Tuch, K., Arnold, R. Gastroenterology (1987) [Pubmed]
  18. Differential gastrin gene expression in rat gastrointestinal tract and pancreas during neonatal development. Brand, S.J., Fuller, P.J. J. Biol. Chem. (1988) [Pubmed]
  19. Processing of the gastrin precursor. Modulation of phosphorylated, sulfated, and amidated products. Varro, A., Nemeth, J., Bridson, J., Lee, C., Moore, S., Dockray, G.J. J. Biol. Chem. (1990) [Pubmed]
  20. Molecular cloning and sequencing of a rat preprogastrin complementary deoxyribonucleic acid. Fuller, P.J., Stone, D.L., Brand, S.J. Mol. Endocrinol. (1987) [Pubmed]
  21. Intracellular signal transduction during gastrin-induced histamine secretion in rat gastric ECL cells. Zanner, R., Hapfelmeier, G., Gratzl, M., Prinz, C. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  22. Somatostatin receptor subtype 2 mediates inhibition of gastrin and histamine secretion from human, dog, and rat antrum. Zaki, M., Harrington, L., McCuen, R., Coy, D.H., Arimura, A., Schubert, M.L. Gastroenterology (1996) [Pubmed]
  23. Sucrose octasulfate stimulates gastric somatostatin release. Lucey, M.R., Park, J., DelValle, J., Wang, L.D., Yamada, T. Am. J. Med. (1991) [Pubmed]
  24. Somatostatin inhibition of basal and carbachol-stimulated gastrin release in rat antral organ culture. Harty, R.F., Maico, D.G., McGuigan, J.E. Gastroenterology (1981) [Pubmed]
  25. The effect of pentagastrin on the somatostatin receptor/effector system in rat pancreatic acinar membranes. Alvaro-Alonso, I., Muñoz-Acedo, G., Arilla, E. Regul. Pept. (1994) [Pubmed]
  26. Synthesis and biological evaluation of a new reversely linked type of dual histamine H2 and gastrin receptor antagonist. Kawanishi, Y., Ishihara, S., Takahashi, K., Tsushima, T., Hagishita, S., Ishikawa, M., Ishihara, Y. Chem. Pharm. Bull. (1997) [Pubmed]
  27. Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin. Ferrand, A., Kowalski-Chauvel, A., Bertrand, C., Pradayrol, L., Fourmy, D., Dufresne, M., Seva, C. Exp. Cell Res. (2004) [Pubmed]
  28. Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats. Komori, M., Tsuji, S., Sun, W.H., Tsujii, M., Kawai, N., Yasumaru, M., Kakiuchi, Y., Kimura, A., Sasaki, Y., Higashiyama, S., Kawano, S., Hori, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  29. Molecular mechanisms for the antiapoptotic action of gastrin. Todisco, A., Ramamoorthy, S., Witham, T., Pausawasdi, N., Srinivasan, S., Dickinson, C.J., Askari, F.K., Krametter, D. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  30. Role of neuropeptide-sensitive L-type Ca(2+) channels in histamine release in gastric enterochromaffin-like cells. Zeng, N., Athmann, C., Kang, T., Walsh, J.H., Sachs, G. Am. J. Physiol. (1999) [Pubmed]
  31. Somatostatin, misoprostol and galanin inhibit gastrin- and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca2+ channels. Björkqvist, M., Bernsand, M., Eliasson, L., Håkanson, R., Lindström, E. Regul. Pept. (2005) [Pubmed]
  32. Evaluation of the effects of pentagastrin, gastrin and pancreatic glucagon on cell proliferation in the rat gastrointestinal tract. Fatemi, S.H., Cullan, G.E., Sharp, J.G. Cell and tissue kinetics. (1984) [Pubmed]
  33. Topography of somatostatin cells in the stomach of the rat: possible functional significance. Alumets, J., Ekelund, M., El Munshid, H.A., Håkanson, R., Lorén, I., Sundler, F. Cell Tissue Res. (1979) [Pubmed]
  34. Gastric inhibitory polypeptide and glucagon-like peptide-1(7-36) amide exert similar effects on somatostatin secretion but opposite effects on gastrin secretion from the rat stomach. Jia, X., Brown, J.C., Kwok, Y.N., Pederson, R.A., McIntosh, C.H. Can. J. Physiol. Pharmacol. (1994) [Pubmed]
  35. Mucus, gastrin and somatostatin cells in cultured rat antral mucosa: immunofluorescence, ultrastructural and radioimmunological studies. Sahondramanarivo, G., Hollande, E., Pequignot, J., Accary, J.P., Dubrasquet, J.M. Gastroenterol. Clin. Biol. (1986) [Pubmed]
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