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MeSH Review

Mice, Inbred C57BL

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Disease relevance of Mice, Inbred C57BL


Psychiatry related information on Mice, Inbred C57BL


High impact information on Mice, Inbred C57BL


Chemical compound and disease context of Mice, Inbred C57BL


Biological context of Mice, Inbred C57BL

  • In C57BL mice milk-borne infection with B-tropic murine leukemia virus (V+ denoting positive for milk-transmitted B-tropic virus and V- denoting negative for milk-transmitted B-tropic virus) was accompanied by an antibody response against viral envelope antigens (VEA) [17].
  • We also isolated the tk gene from a mouse C57BL/10J cosmid library [18].
  • Modified lipoprotein lipase activities, rates of lipogenesis, and lipolysis as factors leading to lipid depletion in C57BL mice bearing the preputial gland tumor, ESR-586 [19].
  • The present study shows that the tumor promotor 12-O-tetradecanoylphorbol 13-acetate (TPA) but not the initiator urethane depletes Ia-positive LC from BALB/c murine ear epidermis, and beta-glucuronidase-positive LC from C57BL mouse tail skin [20].
  • Although C57BL mice were less susceptible to experimental UTI than CBA/J mice, wild-type and p47(phox-/-) C57BL mice were similarly susceptible, and the oxyR mutant of Ec1a was similarly attenuated in C57BL mice, regardless of the p47(phox) genotype, as in CBA/J mice [21].

Anatomical context of Mice, Inbred C57BL


Associations of Mice, Inbred C57BL with chemical compounds

  • Enzyme preparations from rats pretreated with P-448-dependent aryl hydrocarbon hydroxylase inducers [3-methylcholanthrene (MCA) and beta-naphthoflavone] and MCA-treated "responsive" C57BL mice also metabolized quinoline to a mutagen, but phenobarbital and pregnenolone-16alpha-carbonitrile pretreatment did not yield active preparations [27].
  • The migration of tritiated thymidine ([3H]dThd)-labeled cells toward the epithelial surface was recorded at various intervals (from 1 to 240 hr) in the normal and atypical cervical epithelial of 127 C57BL mice [28].
  • Tumor cells incubated with levan showed a pronounced decrease in oncogenic properties when inoculated sc in the syngeneic hosts (C57BL mice), although the viability of cells as determined by the trypan blue exclusion test was not diminished [29].
  • Because these temporal domains are not different between C3H and C57BL mice, the sensitivity windows are set independently of the rhythmic melatonin signal [30].
  • Following i.p. injection of dimethylnitrosamine into male C57BL mice, synthesis of liver nuclear heterogeneous RNA was inhibited significantly, reaching approximately 20% of control within 2 hr of a dose of 40 mg/kg [31].

Gene context of Mice, Inbred C57BL

  • Thus, both IL-10 and IL-4 adversely affect the ability of C57BL mice to resist infection with C. immitis, but IL-10 has a larger effect and is the cytokine that is consistently associated with susceptibility in all strains of inbred mice [32].
  • Male C57BL mice were injected ip with 100 microl saline and 2 or 4 microg/g BW mouse leptin in saline vehicle, and 4 h later they were subjected to 2 h of restraint stress by taping the hind limbs together or no stress [33].
  • Striatal DA terminal density as judged by specific [3H]mazindol binding was not altered while the levels of TH mRNA were elevated in the SN of hph-1 mice compared to control (C57BL) mice [34].
  • By using the yeast two-hybrid system with the N-terminal half of AHR as a probe, which contains the bHLH and PAS regions, to screen cDNA libraries prepared from human lymphocytes and C57BL mouse liver for clones encoding proteins capable of binding to these regions, we isolated a partial ARNT cDNA clone [35].
  • Acute restraint stress also resulted in increased dura mast cell activation in C57BL mice, but not in NK-1R-/- mice [36].

Analytical, diagnostic and therapeutic context of Mice, Inbred C57BL


  1. Kinetics of cell replication of the uterine cervix. V. Behavior of DNA-replicating tumor cells in invasive squamous carcinomas in mice. Rubio, C.A., Kock, Y. J. Natl. Cancer Inst. (1981) [Pubmed]
  2. Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Vile, R.G., Nelson, J.A., Castleden, S., Chong, H., Hart, I.R. Cancer Res. (1994) [Pubmed]
  3. Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography. Frei, J.V., Swenson, D.H., Warren, W., Lawley, P.D. Biochem. J. (1978) [Pubmed]
  4. Genetic evidence for the role of the Lv locus in early susceptibility but not IL-10 synthesis in experimental coccidioidomycosis in C57BL mice. Fierer, J., Walls, L., Kirkland, T.N. J. Infect. Dis. (2000) [Pubmed]
  5. Intramuscular transfer of naked calcitonin gene-related peptide gene prevents autoimmune diabetes induced by multiple low-dose streptozotocin in C57BL mice. Sun, W., Wang, L., Zhang, Z., Chen, M., Wang, X. Eur. J. Immunol. (2003) [Pubmed]
  6. Effects of prenatal ethanol exposure in C57BL mice on locomotor activity and passive avoidance behavior. Becker, H.C., Randall, C.L. Psychopharmacology (Berl.) (1989) [Pubmed]
  7. Dehydration affects synaptic transmission at flexor muscle in acute lead-treated mice. Al Shuaib, W.B., Fahim, M.A., Davidson, N. Cell. Mol. Biol. (Noisy-le-grand) (1999) [Pubmed]
  8. Induction by estrogen metabolite 16 alpha-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. Telang, N.T., Suto, A., Wong, G.Y., Osborne, M.P., Bradlow, H.L. J. Natl. Cancer Inst. (1992) [Pubmed]
  9. Antitumoral activity of indomethacin on experimental esophageal tumors. Rubio, C.A. J. Natl. Cancer Inst. (1984) [Pubmed]
  10. Perinatal metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in C57BL mice. Castonguay, A., Tjälve, H., Trushin, N., Hecht, S.S. J. Natl. Cancer Inst. (1984) [Pubmed]
  11. Species difference in liver microsomal and cytosolic enzymes involved in mutagenic activation of N-hydroxy-N-2-fluorenylacetamide. Kaneda, S., Seno, T., Takeishi, K. J. Natl. Cancer Inst. (1981) [Pubmed]
  12. Activities of organ characteristic enzymes and noradrenaline and glycogen contents in the Albert hepatoma of C57BL mice. Sydow, G. Oncology (1979) [Pubmed]
  13. Evidence for host resistance in 1,3 bis(2-chloroethyl)-1-nitrosourea treatment induced in syngeneic LSA lymphoma. Maruyama, Y., Williams, A., Feola, J.M., Nava, C. J. Cancer Res. Clin. Oncol. (1982) [Pubmed]
  14. Immunotherapy of Lewis lung carcinoma with hydrosoluble peptidoglycan monomer (PGM). Sava, G., Giraldi, T., Tomasić, J., Hrsak, I. Cancer Immunol. Immunother. (1983) [Pubmed]
  15. Antiangiogenic and antitumor effects of tranilast on mouse lung carcinoma cells. Yatsunami, J., Aoki, S., Fukuno, Y., Kikuchi, Y., Kawashima, M., Hayashi, S.I. Int. J. Oncol. (2000) [Pubmed]
  16. Olfactory toxicity resulting from dermal application of 2,6-dichlorobenzonitrile (dichlobenil) in the C57Bl mouse. Deamer, N.J., O'Callaghan, J.P., Genter, M.B. Neurotoxicology (1994) [Pubmed]
  17. Naturally occurring leukemia viruses in H-2 congenic C57BL mice. II. Antibody response to viral envelope antigens. Vlug, A., Melief, C.J., de Bruyne, C., Schoenmakers, H., Molenaar, J.L. J. Natl. Cancer Inst. (1980) [Pubmed]
  18. Molecular cloning and structural analysis of murine thymidine kinase genomic and cDNA sequences. Lin, P.F., Lieberman, H.B., Yeh, D.B., Xu, T., Zhao, S.Y., Ruddle, F.H. Mol. Cell. Biol. (1985) [Pubmed]
  19. Modified lipoprotein lipase activities, rates of lipogenesis, and lipolysis as factors leading to lipid depletion in C57BL mice bearing the preputial gland tumor, ESR-586. Thompson, M.P., Koons, J.E., Tan, E.T., Grigor, M.R. Cancer Res. (1981) [Pubmed]
  20. Suppressor cell activation and enhanced skin allograft survival after tumor promotor but not initiator induced depletion of cutaneous Langerhans cells. Halliday, G.M., Odling, K.A., Ruby, J.C., Muller, H.K. J. Invest. Dermatol. (1988) [Pubmed]
  21. Effect of inactivation of the global oxidative stress regulator oxyR on the colonization ability of Escherichia coli O1:K1:H7 in a mouse model of ascending urinary tract infection. Johnson, J.R., Clabots, C., Rosen, H. Infect. Immun. (2006) [Pubmed]
  22. Behavior of cervical epithelium during carcinogenesis: autoradiography of tritiated cytidine in the C57BL mouse. Rubio, C.A. J. Natl. Cancer Inst. (1979) [Pubmed]
  23. The relative contribution of drug concentration and duration of exposure to mouse bone marrow toxicity during continuous methotrexate infusion. Pinedo, H.M., Zaharko, D.S., Bull, J., Chabner, B.A. Cancer Res. (1977) [Pubmed]
  24. Metabolism of 2-aminoanthracene by BALB/c and C57BL mammary epithelium in vitro. Silva, M.H., Petrakis, N.L., Musker, W.K., Talcott, R.E. Carcinogenesis (1985) [Pubmed]
  25. Immunocytochemical demonstration of day/night changes of clock gene protein levels in the murine adrenal gland: differences between melatonin-proficient (C3H) and melatonin-deficient (C57BL) mice. Torres-Farfan, C., Serón-Ferré, M., Dinet, V., Korf, H.W. J. Pineal Res. (2006) [Pubmed]
  26. Increased insulin mediated glucose metabolism in fat cells from I versus C57BL mice. Hoover-Plow, J., Guerre-Millo, M., Lavau, M. Proc. Soc. Exp. Biol. Med. (1987) [Pubmed]
  27. Quinoline: conversion to a mutagen by human and rodent liver. Hollstein, M., Talcott, R., Wei, E. J. Natl. Cancer Inst. (1978) [Pubmed]
  28. Kinetics of cell replication of the uterine cervix. III. Delayed migration in atypical epithelia of mice. Rubio, C.A., Zetterberg, A., Kock, Y., Sveander, M., Edenholm, M. J. Natl. Cancer Inst. (1980) [Pubmed]
  29. Direct antitumor effect of high-molecular-weight levan on Lewis lung carcinoma cells in mice. Leibovici, J., Susskind-Brudner, G., Wolman, M. J. Natl. Cancer Inst. (1980) [Pubmed]
  30. CREB in the mouse SCN: a molecular interface coding the phase-adjusting stimuli light, glutamate, PACAP, and melatonin for clockwork access. von Gall, C., Duffield, G.E., Hastings, M.H., Kopp, M.D., Dehghani, F., Korf, H.W., Stehle, J.H. J. Neurosci. (1998) [Pubmed]
  31. Effects of dimethylnitrosamine on RNA synthesis and metabolism in mouse liver. Garyfallides, S., Kyrtopoulos, S.A., Sekeris, C.E. Cancer Res. (1984) [Pubmed]
  32. Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitis. Fierer, J., Walls, L., Eckmann, L., Yamamoto, T., Kirkland, T.N. Infect. Immun. (1998) [Pubmed]
  33. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Heiman, M.L., Ahima, R.S., Craft, L.S., Schoner, B., Stephens, T.W., Flier, J.S. Endocrinology (1997) [Pubmed]
  34. Alterations in expression of dopamine receptors and neuropeptides in the striatum of GTP cyclohydrolase-deficient mice. Zeng, B.Y., Heales, S.J., Canevari, L., Rose, S., Jenner, P. Exp. Neurol. (2004) [Pubmed]
  35. Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system. Yamaguchi, Y., Kuo, M.T. Biochem. Pharmacol. (1995) [Pubmed]
  36. Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice. Kandere-Grzybowska, K., Gheorghe, D., Priller, J., Esposito, P., Huang, M., Gerard, N., Theoharides, T.C. Brain Res. (2003) [Pubmed]
  37. Ovariectomized murine model of postmenopausal calcium malabsorption. Kalu, D.N., Chen, C. J. Bone Miner. Res. (1999) [Pubmed]
  38. Tuberculosis DNA vaccine encoding Ag85A is immunogenic and protective when administered by intramuscular needle injection but not by epidermal gene gun bombardment. Tanghe, A., Denis, O., Lambrecht, B., Motte, V., van den Berg, T., Huygen, K. Infect. Immun. (2000) [Pubmed]
  39. Serum half-life and organ distribution of radiolabeled colony stimulating factor in mice. Burgess, A.W., Metcalf, D. Exp. Hematol. (1977) [Pubmed]
  40. The role of tumor necrosis factor in the development of multiple organ failure in a murine model. Burdon, D., Tiedje, T., Pfeffer, K., Vollmer, E., Zabel, P. Crit. Care Med. (2000) [Pubmed]
  41. Inhibitory effect of synthetic polyribonucleotides on the primary in vitro immune response. Johnson, H.M., Bukovic, J.A., Smith, B.G., Baron, S. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
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