Disease relevance of TI 435

• Clothianidin showed moderate to high toxicity in bioassays, depending on the C. pomonella stage tested, but poor fruit protection from attack in field trials [1].

High impact information on TI 435

• Here, we have used whole-cell patch-clamp recording of cholinergic neurons cultured from the central nervous system of 3rd instar Drosophila larvae to examine the actions of acetylcholine (ACh) and nicotine, as well as the neonicotinoids imidacloprid, clothianidin and P-CH-clothianidin on native nAChRs of these neurons [2].
• Absorption, tissue distribution, excretion, and metabolism of clothianidin in rats [3].
• The maximum response of the SAD beta 2 nicotinic receptor to clothianidin was larger than that observed for acetylcholine [4].
• In field trials where insecticides were applied preventively against eggs and young larvae, the molt-accelerating compound halofenozide and the neonicotinoids imidacloprid and thiamethoxam were ineffective, whereas another neonicotinoid, clothianidin, provided 62-93% control [5].

Anatomical context of TI 435

• Super agonist actions of clothianidin and related compounds on the SAD beta 2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes [4].

References