Chemical Compound Review:
L-Homocysteine (2S)-2-amino-4-sulfanyl- butanoic acid
Synonyms:
CHEMBL469662, AG-F-57853, AG-G-15653, CHEBI:17588, AC1L3MAY, ...
Tice,
Ross,
Coxson,
Rosenberg,
Weinstein,
Hunink,
Goldman,
Williams,
Goldman,
Ridker,
Manson,
Buring,
Shih,
Matias,
Hennekens,
den Heijer,
Willems,
Blom,
Gerrits,
Cattaneo,
Eichinger,
Rosendaal,
Bos,
Mattson,
Shea,
Wang,
Jiang,
Yang,
Chapman,
Durante,
Sibinga,
Schafer,
Ji,
Kaplowitz,
Schnyder,
Roffi,
Pin,
Flammer,
Lange,
Eberli,
Meier,
Turi,
Hess,
Dufouil,
Alpérovitch,
Ducros,
Tzourio,
Osganian,
Stampfer,
Spiegelman,
Rimm,
Cutler,
Feldman,
Montgomery,
Webber,
Lytle,
Bausserman,
Nader,
Fairfield,
Fletcher,
- Hyperhomocysteinemia: an independent risk factor for vascular disease. Clarke, R., Daly, L., Robinson, K., Naughten, E., Cahalane, S., Fowler, B., Graham, I. N. Engl. J. Med. (1991)
- Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. den Heijer, M., Koster, T., Blom, H.J., Bos, G.M., Briet, E., Reitsma, P.H., Vandenbroucke, J.P., Rosendaal, F.R. N. Engl. J. Med. (1996)
- Plasma homocysteine levels and mortality in patients with coronary artery disease. Nygård, O., Nordrehaug, J.E., Refsum, H., Ueland, P.M., Farstad, M., Vollset, S.E. N. Engl. J. Med. (1997)
- Correction of disease-causing CBS mutations in yeast. Shan, X., Kruger, W.D. Nat. Genet. (1998)
- Neural-tube defects and derangement of homocysteine metabolism. Steegers-Theunissen, R.P., Boers, G.H., Trijbels, F.J., Eskes, T.K. N. Engl. J. Med. (1991)
- Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial. den Heijer, M., Willems, H.P., Blom, H.J., Gerrits, W.B., Cattaneo, M., Eichinger, S., Rosendaal, F.R., Bos, G.M. Blood (2007)
- Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study. Vermeer, S.E., van Dijk, E.J., Koudstaal, P.J., Oudkerk, M., Hofman, A., Clarke, R., Breteler, M.M. Ann. Neurol. (2002)
- Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. Kruman, I.I., Culmsee, C., Chan, S.L., Kruman, Y., Guo, Z., Penix, L., Mattson, M.P. J. Neurosci. (2000)
- Homocysteine, white matter hyperintensities, and cognition in healthy elderly people. Dufouil, C., Alpérovitch, A., Ducros, V., Tzourio, C. Ann. Neurol. (2003)
- Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats. Blaise, S.A., Nédélec, E., Schroeder, H., Alberto, J.M., Bossenmeyer-Pourié, C., Guéant, J.L., Daval, J.L. Am. J. Pathol. (2007)
- Structure-based perspectives on B12-dependent enzymes. Ludwig, M.L., Matthews, R.G. Annu. Rev. Biochem. (1997)
- Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. Schnyder, G., Roffi, M., Pin, R., Flammer, Y., Lange, H., Eberli, F.R., Meier, B., Turi, Z.G., Hess, O.M. N. Engl. J. Med. (2001)
- Mutations in coagulation factors in women with unexplained late fetal loss. Martinelli, I., Taioli, E., Cetin, I., Marinoni, A., Gerosa, S., Villa, M.V., Bozzo, M., Mannucci, P.M. N. Engl. J. Med. (2000)
- Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. Malinow, M.R., Duell, P.B., Hess, D.L., Anderson, P.H., Kruger, W.D., Phillipson, B.E., Gluckman, R.A., Block, P.C., Upson, B.M. N. Engl. J. Med. (1998)
- Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. Selhub, J., Jacques, P.F., Bostom, A.G., D'Agostino, R.B., Wilson, P.W., Belanger, A.J., O'Leary, D.H., Wolf, P.A., Schaefer, E.J., Rosenberg, I.H. N. Engl. J. Med. (1995)
- Homocystinuria--the effects of betaine in the treatment of patients not responsive to pyridoxine. Wilcken, D.E., Wilcken, B., Dudman, N.P., Tyrrell, P.A. N. Engl. J. Med. (1983)
- Vitamins for chronic disease prevention in adults: scientific review. Fairfield, K.M., Fletcher, R.H. JAMA (2002)
- Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. Stamler, J.S., Osborne, J.A., Jaraki, O., Rabbani, L.E., Mullins, M., Singel, D., Loscalzo, J. J. Clin. Invest. (1993)
- Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Ji, C., Kaplowitz, N. Gastroenterology (2003)
- Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Goyette, P., Sumner, J.S., Milos, R., Duncan, A.M., Rosenblatt, D.S., Matthews, R.G., Rozen, R. Nat. Genet. (1994)
- Homocysteine antagonism of nitric oxide-related cytostasis in Salmonella typhimurium. De Groote, M.A., Testerman, T., Xu, Y., Stauffer, G., Fang, F.C. Science (1996)
- MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. Klerk, M., Verhoef, P., Clarke, R., Blom, H.J., Kok, F.J., Schouten, E.G. JAMA (2002)
- Distribution of and factors associated with serum homocysteine levels in children: Child and Adolescent Trial for Cardiovascular Health. Osganian, S.K., Stampfer, M.J., Spiegelman, D., Rimm, E., Cutler, J.A., Feldman, H.A., Montgomery, D.H., Webber, L.S., Lytle, L.A., Bausserman, L., Nader, P.R. JAMA (1999)
- Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Mattson, M.P., Shea, T.B. Trends Neurosci. (2003)
- Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. Nappo, F., De Rosa, N., Marfella, R., De Lucia, D., Ingrosso, D., Perna, A.F., Farzati, B., Giugliano, D. JAMA (1999)
- Capping and adenosine metabolism. Genetic and pharmacologic studies. Braun, J., Rosen, F.S., Unanue, E.R. J. Exp. Med. (1980)
- Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. Tsai, J.C., Wang, H., Perrella, M.A., Yoshizumi, M., Sibinga, N.E., Tan, L.C., Haber, E., Chang, T.H., Schlegel, R., Lee, M.E. J. Clin. Invest. (1996)
- A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Frosst, P., Blom, H.J., Milos, R., Goyette, P., Sheppard, C.A., Matthews, R.G., Boers, G.J., den Heijer, M., Kluijtmans, L.A., van den Heuvel, L.P. Nat. Genet. (1995)
- Cost-effectiveness of vitamin therapy to lower plasma homocysteine levels for the prevention of coronary heart disease: effect of grain fortification and beyond. Tice, J.A., Ross, E., Coxson, P.G., Rosenberg, I., Weinstein, M.C., Hunink, M.G., Goldman, P.A., Williams, L., Goldman, L. JAMA (2001)
- Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. Ridker, P.M., Stampfer, M.J., Rifai, N. JAMA (2001)
- Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient. Kluijtmans, L.A., Boers, G.H., Stevens, E.M., Renier, W.O., Kraus, J.P., Trijbels, F.J., van den Heuvel, L.P., Blom, H.J. J. Clin. Invest. (1996)
- Disposition of endogenous homocysteine by mouse fibroblast C3H/10T1/2 Cl 8 and the chemically transformed C3H/10T1/2 MCA Cl 16 cells following methotrexate exposure. Ueland, P.M., Refsum, H., Male, R., Lillehaug, J.R. J. Natl. Cancer Inst. (1986)
- Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations. Chamberlin, M.E., Ubagai, T., Mudd, S.H., Thomas, J., Pao, V.Y., Nguyen, T.K., Levy, H.L., Greene, C., Freehauf, C., Chou, J.Y. Am. J. Hum. Genet. (2000)
- Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Winter-Vann, A.M., Kamen, B.A., Bergo, M.O., Young, S.G., Melnyk, S., James, S.J., Casey, P.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element. Cai, Y., Zhang, C., Nawa, T., Aso, T., Tanaka, M., Oshiro, S., Ichijo, H., Kitajima, S. Blood (2000)
- Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition. Wang, H., Jiang, X., Yang, F., Chapman, G.B., Durante, W., Sibinga, N.E., Schafer, A.I. Blood (2002)
- Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. Roybal, C.N., Yang, S., Sun, C.W., Hurtado, D., Vander Jagt, D.L., Townes, T.M., Abcouwer, S.F. J. Biol. Chem. (2004)
- Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. Selhub, J., Jacques, P.F., Wilson, P.W., Rush, D., Rosenberg, I.H. JAMA (1993)
- Homocysteine and risk of cardiovascular disease among postmenopausal women. Ridker, P.M., Manson, J.E., Buring, J.E., Shih, J., Matias, M., Hennekens, C.H. JAMA (1999)