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Chemical Compound Review

Dihydrochrysin     5,7-dihydroxy-2-phenyl- chroman-4-one

Synonyms: SureCN291899, AG-G-65646, NSC-43318, NSC-279005, NSC-661207, ...
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Disease relevance of Pinostrobin


High impact information on Pinostrobin

  • On the basis of the extremely high QR inducing potency of one of these compounds, pinostrobin (5-hydroxy-7-methoxyflavanone), a bioassay-guided search was conducted which revealed a dietary source of pinostrobin, Boesenbergia pandurata (fingerroot), with extraordinarily high ability to induce mammalian phase 2 detoxication enzymes [2].
  • RESULTS: We have shown that 5-hydroxy-7-methoxy flavanone (pinostrobin) isolated from Polygonum lapathifolium ssp. nodosum quickly penetrates through cytoplasm to the cellular nucleus of the cultured cells, and gives intensive apoptotic response in stimulating leukemic cells in vitro [3].
  • The number of apoptotic cells increased with the concentration of pinostrobin: 10 nM - 25% and 60%; 100 nM - 45% and 76%; 1 microm - 70% and 88% for Jurkat and HL60 cell lines, respectively CONCLUSION: Pinostrobin may be considered as a good candidate for a leukemia chemopreventic agent [3].
  • This result showed that pinostrobin inhibited DNA topoisomerase I activity [1].


  1. Cytotoxic mechanism of flavonoid from Temu Kunci (Kaempferia pandurata) in cell culture of human mammary carcinoma. Sukardiman, n.u.l.l., Darwanto, A., Tanjung, M., Darmadi, M.O. Clin. Hemorheol. Microcirc. (2000) [Pubmed]
  2. Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes. Fahey, J.W., Stephenson, K.K. J. Agric. Food Chem. (2002) [Pubmed]
  3. Pinostrobin--an anti-leukemic flavonoid from Polygonum lapathifolium L. ssp. nodosum (Pers.) Dans. Smolarz, H.D., Mendyk, E., Bogucka-Kocka, A., Kocki, J. Z. Naturforsch., C, J. Biosci. (2006) [Pubmed]
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