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Chemical Compound Review:

Tetridamin N,2-dimethyl-4,5,6,7- tetrahydroindazol-3...

Synonyms: TETRYDAMINE, Tetridamina, Tetridamine, Tetridaminum, POLI 67, ...

Manzardo, S. et al.

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Disease relevance of POLI 67

Clinical studies (4 open and 1 double-blind) were performed on 93 women suffering from vulvovaginitis and cervicitis by treatment of 0.134% tetridamine vaginal lavage, two times daily, for 7 days [1].

High impact information on POLI 67

A 28 days vaginal tolerability study performed on Sprague-Dawley rats with tetridamine lavage (0.2 ml/rat/day) showed, in comparison with control group, no changes in haematology, coagulation, clinical biochemistry and in histological examinations of uterus and vagina [1].

Analytical, diagnostic and therapeutic context of POLI 67

Activity and tolerability of tetridamine vaginal lavage in rats and women [1].
Tetridamine lavage reduced or eliminated all inflammation symptoms like burning, leucorrhea, etc. and resulted very well tolerated [1].

References

Activity and tolerability of tetridamine vaginal lavage in rats and women. Manzardo, S., Girardello, R., Pinzetta, A., Coppi, G., De Aloysio, D. Bollettino chimico farmaceutico. (1992) [Pubmed]

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