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Chemical Compound Review:

AG-E-10627 3-chloroprop-2-enoic acid

Synonyms: AG-G-29794, ACMC-20ajga, ACMC-20alf8, CTK4D0688, CTK5B5260, ...

Poelarends, G.J. et al., de Jong, R.M. et al., Azurmendi, H.F. et al., Poelarends, G.J. et al., van Hylckama Vlieg, J.E. et al.

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Disease relevance of C06615

The genes (caaD1 and caaD2) encoding the trans-3-chloroacrylic acid dehalogenase (CaaD) of the 1,3-dichloropropene-utilizing bacterium Pseudomonas pavonaceae 170 were cloned and heterologously expressed in Escherichia coli and Pseudomonas sp. strain GJ1 [1].

High impact information on C06615

Crystal Structures of Native and Inactivated cis-3-Chloroacrylic Acid Dehalogenase: STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY AND INACTIVATION BY (R)-OXIRANE-2-CARBOXYLATE [2].
Stereospecific alkylation of cis-3-chloroacrylic acid dehalogenase by (R)-oxirane-2-carboxylate: analysis and mechanistic implications [3].
The roles of active-site residues in the catalytic mechanism of trans-3-chloroacrylic acid dehalogenase: a kinetic, NMR, and mutational analysis [4].
trans-3-Chloroacrylic acid dehalogenase from Pseudomonas pavonaceae 170 shares structural and mechanistic similarities with 4-oxalocrotonate tautomerase [1].
The cis-3-chloroacrylic acid dehalogenase consisted of two polypeptide chains of a molecular weight 16.2 kDa [5].

References

trans-3-Chloroacrylic acid dehalogenase from Pseudomonas pavonaceae 170 shares structural and mechanistic similarities with 4-oxalocrotonate tautomerase. Poelarends, G.J., Saunier, R., Janssen, D.B. J. Bacteriol. (2001) [Pubmed]
Crystal Structures of Native and Inactivated cis-3-Chloroacrylic Acid Dehalogenase: STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY AND INACTIVATION BY (R)-OXIRANE-2-CARBOXYLATE. de Jong, R.M., Bazzacco, P., Poelarends, G.J., Johnson, W.H., Kim, Y.J., Burks, E.A., Serrano, H., Thunnissen, A.M., Whitman, C.P., Dijkstra, B.W. J. Biol. Chem. (2007) [Pubmed]
Stereospecific alkylation of cis-3-chloroacrylic acid dehalogenase by (R)-oxirane-2-carboxylate: analysis and mechanistic implications. Poelarends, G.J., Serrano, H., Johnson, W.H., Whitman, C.P. Biochemistry (2004) [Pubmed]
The roles of active-site residues in the catalytic mechanism of trans-3-chloroacrylic acid dehalogenase: a kinetic, NMR, and mutational analysis. Azurmendi, H.F., Wang, S.C., Massiah, M.A., Poelarends, G.J., Whitman, C.P., Mildvan, A.S. Biochemistry (2004) [Pubmed]
Bacterial degradation of 3-chloroacrylic acid and the characterization of cis- and trans-specific dehalogenases. van Hylckama Vlieg, J.E., Janssen, D.B. Biodegradation (1991) [Pubmed]

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