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Chemical Compound Review

Eldepryl     N-methyl-N-[(2R)-1- phenylpropan-2-yl]prop...

Synonyms: Zelapar, Selegyline, selegiline, Emsam, Humex, ...
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Disease relevance of Eldepryl

  • The selective monoamine oxidase (MAO) B inhibitor L-deprenyl (Eldepryl, Jumex, Movergan, Selegiline) has gained acceptance as a useful form of adjunctive therapy in the treatment of Parkinson's disease [1].
  • Due to these properties Jumex may be used for the prevention, moderation of motion sickness, one of the widespread phenomena of our age, without decreasing working capacity [2].

High impact information on Eldepryl


Chemical compound and disease context of Eldepryl


Biological context of Eldepryl


  1. R-(-)-deprenyl as a possible protective agent in Parkinson's disease. Tetrud, J.W., Langston, J.W. J. Neural Transm. Suppl. (1987) [Pubmed]
  2. Prevention of motion sickness with selegilinum hydrochloricum. Bodó, G., Elkán, K., Bencze, G. Therapia Hungarica (English edition) (1989) [Pubmed]
  3. Selegiline is ineffective in a collaborative double-blind, placebo-controlled trial for treatment of amyotrophic lateral sclerosis. Lange, D.J., Murphy, P.L., Diamond, B., Appel, V., Lai, E.C., Younger, D.S., Appel, S.H. Arch. Neurol. (1998) [Pubmed]
  4. Acute asthma precipitated by accidental inhalation of sodium bicarbonate granules (Carbex). Griffith, J., White, P. Clinical radiology. (1994) [Pubmed]
  5. Eldepryl prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral neuronal apoptosis in mice. Guo, M., Chen, S., Liu, Z., Chen, H. Chin. Med. J. (2001) [Pubmed]
  6. Bioavailability of two selegiline hydrochloride tablet products. Müller, F.O., Schall, R., Hundt, H.K., Joubert, A., Middle, M.V., Muir, A.R., Duursema, L., Groenewoud, G., Swart, K.J. Arzneimittel-Forschung. (1996) [Pubmed]
  7. Experience with selegiline and levodopa in advanced Parkinson's disease. Lieberman, A., Fazzini, E. Acta Neurol. Scand., Suppl. (1991) [Pubmed]
  8. Inhalation of Carbex. Mills, J.O. Clinical radiology. (1990) [Pubmed]
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