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Chemical Compound Review

Lopac-B-3650     trimethyl-(2-oxoethyl)azanium

Synonyms: AG-K-66397, CHEBI:15710, HMDB01252, bmse000070, CCG-204277, ...
 
 
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High impact information on BTL

  • The purified enzyme showed similar substrate specificities with either choline or betaine-aldehyde as the substrate, as indicated by the apparent V/K values (where V is the maximal velocity and K is the Michaelis constant) of 0.9 and 0.6 micro mol of O(2) min(-1) mg(-1) mM(-1) at pH 7 and 25 degrees C, respectively [1].
  • In the present study, pH and deuterium kinetic isotope effects with [1,2-2H(4)]-choline were used to study the mechanism of oxidation of choline to betaine-aldehyde [2].
  • Betaine, one of the major renal organic osmolytes, is synthesized from choline by choline dehydrogenase (EC 1.1.99.1) and betaine-aldehyde dehydrogenase (EC 1.2.1.8) in the kidney [3].
 

Analytical, diagnostic and therapeutic context of BTL

References

 
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