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Chemical Compound Review:

Mesulfenos dimethoxy-(3-methyl-4- methylsulfinyl...

Synonyms: Mesulfenfos, Fensulfoxide, AC1L2EEV, LS-108855, AKOS015903359, ...

Kitamura, S. et al., Furnes, B. et al.

Kitamura, Suzuki, Kadota, Yoshida, Ohashi, Ohta,

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High impact information on Fensulfoxide

A high level of stereoselectivity in the formation of fenthion +-sulfoxide was observed in kidney and intestinal microsomes [1].
In vitro metabolism of fenthion and fenthion sulfoxide by liver preparations of sea bream, goldfish, and rats [2].
Thus, fenthion and fenthion sulfoxide are interconvertible in fish and rats through the activities of cytochrome P450, flavin-containing monooxygenase, and aldehyde oxidase [2].
Fenthion was oxidized to fenthion sulfoxide and the oxon derivative, but not to its sulfone, in the presence of NADPH by liver microsomes of sea bream, goldfish, and rats [2].
The in vitro metabolism of fenthion and its sulfoxide (fenthion sulfoxide) in sea bream (Pagrus major) and goldfish (Carassius auratus) was investigated and compared with that in rats [2].

References

Extrahepatic metabolism of carbamate and organophosphate thioether compounds by the flavin-containing monooxygenase and cytochrome P450 systems. Furnes, B., Schlenk, D. Drug Metab. Dispos. (2005) [Pubmed]
In vitro metabolism of fenthion and fenthion sulfoxide by liver preparations of sea bream, goldfish, and rats. Kitamura, S., Suzuki, T., Kadota, T., Yoshida, M., Ohashi, K., Ohta, S. Drug Metab. Dispos. (2003) [Pubmed]

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