Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-K-62551 2- ethanimidoyloxyethanesulfonic acid

Synonyms: CTK5D2076, AR-1D5405, AC1L4Y27, AC1Q6X9Z, A843592, ...

Harbin, B.M. et al., Nemes, P.P. et al., Crain, R.C. et al., Davis, T.N. et al.

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Disease relevance of Isethionyl acetimidate

All of the phage proteins reacted with both EAI and IAI (except a DNA-associated protein which reacted only with EAI) [1].

High impact information on Isethionyl acetimidate

Data obtained with the membrane-impermeable amino reagent isethionyl acetimidate indicate that ferrochelatase physically spans the inner mitochondrial membrane with portions of the protein exposed on both sides of the membrane [2].
The permeabilities of both this compound and the "impermeable" reagent isethionyl acetimidate (IAI) across the rod outer segment disk membrane were directly measured [3].
The reaction of methyl acetimidate or isethionyl acetimidate with mitoplasts at pH 8.5 yields two derivatives of phosphatidylethanolamine [4].

References

An alkyl imidate labeling study of the organization of phospholipids and proteins in the lipid-containing bacteriophage PR4. Davis, T.N., Cronan, J.E. J. Biol. Chem. (1985) [Pubmed]
Orientation of ferrochelatase in bovine liver mitochondria. Harbin, B.M., Dailey, H.A. Biochemistry (1985) [Pubmed]
Covalent modification of rhodopsin with imidoesters: evidence for transmembrane arragnement of rhodopsin in rod outer segment disk membranes. Nemes, P.P., Miljanich, G.P., White, D.L., Dratz, E.A. Biochemistry (1980) [Pubmed]
Cross-linking of membrane phospholipid and protein using putative monofunctional imidoesters. Crain, R.C., Marinetti, G.V. Chem. Phys. Lipids (1978) [Pubmed]

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