Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Hylene W 1-isocyanato-4-[(4- isocyanatocyclohexyl)me...

Synonyms: Nacconate H 12, CHEBI:53216, HSDB 7189, LS-84454, AKOS000120188, ...

Stadler, J. et al., Dearman, R.J. et al., Karol, M.H. et al., Weyel, D.A. et al., Frick, M. et al., et al.

Frick, Björkner, Hamnerius, Zimerson,

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Disease relevance of Hylene W

The use of two animal models to examine factors affecting the production of delayed hypersensitivity to dicyclohexylmethane-4,4'-diisocyanate (HMDI) is described [1].
Allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate [2].
Contact sensitivity to hylene W [3].

High impact information on Hylene W

In the present study we have examined immune responses in mice following topical exposure to three allergenic diisocyanates; diphenylmethane-4,4'-diisocyanate (MDI), dicyclohexylmethane-4,4'-diisocyanate (HMDI), and isophorone diisocyanate (IPDI) [4].
Extensive skin sensitization with minimal antibody production in guinea pigs as a result of exposure to dicyclohexylmethane-4,4'-diisocyanate [5].

Biological context of Hylene W

Experimental delayed hypersensitivity following inhalation of dicyclohexylmethane-4,4'-diisocyanate: a concentration-response relationship [1].

Gene context of Hylene W

Two such isocyanates are diphenylmethane-4,4'-diisocyanate (MDI) and dicyclohexylmethane-4,4'-diisocyanate (SMDI) [6].

References

Experimental delayed hypersensitivity following inhalation of dicyclohexylmethane-4,4'-diisocyanate: a concentration-response relationship. Stadler, J., Karol, M.H. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
Allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate. Frick, M., Björkner, B., Hamnerius, N., Zimerson, E. Contact Derm. (2003) [Pubmed]
Contact sensitivity to hylene W. King, C.M. Contact Derm. (1980) [Pubmed]
Characterization of murine immune responses to allergenic diisocyanates. Dearman, R.J., Spence, L.M., Kimber, I. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
Extensive skin sensitization with minimal antibody production in guinea pigs as a result of exposure to dicyclohexylmethane-4,4'-diisocyanate. Karol, M.H., Magreni, C. Toxicol. Appl. Pharmacol. (1982) [Pubmed]
Pulmonary and sensory irritation of diphenylmethane-4,4'- and dicyclohexylmethane-4,4'-diisocyanate. Weyel, D.A., Schaffer, R.B. Toxicol. Appl. Pharmacol. (1985) [Pubmed]

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