Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1MHZTJ nitroso(2S)-2-amino-4- sulfanyl-butanoate

Synonyms: L-Homocysteine, nitrite (ester), nitroso (2S)-2-amino-4-sulfanylbutanoate

Fu, W.Y. et al., Lee, S.J. et al., Cassone Faldetta, M. et al., Kim, W.K.

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High impact information on S-Nitrosohomocysteine

Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine [1].
In vitro, nitric oxide decreases homocysteine by its conversion to the vasodilative and antioxidant compound S-nitrosohomocysteine [2].
Vasodilators including NO donors: S-nitrosohomocysteine (SNOHcy), S-nitrosocysteine (SNOCys) and sodium nitroprusside (SNP), the endothelial NO synthase (eNOS) activator: acetylcholine (ACh), and calcium channel blocker: verapamil and nicardipine, were administered by one bolus injection to the homocysteinemic rats [3].
Like HC, S-nitrosohomocysteine increased the intracellular calcium concentration ([Ca2+]i) via NMDA receptor [4].

References

Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine. Lee, S.J., Kim, K.M., Namkoong, S., Kim, C.K., Kang, Y.C., Lee, H., Ha, K.S., Han, J.A., Chung, H.T., Kwon, Y.G., Kim, Y.M. J. Biol. Chem. (2005) [Pubmed]
L-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in Type II diabetic patients. Cassone Faldetta, M., Laurenti, O., Desideri, G., Bravi, M.C., De Luca, O., Marinucci, M.C., De Mattia, G., Ferri, C. Diabetologia (2002) [Pubmed]
Homocysteine attenuates hemodynamic responses to nitric oxide in vivo. Fu, W.Y., Dudman, N.P., Perry, M.A., Wang, X.L. Atherosclerosis (2002) [Pubmed]
S-nitrosation ameliorates homocysteine-induced neurotoxicity and calcium responses in primary culture of rat cortical neurons. Kim, W.K. Neurosci. Lett. (1999) [Pubmed]

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