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Chemical Compound Review:

Lycurim 1,4-bis(2- methylsulfonyloxyethylamino) buta...

Synonyms: Lykurim, ritosulfan, Ritrosulfan, Ritrosulfano, Ritrosulfanum, ...

Lui, M.S. et al., Kerpel-Fronius, S. et al., Ban, J. et al., Stoychkov, J.N. et al., Stovrovskaya, A.A. et al., et al.

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Disease relevance of Lykurim

When 10 rats with hepatoma 8999 were treated 15 times with the optimal dose of Lycurim (7.5 mg/kg every 10 1/2 days), 1-year survivors numbered 7 [1].
Alternate doses of Lycurim (7.5 mg/kg) and PF (3 mg/kg) at 5-day intervals for 4 months to 10 rats gave an ILS of 152% with eight 1-year survivors and no host toxicity [1].
A dose escalation study was started to determine the applicability of Lycurim in the form of high volume intraperitoneal instillation ('belly bath') for the treatment of ovarian cancer [2].
Evaluation of the therapeutic effect of lycurim in lymphoma [3].
Lycurim (NSC 122402) in the treatment of chronic lymphocytic leukemia [4].

High impact information on Lykurim

The more rapidly growing, less differentiated hepatoma 3924A was tenfold less sensitive to Lycurim in vitro, and three treatments in vivo (10 mg/kg given every 8 days) gave an ILS of only 18% in ACI/N rats [1].
Hepatoma 8999 was sensitive to Lycurim [1,4-di-(methylsulfonyloxy-ethylamino)-1,4-dideoxy-ms-erythritol] with a mean lethal dose (LD50) of 8.1 X 10(-8) M for a 6-hour treatment in vitro [1].
Lycurium [1,4-di-(methylsulfonyloxy-ethylamino)-1,4-didesoxy-erythrioldimethylsulfonate; R-74; NSC-122402] undergoes rapid hydrolysis in aqueous solutions [2].
Lycurim and PF given together in their IC50 concentrations (0.016 and 0.085 microM, respectively) yielded synergistic cell kill in 7-day treatment of proliferating cultures [5].
The authors treated DBA/2 mice with L1210 leukemia with cyclophosphamide (CY) plus lycurim (LY), both alkylating agents [6].

Chemical compound and disease context of Lykurim

Action of lycurim and pyrazofurin on hepatoma 3924A cells in culture [5].

Anatomical context of Lykurim

The chromosome-mutagenic action of Lycurim was also equal on both cell lines [7].

Analytical, diagnostic and therapeutic context of Lykurim

This conclusion is supported by clinical experience showing that intracavitary administration of the same amount of Lycurim causes much milder systemic side-effects than intravenous injection [2].

References

Rat hepatomas: chemotherapy with lycurim and pyrazofurin. Lui, M.S., Jackson, R.C., Harkrader, R.J., Weber, G. J. Natl. Cancer Inst. (1982) [Pubmed]
Chemical reactivity and intracavitary application of alkylating sugar alcohol derivatives. Kerpel-Fronius, S., Csetényi, J., Hegedüs, L., Horváth, I.P., Ringwald, G., Töttössy, B., Eckhardt, S. Oncology (1980) [Pubmed]
Evaluation of the therapeutic effect of lycurim in lymphoma. Kotlarek-Haus, S., Frydecka, I., Gatazka, Z., Gabryś, K. Therapia Hungarica (English edition) (1981) [Pubmed]
Lycurim (NSC 122402) in the treatment of chronic lymphocytic leukemia. Klener, P. Neoplasma (1982) [Pubmed]
Action of lycurim and pyrazofurin on hepatoma 3924A cells in culture. Ban, J., Olah, E., Werber, G. Cancer treatment reports. (1982) [Pubmed]
Combined therapy of L1210 leukemia with cyclophosphamide and lycurim. Stoychkov, J.N., Milushev, A.S., Todorov, D.K. Neoplasma (1980) [Pubmed]
Cross-resistance of transformed mouse cells to some drugs. Stovrovskaya, A.A., Stromskaya, T.P., Serpinskaya, A.S., Kaszás, I., Schuler, D., Pogosianz, n.u.l.l. Acta biologica Academiae Scientiarum Hungaricae. (1976) [Pubmed]

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