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Chemical Compound Review:

CEGABA 4-(2- carboxyethylamino)butanoic acid

Synonyms: spermidate, Spermidic acid, C1181_SIGMA, C5556_SIGMA, HMDB02201, ...

Astaldi Ricotti, G.C. et al., Bo, P. et al., Kawase, H. et al.

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Disease relevance of BRN 1774240

It is possible that CEGABA acts on cells other than EBV-transformed lymphocytes (in fact, after EBV infection all types of mononuclear cells from the blood are present in the culture) and indirectly promotes the growth of EBV-transformed lymphocytes [1].
The central effects of carboxyethyl-gamma-aminobutyric acid (CEGABA) have been studied both in rabbits and in the guinea pig myoclonus model [2].

High impact information on BRN 1774240

Acid hydrolysis of the radioactive compound produced radioactive spermidic acid, confirming the identification [3].
CEGABA enhances the growth of hybridomas through all the steps of hybridoma technology and induces the formation of a large number of EBV-transformed lymphocytes, when added to the culture medium immediately after EBV infection [1].
Furthermore the effects of a polyamine derivative, carboxyethyl gamma-aminobutyric acid (CEGABA), were studied on the growth of hybridomas and Epstein-Barr Virus-transformed cell lines [1].

Anatomical context of BRN 1774240

However, CEGABA shows only a moderate effect on the stability of EBV-transformed cell lines over time, and does not effect the growth of stabilized cell lines [1].

References

Synthetic and natural factors promoting production of murine and human monoclonal antibodies. Astaldi Ricotti, G.C., Negri, C., Cerino, A., Bestagno, M., Fussi, F. Ann. Ist. Super. Sanita (1991) [Pubmed]
Experimental study on central effects of carboxyethyl-gamma-aminobutyric acid (CEGABA). Bo, P., Camana, C., Curti, M., Fussi, F., Giorgetti, A., Savoldi, F. Il Farmaco; edizione scientifica. (1988) [Pubmed]
A study on the metabolism of spermidine in mammals: purification and identification of a newly identified metabolite, 2-oxo-1-pyrrolidinepropionic acid, in rat urine. Kawase, H., Hasegawa, T., Hashimoto, H., Noto, T., Nakajima, T. J. Biochem. (1994) [Pubmed]

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