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Gene Review

Lpsi1  -  lipopolysaccharide induced gene 1

Mus musculus

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Disease relevance of Lpsi1


Psychiatry related information on Lpsi1


High impact information on Lpsi1


Chemical compound and disease context of Lpsi1


Biological context of Lpsi1


Anatomical context of Lpsi1


Associations of Lpsi1 with chemical compounds


Physical interactions of Lpsi1


Enzymatic interactions of Lpsi1


Regulatory relationships of Lpsi1


Other interactions of Lpsi1


Analytical, diagnostic and therapeutic context of Lpsi1


  1. Inducible histamine protects mice from P. acnes-primed and LPS-induced hepatitis through H2-receptor stimulation. Yokoyama, M., Yokoyama, A., Mori, S., Takahashi, H.K., Yoshino, T., Watanabe, T., Watanabe, T., Ohtsu, H., Nishibori, M. Gastroenterology (2004) [Pubmed]
  2. Recombinant Soluble Forms of Extracellular TLR4 Domain and MD-2 Inhibit Lipopolysaccharide Binding on Cell Surface and Dampen Lipopolysaccharide-Induced Pulmonary Inflammation in Mice. Mitsuzawa, H., Nishitani, C., Hyakushima, N., Shimizu, T., Sano, H., Matsushima, N., Fukase, K., Kuroki, Y. J. Immunol. (2006) [Pubmed]
  3. Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice. Robertson, S.A., Skinner, R.J., Care, A.S. J. Immunol. (2006) [Pubmed]
  4. Fibronectin prevents D-galactosamine/lipopolysaccharide-induced lethal hepatic failure in mice. Qiu, Z., Kwon, A.H., Tsuji, K., Kamiyama, Y., Okumura, T., Hirao, Y. Shock (2006) [Pubmed]
  5. Tolerance to lipopolysaccharide-induced increase in vascular permeability in mouse skin. Fujii, E., Irie, K., Uchida, Y., Tsukahara, F., Ohba, K., Ogawa, A., Muraki, T. Eur. J. Pharmacol. (1996) [Pubmed]
  6. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. Kitazawa, M., Oddo, S., Yamasaki, T.R., Green, K.N., LaFerla, F.M. J. Neurosci. (2005) [Pubmed]
  7. An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Roy, C.N., Custodio, A.O., de Graaf, J., Schneider, S., Akpan, I., Montross, L.K., Sanchez, M., Gaudino, A., Hentze, M.W., Andrews, N.C., Muckenthaler, M.U. Nat. Genet. (2004) [Pubmed]
  8. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., Wong, W., Kamen, R., Tracey, D., Allen, H. Nature (1997) [Pubmed]
  9. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Novogrodsky, A., Vanichkin, A., Patya, M., Gazit, A., Osherov, N., Levitzki, A. Science (1994) [Pubmed]
  10. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., Ichijo, H. Nat. Immunol. (2005) [Pubmed]
  11. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Karaghiosoff, M., Steinborn, R., Kovarik, P., Kriegshäuser, G., Baccarini, M., Donabauer, B., Reichart, U., Kolbe, T., Bogdan, C., Leanderson, T., Levy, D., Decker, T., Müller, M. Nat. Immunol. (2003) [Pubmed]
  12. Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1. Jin, S.W., Zhang, L., Lian, Q.Q., Liu, D., Wu, P., Yao, S.L., Ye, D.Y. Anesth. Analg. (2007) [Pubmed]
  13. Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice. Legssyer, R., Huaux, F., Lebacq, J., Delos, M., Marbaix, E., Lebecque, P., Lison, D., Scholte, B.J., Wallemacq, P., Leal, T. Respir. Res. (2006) [Pubmed]
  14. Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Kotanidou, A., Xagorari, A., Bagli, E., Kitsanta, P., Fotsis, T., Papapetropoulos, A., Roussos, C. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  15. Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion. Shapira, L., Soskolne, W.A., Houri, Y., Barak, V., Halabi, A., Stabholz, A. Infect. Immun. (1996) [Pubmed]
  16. Modulation of lipopolysaccharide-induced macrophage gene expression by Rhodobacter sphaeroides lipid A and SDZ 880.431. Manthey, C.L., Perera, P.Y., Qureshi, N., Stütz, P.L., Hamilton, T.A., Vogel, S.N. Infect. Immun. (1993) [Pubmed]
  17. Characterization of lipopolysaccharide-induced macrophage gene expression. Tannenbaum, C.S., Koerner, T.J., Jansen, M.M., Hamilton, T.A. J. Immunol. (1988) [Pubmed]
  18. Pharmacological modulation of myocardial tumor necrosis factor alpha production by phosphodiesterase inhibitors. Bergman, M.R., Holycross, B.J. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  19. Lipopolysaccharide-induced liver apoptosis is increased in interleukin-10 knockout mice. Zhong, J., Deaciuc, I.V., Burikhanov, R., de Villiers, W.J. Biochim. Biophys. Acta (2006) [Pubmed]
  20. The Lipopolysaccharide-Induced Up-Regulation of Bradykinin B(2)-Receptor in the Mouse Heart Is Mediated by Tumor Necrosis Factor-alpha and Angiotensin II. Yayama, K., Hiyoshi, H., Sugiyama, K., Okamoto, H. Biol. Pharm. Bull. (2006) [Pubmed]
  21. Augmented Lipopolysaccharide-Induced TNF-{alpha} Production by Peritoneal Macrophages in Type 2 Diabetic Mice Is Dependent on Elevated Glucose and Requires p38 MAPK. Sherry, C.L., O'connor, J.C., Kramer, J.M., Freund, G.G. J. Immunol. (2007) [Pubmed]
  22. Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages. Dushkin, M.I., Khoshchenko, O.M., Kudinova, E.N., Schwartz, Y.S.h. Bull. Exp. Biol. Med. (2006) [Pubmed]
  23. The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy. Cheng, J.B., Watson, J.W., Pazoles, C.J., Eskra, J.D., Griffiths, R.J., Cohan, V.L., Turner, C.R., Showell, H.J., Pettipher, E.R. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  24. Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Stolz, D.B., Zamora, R., Vodovotz, Y., Loughran, P.A., Billiar, T.R., Kim, Y.M., Simmons, R.L., Watkins, S.C. Hepatology (2002) [Pubmed]
  25. In vivo efficacy of telithromycin on cytokine and nitric oxide formation in lipopolysaccharide-induced acute systemic inflammation in mice. Lotter, K., Höcherl, K., Bucher, M., Kees, F. J. Antimicrob. Chemother. (2006) [Pubmed]
  26. A novel dual regulator of tumor necrosis factor-alpha and interleukin-10 protects mice from endotoxin-induced shock. Fukuda, T., Sumichika, H., Murata, M., Hanano, T., Adachi, K., Hisadome, M. Eur. J. Pharmacol. (2000) [Pubmed]
  27. 17beta-estradiol- and lipopolysaccharide-induced changes in nitric oxide, tumor necrosis factor-alpha and vascular endothelial growth factor release from RAW 264.7 macrophages. Tomaszewska, A., Guevara, I., Wilczok, T., Dembińska-Kieć, A. Gynecol. Obstet. Invest. (2003) [Pubmed]
  28. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Rice, G.C., Brown, P.A., Nelson, R.J., Bianco, J.A., Singer, J.W., Bursten, S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  29. Tumor necrosis factor-alpha regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia. Harbrecht, B.G., Di Silvio, M., Demetris, A.J., Simmons, R.L., Billiar, T.R. Hepatology (1994) [Pubmed]
  30. Mapping of a minimal AU-rich sequence required for lipopolysaccharide-induced binding of a 55-kDa protein on tumor necrosis factor-alpha mRNA. Lewis, T., Gueydan, C., Huez, G., Toulmé, J.J., Kruys, V. J. Biol. Chem. (1998) [Pubmed]
  31. Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: potential role of simvastatin-mediated inhibition of Egr-1 expression and activation. Bea, F., Blessing, E., Shelley, M.I., Shultz, J.M., Rosenfeld, M.E. Atherosclerosis (2003) [Pubmed]
  32. A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B. Gravallese, E.M., Boothby, M.R., Smas, C.M., Glimcher, L.H. Mol. Cell. Biol. (1989) [Pubmed]
  33. ATP released by LPS increases nitric oxide production in raw 264.7 macrophage cell line via P2Z/P2X7 receptors. Sperlágh, B., Haskó, G., Németh, Z., Vizi, E.S. Neurochem. Int. (1998) [Pubmed]
  34. Gene silencing by systemic delivery of synthetic siRNAs in adult mice. Sørensen, D.R., Leirdal, M., Sioud, M. J. Mol. Biol. (2003) [Pubmed]
  35. IL-10 receptor dysfunction in macrophages during chronic inflammation. Avdiushko, R., Hongo, D., Lake-Bullock, H., Kaplan, A., Cohen, D. J. Leukoc. Biol. (2001) [Pubmed]
  36. Anti-inflammatory potency of FR167653, a p38 mitogen-activated protein kinase inhibitor, in mouse models of acute inflammation. Nishikori, T., Irie, K., Suganuma, T., Ozaki, M., Yoshioka, T. Eur. J. Pharmacol. (2002) [Pubmed]
  37. Increased mortality and inflammation in tumor necrosis factor-stimulated gene-14 transgenic mice after ischemia and reperfusion injury. Souza, D.G., Soares, A.C., Pinho, V., Torloni, H., Reis, L.F., Teixeira, M.M., Dias, A.A., Martins, M.T. Am. J. Pathol. (2002) [Pubmed]
  38. Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination. Chen, H., Wu, Y., Zhang, Y., Jin, L., Luo, L., Xue, B., Lu, C., Zhang, X., Yin, Z. FEBS Lett. (2006) [Pubmed]
  39. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. Shinohara, H., Inoue, A., Toyama-Sorimachi, N., Nagai, Y., Yasuda, T., Suzuki, H., Horai, R., Iwakura, Y., Yamamoto, T., Karasuyama, H., Miyake, K., Yamanashi, Y. J. Exp. Med. (2005) [Pubmed]
  40. Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT-1 and NF-kappa B) complexes by antibody-dependent enhancement of macrophage infection by Ross River virus. Mahalingam, S., Lidbury, B.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  41. The resistance of P. acnes--primed interferon gamma-deficient mice to low-dose lipopolysaccharide-induced acute liver injury. Shimizu, Y., Margenthaler, J.A., Landeros, K., Otomo, N., Doherty, G., Flye, M.W. Hepatology (2002) [Pubmed]
  42. CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses. Vinay, D.S., Choi, B.K., Bae, J.S., Kim, W.Y., Gebhardt, B.M., Kwon, B.S. J. Immunol. (2004) [Pubmed]
  43. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. Medvedev, A.E., Kopydlowski, K.M., Vogel, S.N. J. Immunol. (2000) [Pubmed]
  44. Tumor necrosis factor alpha regulates expression of the major histocompatibility complex class II-associated invariant chain by binding of an NF-kappa B-like factor to a promoter element. Pessara, U., Koch, N. Mol. Cell. Biol. (1990) [Pubmed]
  45. Cisplatin inactivation of caspases inhibits death ligand-induced cell death in vitro and fulminant liver damage in mice. Shin, J.N., Seo, Y.W., Kim, M., Park, S.Y., Lee, M.J., Lee, B.R., Oh, J.W., Seol, D.W., Kim, T.H. J. Biol. Chem. (2005) [Pubmed]
  46. Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia. Sawada, M., Suzumura, A., Hosoya, H., Marunouchi, T., Nagatsu, T. J. Neurochem. (1999) [Pubmed]
  47. Heat shock inhibition of lipopolysaccharide-mediated tumor necrosis factor expression is associated with nuclear induction of MKP-1 and inhibition of mitogen-activated protein kinase activation. Sanlorenzo, L., Zhao, B., Spight, D., Denenberg, A.G., Page, K., Wong, H.R., Shanley, T.P. Crit. Care Med. (2004) [Pubmed]
  48. Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia co-cultures. Liu, B., Du, L., Kong, L.Y., Hudson, P.M., Wilson, B.C., Chang, R.C., Abel, H.H., Hong, J.S. Neuroscience (2000) [Pubmed]
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