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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Photosensitivity Disorders

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Disease relevance of Photosensitivity Disorders


High impact information on Photosensitivity Disorders


Chemical compound and disease context of Photosensitivity Disorders


Biological context of Photosensitivity Disorders


Anatomical context of Photosensitivity Disorders


Gene context of Photosensitivity Disorders

  • Thus, intracellular porphyrins synthesized from ALA are sufficient to elicit activation of p38 on photosensitization [24].
  • Indeed, TRAF6 dominant negative mutant abolished NF-kappaB activation by PPME photosensitization, and TRAF2 dominant negative mutant was without any effect, and overexpression of IkappaB kinases increased gene transcription controlled by NF-kappaB [16].
  • We have investigated the role of singlet oxygen, an ROS formed by photosensitization, in the regulation of survival signaling via the epidermal growth factor receptor (EGFR) [25].
  • Our data show that photosensitization with the new photosensitizer 9-HPbD could induce the apoptotic death of MCF-7 breast cancer cell and that this death is mediated by stress-activated signal through JNK [26].
  • We conclude that UVB preirradiation and photosensitization result in the generation of V beta 7+ Th2 cells that suppress contact photosensitivity by releasing IL-10 [27].

Analytical, diagnostic and therapeutic context of Photosensitivity Disorders


  1. Rapid electrophysiological changes leading to arrhythmias in the aerobic rat heart. Photosensitization studies with rose bengal-derived reactive oxygen intermediates. Hearse, D.J., Kusama, Y., Bernier, M. Circ. Res. (1989) [Pubmed]
  2. Effects of photosensitization by hematoporphyrin derivative on mitochondrial adenosine triphosphatase-mediated proton transport and membrane integrity of R3230AC mammary adenocarcinoma. Perlin, D.S., Murant, R.S., Gibson, S.L., Hilf, R. Cancer Res. (1985) [Pubmed]
  3. Photosensitization of leukemia L1210 cells with diaziquone. Kessel, D., Thompson, P. Cancer Res. (1986) [Pubmed]
  4. Dye-mediated photosensitization of murine neuroblastoma cells. Sieber, F., Sieber-Blum, M. Cancer Res. (1986) [Pubmed]
  5. Mitochondrial function is involved in LDL oxidation mediated by human cultured endothelial cells. Mabile, L., Meilhac, O., Escargueil-Blanc, I., Troly, M., Pieraggi, M.T., Salvayre, R., Nègre-Salvayre, A. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  6. Merocyanine 540 as a fluorescent probe of membranes: staining of electrically excitable cells. Easton, T.G., Valinsky, J.E., Reich, E. Cell (1978) [Pubmed]
  7. A novel mechanism for the generation of superoxide anions in hematoporphyrin derivative-mediated cutaneous photosensitization. Activation of the xanthine oxidase pathway. Athar, M., Elmets, C.A., Bickers, D.R., Mukhtar, H. J. Clin. Invest. (1989) [Pubmed]
  8. Photosensitization to benoxaprofen not due to ultraviolet A alone. Fenton, D.A., Wilkinson, J.D., English, J.S. Lancet (1981) [Pubmed]
  9. Selective killing of leukemic cells by merocyanine 540-mediated photosensitization. Sieber, F., Spivak, J.L., Sutcliffe, A.M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  10. Targeted killing of cultured cells by receptor-dependent photosensitization. Mosley, S.T., Goldstein, J.L., Brown, M.S., Falck, J.R., Anderson, R.G. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  11. Selective labeling of proteins in biological systems by photosensitization of 5-iodonaphthalene-1-azide. Raviv, Y., Salomon, Y., Gitler, C., Bercovici, T. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  12. Inactivation of Friend erythroleukemia virus and Friend virus-transformed cells by merocyanine 540-mediated photosensitization. Sieber, F., Krueger, G.J., O'Brien, J.M., Schober, S.L., Sensenbrenner, L.L., Sharkis, S.J. Blood (1989) [Pubmed]
  13. Glucose regulated protein induction and cellular resistance to oxidative stress mediated by porphyrin photosensitization. Gomer, C.J., Ferrario, A., Rucker, N., Wong, S., Lee, A.S. Cancer Res. (1991) [Pubmed]
  14. Celecoxib and NS-398 enhance photodynamic therapy by increasing in vitro apoptosis and decreasing in vivo inflammatory and angiogenic factors. Ferrario, A., Fisher, A.M., Rucker, N., Gomer, C.J. Cancer Res. (2005) [Pubmed]
  15. Transcription factor NF-kappa B is activated by photosensitization generating oxidative DNA damages. Legrand-Poels, S., Bours, V., Piret, B., Pflaum, M., Epe, B., Rentier, B., Piette, J. J. Biol. Chem. (1995) [Pubmed]
  16. Pyropheophorbide-a methyl ester-mediated photosensitization activates transcription factor NF-kappaB through the interleukin-1 receptor-dependent signaling pathway. Matroule, J.Y., Bonizzi, G., Morlière, P., Paillous, N., Santus, R., Bours, V., Piette, J. J. Biol. Chem. (1999) [Pubmed]
  17. Photosnesitization of DNA by gold. Wilkins, R.J. Nucleic Acids Res. (1978) [Pubmed]
  18. Differential role of reactive oxygen intermediates in photofrin-I- and photofrin-II-mediated photoenhancement of lipid peroxidation in epidermal microsomal membranes. Athar, M., Mukhtar, H., Bickers, D.R. J. Invest. Dermatol. (1988) [Pubmed]
  19. Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomas. Gibson, S.L., Murant, R.S., Hilf, R. Cancer Res. (1988) [Pubmed]
  20. Inhibition of the high affinity Fc receptor (Fc gamma RI) on human monocytes by porphyrin photosensitization is highly specific and mediated by the generation of superoxide radicals. Krutmann, J., Athar, M., Mendel, D.B., Khan, I.U., Guyre, P.M., Mukhtar, H., Elmets, C.A. J. Biol. Chem. (1989) [Pubmed]
  21. Phototoxicity mechanisms: chlorpromazine photosensitized damage to DNA and cell membranes. Kochevar, K.E. J. Invest. Dermatol. (1981) [Pubmed]
  22. Susceptibility to merocyanine 540-mediated photosensitization: a differentiation marker on murine hematopoietic progenitor cells. Meagher, R.C., Sieber, F., Spivak, J.L. J. Cell. Physiol. (1983) [Pubmed]
  23. Detection of nearest neighbors to specific fluorescently tagged ligands in rod outer segment and lymphocyte plasma membranes by photosensitization of 5-iodonaphthyl 1-azide. Raviv, Y., Bercovici, T., Gitler, C., Salomon, Y. Biochemistry (1989) [Pubmed]
  24. Activation of JNK and p38 but not ERK MAP kinases in human skin cells by 5-aminolevulinate-photodynamic therapy. Klotz, L.O., Fritsch, C., Briviba, K., Tsacmacidis, N., Schliess, F., Sies, H. Cancer Res. (1998) [Pubmed]
  25. Downregulation of epidermal growth factor receptor signaling by singlet oxygen through activation of caspase-3 and protein phosphatases. Zhuang, S., Ouedraogo, G.D., Kochevar, I.E. Oncogene (2003) [Pubmed]
  26. 9-Hydroxypheophorbide alpha-induced apoptotic death of MCF-7 breast cancer cells is mediated by c-Jun N-terminal kinase activation. Choi, S.E., Sohn, S., Cho, J.W., Shin, E.A., Song, P.S., Kang, Y. J. Photochem. Photobiol. B, Biol. (2004) [Pubmed]
  27. TCRV beta 7+ Th2 cells mediate UVB-induced suppression of murine contact photosensitivity by releasing IL-10. Yagi, H., Tokura, Y., Wakita, H., Furukawa, F., Takigawa, M. J. Immunol. (1996) [Pubmed]
  28. Kinetic analysis of the deamination reactions of cyclobutane dimers of thymidylyl-3',5'-2'-deoxycytidine and 2'-deoxycytidylyl-3',5'-thymidine. Lemaire, D.G., Ruzsicska, B.P. Biochemistry (1993) [Pubmed]
  29. A regulatory role for porphobilinogen deaminase (PBGD) in delta-aminolaevulinic acid (delta-ALA)-induced photosensitization? Gibson, S.L., Cupriks, D.J., Havens, J.J., Nguyen, M.L., Hilf, R. Br. J. Cancer (1998) [Pubmed]
  30. Virus inactivation in red cell concentrates by photosensitization with phthalocyanines: protection of red cells but not of vesicular stomatitis virus with a water-soluble analogue of vitamin E. Ben-Hur, E., Rywkin, S., Rosenthal, I., Geacintov, N.E., Horowitz, B. Transfusion (1995) [Pubmed]
  31. Photosensitization of cystine stones to induce laser lithotripsy. Tasca, A., Cecchetti, W., Zattoni, F., Pagano, F. J. Urol. (1993) [Pubmed]
  32. Efficient photodynamic action of Victoria blue BO against the human leukemic cell lines K-562 and TF-1. Fiedorowicz, M., Galindo, J.R., Julliard, M., Mannoni, P., Chanon, M. Photochem. Photobiol. (1993) [Pubmed]
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