Disease relevance of 26602-93-7

• In conclusion, the dermal hypersensitivity of guinea pigs to some polyisocyanates was similar to those of their corresponding monomers except for IPDI isocyanurate, suggesting that the results from diisocyanate monomers could not be a valuable approach for the detection of the sensitization potency of the corresponding prepolymers [1].
• Contact hypersensitivity response to isophorone diisocyanate in mice [2].
• Other allergens not found on standard series that can account for shoe dermatitis include isophorone diisocyanate, dimethylaminoethyl ether, and mixed dialkyl thioureas [3].

High impact information on 26602-93-7

• In contrast, under conditions where both caused lymph node cell proliferation and contact sensitization, neither HMDI nor IPDI induced a measurable antibody response of any class [4].
• Total serum IgE content was determined after dermal exposure to various concentrations of isophorone diisocyanate (IPDI), diphenylmethane-4,4'-diisocyanate (MDI), toluene diisocyanate (TDI), 2,4-dinitrochlorobenzene (DNCB), trimellitic anhydride (TMA), formaldehyde (FA), and glutaric dialdehyde (GA) [5].

Associations of 26602-93-7 with other chemical compounds

• Mice treated with TMA, IPDI, MDI, and TDI had statistically (p < 0.01) higher concentrations of serum IgE antibodies than control animals [5].

Analytical, diagnostic and therapeutic context of 26602-93-7

• A method of test for residual isophorone diisocyanate trimer in new polyester-polyurethane coatings on light metal packaging using liquid chromatography with tandem mass spectrometric detection [6].

References