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Chemical Compound Review

C-Ibza-MU     (2S,3S,4R,5R)-5-[2-chloro-6- [(3...

Synonyms: CI-IB-MECA, Cl-IB-MECA, CHEMBL431733, C277_SIGMA, CF-102, ...
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High impact information on C-Ibza-MU

  • Also, the ability of 2Cl-IB-MECA to inhibit lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo was decreased in A3AR(-/-) mice in comparison to A3AR(+/+) mice [1].
  • In contrast, CPA, CGS 21680 and 2-Cl-IB-MECA, agonists selective for A(1) A(2A) and A(3) receptors, respectively, induced no, or minimal, bronchoconstriction [2].
  • The effects of the A(3) adenosine receptor agonist 2-Cl-IB-MECA were tested on epileptiform field potentials recorded in the CA3 area of postnatal days 10-20 immature hippocampal slices, during perfusion with the GABA(A) receptor antagonist bicuculline (10 microM) [3].
  • Furthermore, the capacity of 2-Cl-IB-MECA to modulate cytokine responses was greatly diminished when the drug was administered to mast cell deficient (WBB6F-W/W(V)) mice [4].
  • The hemodynamic effects of the novel, selective adenosine A3 receptor agonist 2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide (2-Cl-IB-MECA) were investigated in conscious rats [5].

Analytical, diagnostic and therapeutic context of C-Ibza-MU

  • Hearts were divided into four groups: (1) no pretreatment (PTx) and unsupplemented cardioplegia (CP) (control), (2) Cl-IB-MECA PTx and unsupplemented CP (A3-PTx), (3) no PTx and Cl-IB-MECA CP (A3-CP), or (4) Cl-IB-MECA PTx and Cl-IB-MECA CP (A3-[PTx+CP]) [6].


  1. Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells. Salvatore, C.A., Tilley, S.L., Latour, A.M., Fletcher, D.S., Koller, B.H., Jacobson, M.A. J. Biol. Chem. (2000) [Pubmed]
  2. Evidence for an atypical receptor mediating the augmented bronchoconstrictor response to adenosine induced by allergen challenge in actively sensitized Brown Norway rats. Hannon, J.P., Tigani, B., Wolber, C., Williams, I., Mazzoni, L., Howes, C., Fozard, J.R. Br. J. Pharmacol. (2002) [Pubmed]
  3. The A3 adenosine receptor agonist 2-Cl-IB-MECA facilitates epileptiform discharges in the CA3 area of immature rat hippocampal slices. Laudadio, M.A., Psarropoulou, C. Epilepsy Res. (2004) [Pubmed]
  4. A role for histamine in cytokine modulation by the adenosine A(3) receptor agonist, 2-Cl-IB-MECA. Smith, S.R., Denhardt, G., Terminelli, C. Eur. J. Pharmacol. (2002) [Pubmed]
  5. Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats. Van Schaick, E.A., Jacobson, K.A., Kim, H.O., IJzerman, A.P., Danhof, M. Eur. J. Pharmacol. (1996) [Pubmed]
  6. Adenosine A3 pretreatment before cardioplegic arrest attenuates postischemic cardiac dysfunction. Thourani, V.H., Ronson, R.S., Jordan, J.E., Guyton, R.A., Vinten-Johansen, J. Ann. Thorac. Surg. (1999) [Pubmed]
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