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Chemical Compound Review:

UPCMLD-DP047 2,3,4,6,7,8,9,9a-octahydro- 1H-quinolizin-1...

Synonyms: SureCN914675, AG-A-06877, AG-D-08745, CCG-47843, NSC-168348, ...

Sparatore, A. et al., Brosius, A.D. et al.

Sparatore, Cagnotto, Sparatore, Brosius, Ziller, Zhang,

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High impact information on Lupinine

Five 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives of lupinine, epi-lupinine and lupinylamine, together with two 1-homolupinanoyl benzimidazolones were prepared and investigated for their ability to displace specific radioligands from 5-HT3 and 5-HT4 receptors [1].
Two X-ray structures, one of the free base of the alkaloid and the second of its dihydrochloride monohydrate salt, C15H26N2(2+).2Cl-.H2O, have been determined to unequivocally establish the stereochemistry of aloperine, the parent member of a rare family of lupinine alkaloids [2].

References

Quinolizidinyl derivatives of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid and 1-homolupinanoyl benzimidazolones as ligands for 5-HT3 and 5-HT4 receptors. Sparatore, A., Cagnotto, A., Sparatore, F. Farmaco (1999) [Pubmed]
Relative and absolute configuration of aloperine. Brosius, A.D., Ziller, J.W., Zhang, Q. Acta crystallographica. Section C, Crystal structure communications. (1997) [Pubmed]

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