Gene Review:
Htr4 - 5-hydroxytryptamine (serotonin) receptor 4...
Rattus norvegicus
Synonyms:
5-HT-4, 5-HT4, 5-hydroxytryptamine receptor 4, Serotonin receptor 4
- L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Smriga, M., Torii, K. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists. Lucas, G., Compan, V., Charnay, Y., Neve, R.L., Nestler, E.J., Bockaert, J., Barrot, M., Debonnel, G. Biol. Psychiatry (2005)
- Molecular and behavioral effects mediated by Gs-coupled adenosine A2a, but not serotonin 5-Ht4 or 5-Ht6 receptors following antipsychotic administration. Ward, R.P., Dorsa, D.M. Neuroscience (1999)
- Pharmacological analyses of endo-6-methoxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-2,3-dihydro-2-oxo-1 H- benzimidazole-1-carboxylate hydrochloride (DAU 6285) at the 5-hydroxytryptamine4 receptor in the tunica muscularis mucosae of rat esophagus and ileum of guinea pig: role of endogenous 5-hydroxytryptamine. Waikar, M.V., Hegde, S.S., Ford, A.P., Clarke, D.E. J. Pharmacol. Exp. Ther. (1993)
- 5-HT4 receptors in the hippocampus modulate rat locomotor activity. Takahashi, H., Takada, Y., Urano, T., Takada, A. Hippocampus. (2002)
- BIMU1 increases associative memory in rats by activating 5-HT4 receptors. Marchetti-Gauthier, E., Roman, F.S., Dumuis, A., Bockaert, J., Soumireu-Mourat, B. Neuropharmacology (1997)
- Anxiolytic-like actions of the selective 5-HT4 receptor antagonists SB 204070A and SB 207266A in rats. Kennett, G.A., Bright, F., Trail, B., Blackburn, T.P., Sanger, G.J. Neuropharmacology (1997)
- 5-HT4 receptors improve social olfactory memory in the rat. Letty, S., Child, R., Dumuis, A., Pantaloni, A., Bockaert, J., Rondouin, G. Neuropharmacology (1997)
- Regional distribution and ontogeny of 5-HT4 binding sites in rat brain. Waeber, C., Sebben, M., Bockaert, J., Dumuis, A. Behav. Brain Res. (1996)
- 5HT4 receptors couple positively to tetrodotoxin-insensitive sodium channels in a subpopulation of capsaicin-sensitive rat sensory neurons. Cardenas, C.G., Del Mar, L.P., Cooper, B.Y., Scroggs, R.S. J. Neurosci. (1997)
- The 5-hydroxytryptamine4 receptor exhibits frequency-dependent properties in synaptic plasticity and behavioural metaplasticity in the hippocampal CA1 region in vivo. Kemp, A., Manahan-Vaughan, D. Cereb. Cortex (2005)
- Effects of serotonin on rat ileocolonic transit and fluid transfer in vivo: possible mechanisms of action. Oosterbosch, L., von der Ohe, M., Valdovinos, M.A., Kost, L.J., Phillips, S.F., Camilleri, M. Gut (1993)
- The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors. Eglen, R.M., Alvarez, R., Johnson, L.G., Leung, E., Wong, E.H. Br. J. Pharmacol. (1993)
- p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors. Yamada, J., Sugimoto, Y., Yoshikawa, T. Eur. J. Pharmacol. (1998)
- Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor. Yamada, J., Sugimoto, Y., Yoshikawa, T., Horisaka, K. Eur. J. Pharmacol. (1997)
- Effects of the 5-HT2C/2B receptor agonist 1-(3-chlorophenyl) piperazine on plasma glucose levels of rats. Sugimoto, Y., Yamada, J., Yoshikawa, T., Horisaka, K. Eur. J. Pharmacol. (1996)
- Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties. Monge, A., Peña, M.C., Palop, J.A., Calderó, J.M., Roca, J., García, E., Romero, G., del Río, J., Lasheras, B. J. Med. Chem. (1994)
- Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: indazole and benzimidazolone derivatives. Schaus, J.M., Thompson, D.C., Bloomquist, W.E., Susemichel, A.D., Calligaro, D.O., Cohen, M.L. J. Med. Chem. (1998)
- Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Eglen, R.M., Bonhaus, D.W., Johnson, L.G., Leung, E., Clark, R.D. Br. J. Pharmacol. (1995)
- Acquisition, retention, and recall of memory after injection of RS67333, a 5-HT(4) receptor agonist, into the nucleus basalis magnocellularis of the rat. Orsetti, M., Dellarole, A., Ferri, S., Ghi, P. Learn. Mem. (2003)
- Lasting increase in serotonin 5-HT1A but not 5-HT4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects. Cagnotto, A., Crespi, D., Mancini, L., Manzoni, C., Presti, M.L., Gariboldi, M., Vezzani, A., Mennini, T. J. Neurochem. (1998)
- Arylcarbamate derivatives of 1-piperidineethanol as potent ligands for 5-HT4 receptors. Soulier, J.L., Yang, D., Brémont, B., Croci, T., Guzzi, U., Langlois, M. J. Med. Chem. (1997)
- Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists. López-Rodríguez, M.L., Benhamú, B., Murcia, M., Alvaro, E., Campillo, M., Pardo, L. J. Comput. Aided Mol. Des. (2003)
- Cyclic AMP and protein kinase A mediate 5-hydroxytryptamine type 4 receptor regulation of calcium-activated potassium current in adult hippocampal neurons. Torres, G.E., Chaput, Y., Andrade, R. Mol. Pharmacol. (1995)
- Benzimidazole derivatives. Part 1: Synthesis and structure-activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists. López-Rodríguez, M.L., Benhamú, B., Viso, A., Morcillo, M.J., Murcia, M., Orensanz, L., Alfaro, M.J., Martín, M.I. Bioorg. Med. Chem. (1999)
- 5-HT4 receptor antagonism potentiates inhibition of intestinal allodynia by 5-HT3 receptor antagonism in conscious rats. Smith, M.I., Banner, S.E., Sanger, G.J. Neurosci. Lett. (1999)
- 5-Hydroxytryptamine1A and 5-hydroxytryptamine1B receptors stimulate [35S]guanosine-5'-O-(3-thio)triphosphate binding to rodent brain sections as visualized by in vitro autoradiography. Waeber, C., Moskowitz, M.A. Mol. Pharmacol. (1997)
- 5-hydroxytryptamine stimulates glucose transport in cardiomyocytes via a monoamine oxidase-dependent reaction. Fischer, Y., Thomas, J., Kamp, J., Jüngling, E., Rose, H., Carpéné, n.u.l.l., Kammermeier, H. Biochem. J. (1995)
- 5-HT1A and 5-HT4 receptor colocalization on hippocampal pyramidal cells. Roychowdhury, S., Haas, H., Anderson, E.G. Neuropharmacology (1994)
- Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. Xiang, Z., Wang, L., Kitai, S.T. J. Neurophysiol. (2005)
- Quantitative autoradiography of 5-HT4 receptors in brains of three species using two structurally distinct radioligands, [3H]GR113808 and [3H]BIMU-1. Jakeman, L.B., To, Z.P., Eglen, R.M., Wong, E.H., Bonhaus, D.W. Neuropharmacology (1994)
- Receptor mechanisms involved in the 5-HT-induced inotropic action in the rat isolated atrium. Läer, S., Remmers, F., Scholz, H., Stein, B., Müller, F.U., Neumann, J. Br. J. Pharmacol. (1998)
- Localization of 5-HT4 receptor mRNA in rat brain by in situ hybridization histochemistry. Vilaró, M.T., Cortés, R., Gerald, C., Branchek, T.A., Palacios, J.M., Mengod, G. Brain Res. Mol. Brain Res. (1996)