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Chemical Compound Review:

Limettin 5,7-dimethoxychromen-2-one

Synonyms: Limetin, citropten, Citraptene, Citroptene, CHEMBL481049, ...

Jung, V. et al., Ashwood-Smith, M.J. et al., Makki, S. et al., Treffel, P. et al.

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Disease relevance of Limetin

In particular, the ultraviolet radiation-induced covalent addition of 5,7-dimethoxycoumarin to adenovirus DNA was increased by reducing the concentration of Na+ [1].
Some biological properties of 5,7-dimethoxycoumarin (DMC) include dark induced frameshift mutagenesis in bacteria, lethal photosensitization and the formation of sister chromatid exchanges in Chinese hamster cells [2].

High impact information on Limetin

Moreover, restriction enzyme analysis of the 5,7-dimethoxycoumarin-DNA photoadduct versus unmodified viral DNA, suggested that the sequence d(A-T) is the preferential site for intercalation and subsequent photobinding of 5,7-dimethoxycoumarin [1].
Specifically, 5,7-dimethoxycoumarin per 800 nucleotides in adenovirus DNA reduced the surviving fraction of adenovirus to a value of 0.1 after DNA infectivity (transfection) into human 293 cells [1].
Results suggest that 5,7-dimethoxycoumarin may be used for generating a limited 'library' of mutations in each of the five early gene regions of the adenovirus genome [1].

Biological context of Limetin

The photobinding of 5,7-dimethoxycoumarin to adenovirus type-2 DNA. A method for in vitro mutagenesis [1].

Analytical, diagnostic and therapeutic context of Limetin

The aim of this study was to quantify, using high-performance liquid chromatography, the amount of citropten and bergapten in the skin after suntan products application (an emulsion and an oil formulation) [3].
The aim of this study was to quantify, using HPLC, the amount of citropten and bergapten in the skin after the application of suntan products (emulsion and oil formulations) [4].

References

The photobinding of 5,7-dimethoxycoumarin to adenovirus type-2 DNA. A method for in vitro mutagenesis. Jung, V., Song, P.S., Harter, M.L. Biochim. Biophys. Acta (1983) [Pubmed]
Photobiological activity of 5,7-dimethoxycoumarin. Ashwood-Smith, M.J., Poulton, G.A., Liu, M. Experientia (1983) [Pubmed]
High-performance liquid chromatographic determination of citropten and bergapten in suction blister fluid after solar product application in humans. Makki, S., Treffel, P., Humbert, P., Agache, P. J. Chromatogr. (1991) [Pubmed]
Citropten and bergapten suction blister fluid concentrations after solar product application in man. Treffel, P., Makki, S., Faivre, B., Humbert, P., Blanc, D., Agache, P. Skin Pharmacol. (1991) [Pubmed]

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